Anemia caused by ↑ RBC destruction or loss

Anemia caused by ↑ RBC destruction or loss

1. Intrinsic Abn

   • Membrane Defect
     • hereditary spheocytosis
     • hereditary elliptocytosis
       • pyropoikilocytosis (subset of HE)
     • paroxysmal nocturnal hemoglobinuria
     • hereditary stomatocytosis
     • hereditary xerocytosis
   • Enzyme Deficiency
     • G6PD
     • pyruvate kinase
   • Qualitative Globin Abn
     • Single Amino Acid Substitutions Usually in Beta Chain
       • Sickle cell anemia/trait
         • Hgb S: anemia; Hgb SA: trait
       • Hgb C Dx
         • Hgb AC
         • Hgb SC
       • Variant Hgbs
         • Hgb S-beta thal
         • Hgb E
         • Hgb D
         • Hgb Lepore (delta - beta fusion)

2. Extrinsic Abn

   • Immune Causes (Ab mediated)
     • Warm autoimmune hem anemia
     • Cold agglutinin Dx
     • Paroxysmal Cold Hemoglobinuria
     • HTR & HDFN
     • Immune Thrombocytopenia
   • Non Immune (not Ab mediated) RBC Injury
     • Microangiopathic hemolytic anemia
       • Thrombotic thrombocytic anemia
       • HELLP syndrome
       • DIC
       • HUS
     • Macroangiopathic hemolytic anemia
       • traumatic cardiac hemolysis
     • Infectious agents
       • malaria
       • babesiosis
       • bartonellosis
       • clostridial sepsis
     • Other injury
       • chemicals
       • drugs
       • burns
       • venoms
     • Non Megaloblastic Macrocytic Anemia
       • RBC destruction from underlying condition: BM compensates
         • hypothyroidism
         • chronic liver dx
         • alcoholism
         • chemo
         • post splenectomy
   • Acute Blood Loss

3. ↑ Retic