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Routes of Administration

Crystal Yu 17 preguntas Actualizado el 22 mar 2018

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Preguntas del test (17)

  1. 1Limiting factors that restrict drugs to certain dosage forms:
    • [blank_start]Solubility[blank_end]
    • [blank_start]Stability[blank_end]
    • [blank_start]Absorption[blank_end]
    • [blank_start]First pass[blank_end] effect
    • [blank_start]Dose[blank_end]
    1. ASolubility
    2. BStability
    3. CAbsorption
    4. DFirst pass
    5. EDose
  2. 2[blank_start]Sublingual[blank_end], [blank_start]buccal[blank_end], and [blank_start]IV[blank_end] dosage forms have a quick effect and reach maximum plasma concentration a lot faster after administration.
    1. ASublingual
    2. Bbuccal
    3. CIV
  3. 3[blank_start]Oral[blank_end] and [blank_start]ointment[blank_end] dosage forms reach its maximum plasma concentration a long time after administration.
    1. AOral
    2. Bointment
  4. 4Sublingual route dosage forms:
    - Tablets
    - [blank_start]Troches[blank_end]
    - [blank_start]Lozenges[blank_end]
    1. ATroches
    2. BLozenges
  5. 5Disadvantages of the oral route:
    - [blank_start]First pass[blank_end] effect
    - Unpredictable absorption due to factors such as [blank_start]diet[blank_end] and [blank_start]age[blank_end] that affect bioavailability
    1. AFirst pass
    2. Bdiet
    3. Cage
  6. 6If a drug is administered in a soluble form or it dissolves rapidly, [blank_start]membrane transport[blank_end] will become rate limiting step
    1. Amembrane transport
  7. 7Dissolution rate from highest to lowest are as following:
    [blank_start]Liquids[blank_end] and [blank_start]solutions[blank_end] > [blank_start]Suspensions[blank_end] > [blank_start]Capsules[blank_end] > [blank_start]Tablets[blank_end]
    1. ALiquids
    2. Bsolutions
    3. CSuspensions
    4. DCapsules
    5. ETablets
  8. 8[blank_start]Intrinsic dissolution[blank_end]: Dissolution rate that is specific to each drug
    - This is characterized by Noyes-Whitney equation
    1. AIntrinsic dissolution
  9. 9Factors affecting intrinsic dissolution:
    Increase in [blank_start]temperature[blank_end] = Increase in rate of dissolution (affects Cs)
    Decrease in [blank_start]viscosity[blank_end] = Increase in rate of dissolution (affects D)
    [blank_start]Agitation[blank_end] (mixing/taking with food) = Increase in rate of dissolution (affects h)
    Change in [blank_start]pH[blank_end] = Affects Cs
    Decrease in [blank_start]size[blank_end] = Increase in rate of dissolution (affects S)
    1. Atemperature
    2. Bviscosity
    3. CAgitation
    4. DpH
    5. Esize
  10. 10Factors affecting solubility:
    - [blank_start]Polymorphism[blank_end] (diamonds vs graphite)
    - [blank_start]Hydrated[blank_end] vs [blank_start]anhydrous[blank_end] form (thirsty)
    - [blank_start]Salt[blank_end] form (depends on drug)
    1. APolymorphism
    2. BHydrated
    3. Canhydrous
    4. DSalt

Información

Descripción
- Why do we need different routes of administration? - What are the most common route of administration? - What are the biopharmaceutical characteristics in terms of Absorption, Distribution, Metabolism and Elimination (ADME) dictating the fate of drugs from each routes of administration
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English
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52
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Creado el 21 mar 2018 · actualizado el 22 mar 2018
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