BOD 1

BOD 1

1. BOD

   • Endocrine disease
     • Infertility
       • Ovulatory dysfunction markers
       • Causes
         • Lifestyle
         • Infection
         • Ovulatory disorders
           • hyperprolactinemia
           • Androgen excess
             • CAH
           • Hormone imbalance
             • PCOS
           • Hypothalamic pituitary insufficiency
       • Maintenance of pregnancy
         • Common disorders
         • Common complications
   • Diabetes
     • Insulin
       • Effect on target tissues
     • IDDM
       • Pathophysiology
       • Clinical markers
     • NIDDM
       • Insulin signalling
         • Insulin receptor structure
         • TK-IRS-p110-pip2>pip3-PKB
           • PKB targets
             • GSK3
             • AS160
             • TSC1/2
             • FOXO
         • Signalling defects
           • IRS-1
           • aPKC
       • Pathophysiology
         • Effect of elevated glucose
           • AGE/RAGE system
             • Inflammation and mitochondria
         • Effect of elevated lipids
     • Complications
       • Nephropathy
       • Retinopathy
       • Neuropathy
       • Athesclerosis
     • Other types
       • MODY
         • 11 types and mutations
         • Treatment
       • PNDM
     • Treatment
       • Diet/exercise
       • Drug therapy
         • Sulphonylureas
         • Glitazones
           • PPARY
         • Metformin
           • AMPK
         • DPP4 inhibitors
   • Hirschsprung's disease
     • Origin of ENS
     • Genetic ENS dysfunction
       • Transcription factors
         • SOX10
       • Ligands and receptors
         • Endothelin-3 pathway
         • Neurotrophin/RET pathway
       • Other candidate genes
         • Phox-2b
         • Ncx
     • Cell bio of crest migration
       • Imaging methods
       • Conclusion from avian work
     • Stem cell implants and restrictions
     • ICCs and C-kit

2. Cytoskeleton

   • Desmin
     • Role in muscle
       • Mitochodria
         • Myotubules
         • Plectin Isoforms
       • Role in Sarcolemma and Costamere
         • Functional role
     • Desmin related myopathy
       • Histological observations
         • Calcification
         • Fibrotic lesions
         • Mitochondrial dissorganisation
           • Number
           • morphology
           • Function
             • ADP induced respiration
       • Mutations
         • Phenotype
           • Protein aggregates
             • Pathogenesis
               • processed by casp 6
               • N termial product inhibits IF
               • Apoptosis
             • Treatment
               • anti-apoptotic factors
               • inc chaperone
               • inc autophagy
                 • atg7
               • inc proteosome
                 • pa28-alpha
           • Apoptosis
             • Anti-apoptotic factors Bcl-2
   • Proteastasis/myofribrillogenesis
     • The proteasome
       • Ubiquitination
         • Cardiac Calpain-1
     • Autophagy
       • Macro
       • Micro
       • CMA
         • Sarcomere specialised chaperones
           • Myosin
             • Hsp90/UNC-45
           • Desmin
             • aB-Crystalin
         • Roles
           • Quality control
           • Maintainence
           • AA source
       • Regulation
         • Growth factor
           • Atg genes
         • Energy
           • AMPK
         • Nutrient
           • eIF2alpha
     • Process
       • 1.Synthesised 2. Correctly folded 3. Assembled stoichiometrically (Hsp90) 4. Interact in a spatiotemporal manner
       • Dynamic remodelling
         • Mechanical
         • Metabolic