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DF17 Complexation

Mer Scott 6 preguntas

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Preguntas del test (6)

  1. 1API complexation with other components in a formulation can be intentional or desirable.
    1. AVerdadero
    2. BFalso
  2. 2There are four main types of complexation:
    1. Ion-pair formation
    • [blank_start]Cation-anion interaction[blank_end]
    2. Metal ion (coordination) complexes
    • e.g. [blank_start]chelates[blank_end] (EDTA-metal ions, tetracycline-divalent cations)
    3. [blank_start]Organic molecular[blank_end] complexes
    • e.g. drug-drug, drug-excipient, excipient-excipient complexes; ion exchange
    4. [blank_start]Inclusion[blank_end] complexes
    • Cyclodextrin-drug complexes
    1. ACation-anion interaction
    2. Bchelates
    3. COrganic molecular
    4. DInclusion
  3. 3Ion-pair formation is when a large organic anion interacts with a large organic cation to form a relatively [blank_start]insoluble complex[blank_end]. This is bad for particles in an [blank_start]IV infusion[blank_end] but good for [blank_start]sustained release[blank_end] injections.
    1. Ainsoluble complex
    2. BIV infusion
    3. Csustained release
  4. 4Choose the incorrect statement about metal ion complexes.
    1. AEDTA is a therapeutic chelator used for lead/mercury poisoning.
    2. BEDTA is a hexadentate ligand.
    3. CChelation occurs with divalent cations
    4. DThe drug eg tetracycline is the electron acceptor and the metal cation is the electron donor.
  5. 5Organic molecular complexes often involve complexation of [blank_start]esters[blank_end] (eg benzocaine) & [blank_start]amines[blank_end] (caffeine).
    Formation of molecular complexes can affect drug [blank_start]absorption[blank_end].
    1. Aesters
    2. Bethers
    3. Camines
    4. Damides
    5. Eabsorption
    6. Fdissolution
  6. 6Inclusion complexes involve cyclodextrin, a molecule with a [blank_start]hydrophobic cavity[blank_end] that can form a complex with a [blank_start]hydrophobic drug[blank_end]. Cyclodextrin complexes [blank_start]increase[blank_end] aqueous solubility; often [blank_start]linearly[blank_end], increase aqueous [blank_start]stability[blank_end], and increase drug bioavailability.
    1. Ahydrophobic cavity
    2. Bhydrophobic drug
    3. Cincrease
    4. Dlinearly
    5. Estability
    6. Fdecrease
    7. Ginstability

Información

Descripción
(Formulation) PHCY211 Test sobre DF17 Complexation, creado por Mer Scott el 30/04/2018.
Idioma
English
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