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DF09 Solutions influencing precipitation

Mer Scott 6 preguntas Actualizado el 29 abr 2018

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Preguntas del test (6)

  1. 1Which of these is not a chemical modification strategy for improving solubility of weak electrolytes?
    1. ACo-solvency
    2. BpH adjustment
    3. CSolid state/crystalline form change
    4. DComplexation
    5. ESalt formation
  2. 2Salt formation can [blank_start]drastically[blank_end] improve the solubility of a drug. Common salts used for basic drugs are [blank_start]hydrochloride and methanesulfate[blank_end], while common salts used for acidic drugs are [blank_start]sodium, calcium, potassium[blank_end], etc.
    1. Adrastically
    2. Bhydrochloride and methanesulfate
    3. Csodium, calcium, potassium
  3. 3For determining pH of weak acids in solution we use the equation [blank_start]pH = 1/2pKa − 1/2 log C[blank_end].
    For determining pH of weak bases in solution we use the equation [blank_start]pH = 1/2 pKw + 1/2 pKa + 1/2 log C[blank_end]. Remember, pKw = 14.
    1. ApH = 1/2pKa − 1/2 log C
    2. BpH = 1/2 pKw + 1/2 pKa + 1/2 log C
  4. 4For determining solubility of a weak acid we use [blank_start]pHp = pKa + log (S-So/So)[blank_end], where S is the total solubility and So is the solubility of the unionised form.
    For determining solubility of a weak base we use [blank_start]pHp = pKa + log (S/S-So)[blank_end].
    To convert S (mol/L) into mg/mL we use [blank_start]n=m/M[blank_end].
    1. ApHp = pKa + log (S-So/So)
    2. BpHp = pKa + log (S/S-So)
    3. Cn=m/M
  5. 5Co-solvency is the phenomenon where a solute is [blank_start]more[blank_end] soluble in a [blank_start]mixture[blank_end] of solvents (partially or completely miscible) than in one solvent alone. Common pharmaceutical co-solvents (which are semi-polar) are ethanol, [blank_start]propylene[blank_end] glycol, and [blank_start]glycerol[blank_end].
    1. Amore
    2. Bmixture
    3. Cglycerol
    4. Dpropylene
  6. 6Choose the incorrect statement.
    1. ACo-solvents increase solubility of ionised species (by adjusting the solvent polarity)
    2. BCo-solvents influence pKa ∴ pH adjustment is required in formulation
    3. CPropylene glycol, used in anti-freeze and as a co-solvent, is toxic to humans.

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Descripción
(Formulation) PHCY211 Test sobre DF09 Solutions influencing precipitation, creado por Mer Scott el 29/04/2018.
Idioma
English
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3
Historial
Creado el 29 abr 2018 · actualizado el 29 abr 2018
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