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Local Anesthetics - quiz

thomasina413 13 preguntas

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Preguntas del test (13)

  1. 1A weak acid becomes more than 50% un-ionized following IV injection (blood pH = 7.4). The pKa of this weak acid could be...
    1. A7.6
    2. B7.4
    3. C7.2
    4. D1.5
  2. 2When injected into the body, any of the local anesthetics used currently in clinical practice will be:
    1. Aless than 50% un-ionized
    2. Bmore than 50% un-ionized
    3. C50% un-ionized
    4. D100% un-ionized
  3. 3Sodium drug has pKa of 8.2. When injected into the blood, this drug will become:
    1. Aless than 50% un-ionized
    2. Bmore than 50% un-ionized
    3. C50% un-ionized
    4. D100% un-ionized
  4. 4What situation most facilitates accumulation of local anesthetic by the fetus?
    1. Amaternal acidosis and fetal acidosis
    2. Bmaternal acidosis and fetal alkalosis
    3. Cmaternal alkalosis and fetal alkalosis
    4. Dmaternal alkalosis and fetal acidosis
  5. 5Potency is determined by what property(ies) of a local anesthetic?
    1. ApKa
    2. Blipid solubility
    3. Cprotein binding
    4. Dboth lipid solubility and protein binding
  6. 6Speed of onset is determined by what property(ies) of a local anesthetic?
    1. ApKa
    2. Blipid solubility
    3. Cprotein binding
    4. Dboth lipid solubility and protein binding
  7. 7Duration of action is determined by what property(ies) of a local anesthetic?
    1. ApKa
    2. Blipid solubility
    3. Cprotein binding
    4. Dboth lipid solubility and protein binding
  8. 8Local anesthetics work on which segment(s) of the neuron?
    1. Aaxon only
    2. Bcell body and axon
    3. Caxon and nerve terminal
    4. Dcell body, axon and nerve terminal
  9. 9Conduction block occurs when the...
    1. Aionized form of the local anesthetic binds to the voltage-gated sodium channel outside the cell
    2. Bionized form of the local anesthetic binds to the voltage-gated sodium channel inside the cell
    3. Cun-ionized form of the local anesthetic binds to the voltage-gated sodium channel outside the cell
    4. Dun-ionized form of the local anesthetic binds to the voltage-gated sodium channel inside the cell
  10. 10You can make your own local anesthetic. If you want the local anesthetic to have a fast onset, you will want to have the local anesthetic have what pKa?
    1. A2.3
    2. B7.0
    3. C7.4
    4. D11.5

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Pharmacology - Bio 528
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