Test
PHSI3012 09-1 Atherothrombosis
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Preguntas del test (19)
1What’s the most common type of heart disease, and leading cause of death?
- ACoronary Artery Disease
- BStroke
- CDeath
- DPeripheral Artery Disease
- ECentral Artery Disease
2There are two major categories of stroke. 80% are which one?
- AIschaemic
- BHaemorrhagic
3Platelets are disc-shaped fragments produced by __________.
- AMegakaryotes
- BMegakaryocytes
- CMinikaryocytes
- DMinikaryotes
- ESpleen
- FBlasts
4Average platelet count is:
- A150,000 – 400,000 / μL
- B150 – 400 / μL
- C1,500 – 4,000 / μL
- D15,000 – 40,000 / μL
- E150,000 – 40,000 / μL
5Which of the following are functional responses of platelets?
- APrimary adhesion
- BShape change
- CAggregation
- DGranule release
- EProcoagulant function
- FAnticoagulant function
- GSecondary adhesion
- HAntiapoptotic function
- IProapoptotic function
- JCarry Oxygen
6Shape change is a crucial functional response of platelets to …something. They change shape from [blank_start]__________[blank_end] to [blank_start]__________[blank_end]
- AFlat disc
- BSpiny disc
- CSpiny sphere
- DSmooth sphere
7Which receptor/ligand interactions occur during which bit?
- AGPIb/V/IX – vWF
- BαIibβ3 – fibronectin, VWF
- CαIibβ3 – fibrinogen, fibronectin
- DGPIb/V/IX – vWF
- EαIibβ3 – fibronectin, VWF
- FαIibβ3 – fibrinogen, fibronectin
- GGPIb/V/IX – vWF
- HαIibβ3 – fibronectin, VWF
- IαIibβ3 – fibrinogen, fibronectin
8Fibrin generation at the site of vascular injury has a crucial role in anchoring the thrombus to the vessel. It requires initiation of coagulation and generation of thrombin. This depends on Tissue Factor (TF) expression on the surface of [blank_start]__________[blank_end] and fibroblasts.
- ASmooth Muscle Cells (SMCs)
- BVascular Endothelial Cells (VECs)
- CVascular Epithelial Cells (VECs)
- DSkeletal Muscle Cells (SMCs)
- ECardiac Muscle Cells (CMCs)
9Platelet-mediated fibrin clot retraction shrinks the size of the blood clot. Thought to be important for stabilising the clot against shear forces of blood flow. This requires:
- AIntegrin αIIbβ3
- BFibrin
- CMyosin/contractile force
- DActin cytoskeleton
10Which of the following are prothrombotic and which are antithrombotic?
ADP: [blank_start]__________[blank_end];
Aspirin: [blank_start]__________[blank_end];
Epinephrine: [blank_start]__________[blank_end];
Clopidogrel: [blank_start]__________[blank_end];
Collagen: [blank_start]__________[blank_end];
Heparin: [blank_start]__________[blank_end];
Thrombin: [blank_start]__________[blank_end];- APro
- BAnti
- CAnti
- DPro
- EPro
- FAnti
- GAnti
- HPro
- IPro
- JAnti
- KAnti
- LPro
- MPro
- NAnti
11Does Aspirin prevent initial platelet adhesion?
- ANope
- BYeah
12Does Aspirin prolong skin bleeding time?
- AYep
- BNope
13What’s the efficacy of Aspirin?
- A~5-10%
- B~15%
- C~25%
- D~30-50%
- E~50-70%
- F~75%
- G~85%
- H~90-95%
14Does Aspirin inhibit prostacyclin synthesis?
- AYep
- BNope
15Does Aspirin stimulate prostacyclin synthesis?
- ANope
- BYep
16Does Aspirin suppress the release of thrombogenic factors from platelets?
- ANope
- BYep
17Integrin αIibβ3 (GPIIbIIIa) inhibitors are:
- AAntithrombotic (but can cause severe bleeding)
- BProthrombotic (but can cause severe bleeding)
- CAntithrombotic (but can't cause severe bleeding)
- DProthrombotic (but can't cause severe bleeding)
18Which of the following are CURRENT (not further potential) antithrombotic treatments:
- AInhibitors of platelet activation
- BInhibitors of platelet adhesion
- CPAR antagonists
- DHomeopathy
19PAR antagonists are under development as a potential novel antithrombotic. What’s PAR?
- AProtease-Activated Receptor
- BProtease-Antigen Receptor
- CProtease-Antagonist Receptor
- DProtease-Agonist Receptor
- EProtease-Activating Receptor
Información
- Descripción
- PHSI3012 09-1 Atherothrombosis (T2L7) Outline: - Atherothrombosis and its clinical manifestations - Platelet biology and blood clot development - Antithrombotic strategies to combat atherothrombosis
- Autor
- Usuario eliminado
- Idioma
- English
- Visitas
- 38
- Historial
- Creado el 22 nov 2017 · actualizado el 23 nov 2017
- Etiquetas
- Valoración
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