DMARDs

DMARDs

1. Generic

   • Sulfasalazine
     • Nausea
     • Skin rashes
     • Mouth ulcers
   • Methotrexate
     • Nausea
     • Mouth Ulcers
     • Diarrhoea
     • Renal Impairment
     • Pulmonary Fibrosis
     • TERATOGENIC
   • ALL CAUSE
     • Abnormal liver biochemistry
     • Neutropenia/thromocytopenia
   • Leflunomide
     • Diarrhoea
     • Alopecia
     • Hypertension
     • TERATOGENIC

2. TNF Alpha Blockers

   • Examples
     • Etanercept
     • Adalimumab
     • Infliximab
     • "In and exit"
   • All can be used with methotrexate
   • Side Effects
     • Injection site reactions
     • Infections eg. TB, sepsi
     • Heart failure

3. Other Biologics

   • Used with methotrexate
   • Anakinra
     • Injection site reactions
   • Rituximab
     • Hypo/hypertension
     • Skin rash
     • Back pain
   • Abatacept
     • Nausea
     • Vomiting
     • Headache
   • Toclilizumab
     • Headache
     • Anaphylaxis
     • Fever