Exam 2: Meglitinides

Exam 2: Meglitinides

1. Pharmacokinetics

   • Rapid absorption & elimination
   • Metabolized in the liver
   • Biliary excretion

2. Pharmacological action

   • Increase pancreatic insulin production during and after meals

3. Adverse effects

   • Hypoglycemia

4. Contraindications

   • Renal Impairment
   • Hepatic impairment

5. Drug Interactions

   • Gemfibrozil (Lopid) inhibits metabolism, causing hypoglycemia

6. Nursing Interventions

   • LFTs/Cr at baseline
   • 2-hr post-prandial glucose

7. Extra information

   • No more than 4 doses per day
   • Repaglinide
   • Take no more than 30 min before a meal.
   • Skipping a dose = Skipping a meal Add a dose if adding a meal