Regulation of Na+ & Cl- Balance

Regulation of Na+ & Cl- Balance

1. Regulation of filtered load of Na+ (via GFR)

   • Na+ reabsorption at DCT and CCD via the action of aldosterone (major control of Na+ excretion).
   • nearly all Na+ in filtrate is reabsorbed: 65% in PCT, 25% in asc LoH.

2. Regulation of Na+ reabsorption

3. Macula densa cells

   • lower concentrations in Na+
     • activate Mesangial cells
   • higher concentrations in Na+
     • adenosine release

4. Mesangial cells

   • secrete renin

5. Renin system in Hemorrhage

6. renin system

7. Short-term regulation of blood pressure

8. regulation of blood pressure

9. Pressure natriuresis and diuresis

10. Summary of regulation of blood pressure via the kidney

11. BP regulation in diarhhea

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