Enterobacteria

Enterobacteria

1. Salmonella

   • Cycle of transmission
   • Salmonellosis
     • Secretion system
       • Type 1 & 2
     • Effector proteins
       • SopE
         • Membrane ruffling
       • SipA
         • Aids process
       • SipB
         • Induce inflammation
       • SopA
         • Neutrophils-inflammation
       • Sif
         • Forms filaments
       • Ssef
         • Redirests golgi traffic

2. Shigella

   • Shigellosis
     • Virulance factors
       • IpaC
         • Cdc42 & Rac1
           • Actin polymerisation
       • IpaD
         • lossens focal adhesions
       • VirA
         • Rho GTPases
           • Destabilises microtubules
       • VirF
         • Induces gene expression at 37
       • Shigella protrusions
         • IcsA
           • Binds N-WASP
     • Secretion system
       • Type 3
       • LPS glucosylation

3. Helicobacter Pylori

   • Symptoms
     • Gastic ulcers
     • Duodenal ulcers
     • Inflammation
       • MALT lymphoma
       • gastric carcinoma
   • Virulence factors
     • Flagella
     • Urease
       • Diagnosis
         • 13C urea test
         • pH sensitive biopsy
     • Adhesins
     • Secretion systems
       • Type 4
     • CagA toxins
       • SHP2 activated
         • Erk Map Kinase
         • Hummingbird phenotype
           • Increased motility
     • Vacuolating toxins
       • Hexameric pore
         • Apoptosis
       • P37
       • P58
     • LPS immune mimcry