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DF03 Importance of solid state nature of drug powders

Mer Scott 10 preguntas

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Preguntas del test (10)

  1. 1Amorphous solids have short range order but not long range order.
    1. AVerdadero
    2. BFalso
  2. 2In a crystalline solid [blank_start]unit cells[blank_end] add together to make a [blank_start]crystal lattice[blank_end]. Atoms [blank_start]vibrate[blank_end] in place in a [blank_start]fixed[blank_end] pattern.
    1. Aunit cells
    2. Bcrystal lattice
    3. Cfixed
    4. Dvibrate
  3. 3Choose the incorrect statement
    1. AA crystal habit results from the way the unit cells are put together.
    2. BThe same unit cell might form plates or needles etc depending on crystallisation conditions.
    3. CMistakes in the crystal lattice – points of low energy – can be described as dislocations.
  4. 4The glass transition in [blank_start]amorphous[blank_end] materials (or in amorphous [blank_start]regions[blank_end] within [blank_start]semicrystalline[blank_end] materials) is from a relatively brittle "[blank_start]glassy[blank_end]" state into a viscous or [blank_start]rubbery[blank_end] state as the temperature is [blank_start]increased[blank_end]. With [blank_start]increasing[blank_end] molecular mobility, the glassy state would undergo the [blank_start]glass transition[blank_end] at a particular temperature, [blank_start]Tg[blank_end], into the rubbery state.
    The glass-transition temperature is always [blank_start]lower[blank_end] than the melting temperature, [blank_start]Tm[blank_end], of the crystalline state of the material, if one exists.
    1. Aamorphous
    2. Bregions
    3. Csemicrystalline
    4. Dglassy
    5. Erubbery
    6. Fincreased
    7. Gdecreased
    8. Hincreasing
    9. Idecreasing
    10. Jglass transition
    11. KTg
    12. Llower
    13. Mhigher
    14. NTm
  5. 5Amorphous solids are more stable in the presence of moisture.
    1. AVerdadero
    2. BFalso
  6. 6Crystalline solids:
    - [blank_start]Definite[blank_end] shape and geometrical form
    - [blank_start]Sharp[blank_end] melting point
    - [blank_start]Clean[blank_end] cleavage, i.e., break into pieces with plane surfaces
    - [blank_start]Anisotrophic[blank_end] (mechanical properties and electrical properties depend on the direction along which they are measured)

    Amorphous solids:
    - [blank_start]No definite[blank_end] geometrical shape
    - Melt over [blank_start]wide range[blank_end] of temperatures
    - [blank_start]Irregular[blank_end] cleavage
    - [blank_start]Isotrophic[blank_end] (similar physical properties in all directions because the constituents are arranged in random manner)
    1. ADefinite
    2. BNo definite
    3. CSharp
    4. Dwide range
    5. EClean
    6. FIrregular
    7. GAnisotrophic
    8. HIsotrophic
  7. 7Choose the correct statement.
    1. AAmorphous solids are more stable than crystalline solids.
    2. BAmorphous solids are less soluble than crystalline solids.
    3. CAmorphous solids dissolute faster than crystalline solids.
  8. 8Absorption and activity of amorphous solids will be faster than stable crystalline form solids.
    1. AVerdadero
    2. BFalso
  9. 9Which of these is not a way to formulate amorphous solids?
    1. ARapid freezing of a melt (quench cooling)
    2. BRapid precipitation by solvent quenching or pH change
    3. CFreeze drying (lyophilization)
    4. DMilling
    5. ESpray drying
    6. FExtrusion
    7. GHeat drying
  10. 10An amorphous drug must be formulated to [blank_start]reduce[blank_end] risk ofcrystallisation. The solid state transformation may be slowed down or prevented by adding [blank_start]protective colloids[blank_end]. Drug may be dissolved, eg [blank_start]solid solution[blank_end], or dispersed in a polymer, eg [blank_start]solid suspension[blank_end]. often a polymer with [blank_start]high[blank_end] Tg is added to the drug to form a solid dispersion eg [blank_start]PVP[blank_end] (polyvinylpyrrolidone) or [blank_start]HPMC[blank_end] (hydroxypropyl methylcellulose).
    To summarise, to store an amorphous drug safely we will need a polymer to [blank_start]increase[blank_end] Tg so the amorphous drug remains in a [blank_start]glassy[blank_end] state, and which has [blank_start]interactions[blank_end] with the amorphous drug--if the amorphous interacts with the polymer it is [blank_start]less[blank_end] likely to form nuclei & crystallise. We also need to protect it from moisture & high temperature.
    1. Areduce
    2. Bprotective colloids
    3. Csolid solution
    4. Dsolid suspension
    5. Ehigh
    6. FPVP
    7. GHPMC
    8. Hincrease
    9. Iglassy
    10. Jinteractions
    11. Kless

Información

Descripción
(Formulation) PHCY211 Test sobre DF03 Importance of solid state nature of drug powders, creado por Mer Scott el 28/04/2018.
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