Acquired Immunity: Cell-med and Humoral

Acquired Immunity: Cell-med and Humoral

1. Antigen Presenting Cell arrives at Lymphnode

   • APC
     • MHC II
     • Antigen
       • TCR
         • immature CD4+ T helper cells
           • Differentiation Maturation
             • Mature CD4+ THI cells
               • Bring over CD8+ T cells
                 • mature CD8+ T cells
                   • mature CD8+ T cells
                     • TCR
               • IL 2
                 • INF-gamma
               • further macrophage activation
               • production of IL-1
                 • helps with epithelial rolling
               • releases reactive oxygen species
     • IL 2
     • INF-gamma
     • MHC I
       • A
         • mature CD8+ T cells
           • Infected Cell
             • MHC I
               • A
                 • Release of Cytotoxic Granule
                   • Granzyme
                     • Perforin
                       • Punches Holes in cell's exterior
                     • Enzyme that messes up cell's interior
           • mature CD8+ T cells
             • Activation of "Death Sign
               • FAS-FAS Ligand
                 • Apoptosis
   • Cell Mediated Response
   • Humoral Response
     • APC
       • MHC II
         • A
           • TCR
             • immature CD4+ T helper cells
               • Differentiation Maturation
                 • Mature CD4+ TH II Cells
                   • IL 5
                     • B cell maturation
                       • Plasma B cells
                         • Undergoes Class Switch
                           •  Early stages of infection
                             • mainly IgM
                               • Innate antibody
                               • Very nonspecific
                                 • Pentamer
                               • BCR
                                 • IgD
                                 • IgM
                                 • Can accept antigen and trigger release of chemokine same way APC will
                                   • EARLY STAGES: IgM
                                     • IgM will act as a BCR and trigger
                                     • OR
                                       • cause class switch
                                         • b/c chemokine cause clonal selection and clonal expansion
                                     • APC will trigger
                             • Later stages of infection
                               • mainly IgG
                                 • specific antibody
                                 • Transplacental
                                 • Clumps and neutralizes pathogens
                         • produces the antibodies
                       • Memory B cells
                         • stores antibodies in case of second exposure
                       • Memory T cells
                   • IL 10
                     • inhibits maturation and proliferation after a while
                   • IL 4
                     • Clonal Selection
                     • Clonal Expansion
     • cannot happen without cell mediated