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Test

L9 Absorption

Mer Scott 12 preguntas

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Preguntas del test (12)

  1. 1Drug absorption is the ability of a drug to pass through a biological [blank_start]membrane[blank_end]. Absorption is defined with the [blank_start]absorption rate[blank_end] constant, Ka, and the Tmax, time at which concentration of the drug is [blank_start]maximum[blank_end]. The determinants of drug absorption from the gut are:
    1. [blank_start]Disintegration[blank_end] of the dosage form and [blank_start]dissolution[blank_end] of the drug
    2. Physiology of [blank_start]gastrointestinal tract[blank_end]
    3. Food or drug [blank_start]interactions[blank_end] in the gut lumen
    4. Passage through the gut [blank_start]wall[blank_end]
    1. Amembrane
    2. Babsorption rate
    3. Cmaximum
    4. DDisintegration
    5. Edissolution
    6. Fgastrointestinal tract
    7. Ginteractions
    8. Hwall
  2. 2Disintegration of the dosage form depends on the release characteristics of [blank_start]dosage form[blank_end], and the physicochemical [blank_start]properties[blank_end] of the drug(charge, particle [blank_start]size[blank_end], etc).
    Concerning the gut physiology, absorption rate is affected by gastric [blank_start]emptying[blank_end]. This is highly [blank_start]variable[blank_end] between people. When fasting, it typically takes an [blank_start]hour[blank_end] for solid forms and [blank_start]10-20 minutes[blank_end] for drugs in solution. After eating it is much [blank_start]slower[blank_end] (> 7 h in some cases). Gastric emptying time may impact absorption rate for drugs that readily dissolve in the stomach (paracetamol) or enteric coated drugs
    Insoluble drugs may have [blank_start]enhanced[blank_end] absorption if transit time is slow
    1. Adosage form
    2. Bproperties
    3. Csize
    4. Demptying
    5. Evariable
    6. Fhour
    7. G10-20 minutes
    8. Hslower
    9. Ienhanced
  3. 3Altered motility of the gut will usually impact the extent, not rate of absorption.
    1. AVerdadero
    2. BFalso
  4. 4Food or drug interactions in the gut lumen may affect absorption rate.
    They can do this by [blank_start]altering[blank_end] pH, and therefore [blank_start]solubility[blank_end]. E.g. acid suppressants ([blank_start]PPIs[blank_end]) & dabigatran in the wrong pH can decrease absorption by about 30%. [blank_start]Complexation[blank_end] can also alter absorption. E.g. Di- and tri- valent ions in [blank_start]antacids[blank_end] can affect alendronate and quinolone antibiotics.
    1. Aaltering
    2. Bsolubility
    3. CPPIs
    4. DComplexation
    5. Eantacids
  5. 5Passive diffusion is the primary absorption process for most drugs.
    1. AVerdadero
    2. BFalso
  6. 6Rate of flux (diffusion) will depend on:
    1. Athe concentration gradient and the drug permeability
    2. Bthe concentration gradient and drug ionisation state
    3. Cthe drug permeability and drug ionisation state
    4. Dthe membrane permeability and the concentration gradient
  7. 7Drug permeability is determined by:
    (Select all that apply)
    1. AMolecular size
    2. BIonisation state
    3. CLipophilicity
    4. DConcentration gradient
    5. EDosage form
  8. 8Small polar drugs, e.g. alcohol can be absorbed by [blank_start]paracellular[blank_end] diffusion.
    Many endogenous compounds (e.g. glucose) are absorbed by [blank_start]facilitated[blank_end] transport. No input of energy is required as movement is [blank_start]down[blank_end] a concentration gradient. The transporters involved are highly [blank_start]selective[blank_end].
    Active transport is where energy is required. Transporters are [blank_start]saturable[blank_end] and can be competitively inhibited (consider drug [blank_start]interactions[blank_end]). These include [blank_start]efflux[blank_end] transporters (e.g. P-glycoprotein) that [blank_start]limit[blank_end] drug absorption from the gut.

    1. Aparacellular
    2. Bfacilitated
    3. Cdown
    4. Dselective
    5. Esaturable
    6. Finteractions
    7. Gefflux
    8. Hlimit
  9. 9An absorption rate constant of 0.5 which has units of h-1 suggests that approximately 50% of the remaining drug in the gut will be absorbed every hour, but this is a gross approximation.
    1. AVerdadero
    2. BFalso
  10. 10Oral absorption often approximates first order PK behaviour.
    1. AVerdadero
    2. BFalso

Información

Descripción
PHCY310 Test sobre L9 Absorption, creado por Mer Scott el 07/04/2019.
Idioma
English
Visitas
10
Etiquetas
phcy310
Valoración
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