Th2L02 DNA replication

Th2L02 DNA replication

1. Part of the cell cycle

2. G1 phase

   • Synthesis of protein components necessary to complete the cell cycle including histones, enzymes for replication, etc.
   • Takes 6-9 hours

3. S phase:

   • DNA synthesis commences
     • Overview
       • (1) DNA unwinds
       • (2) Daughter strands of DNA produced from parent strand at replication for
       • Semi conservation replication (each new DNA molecule contains one parent and one daughter strand)
         • Overall structure of the replication fork
           • Replication occurs 3' to 5' along parent strand
             • Leading strand
               • The new continuous complementary DNA strand synthesised along the template strand in the mandatory 5' to 3' direction.
             • Lagging strand
               • A discontinuously synthesised DNA strand that elongates by means of Okazaki fragment
                 • Okazaki fragments
                   • Small fragments of DNA produced on the lagging strand during DNA replication
                   • Joined later by DNA ligase to form a complete strand
               • Each synthesised in a 5' to 3' direction away from the replication fork.
           • New daughter strand is formed 5' to 3'
           • One leading strand and one lagging strand
       • Several enzymes are involved including helicase, DNA polymerase, primase, DNA ligase, etc.
   • Takes 8-9 hours

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