Test
Anti-Diabetic Drugs Quiz
Este test tiene tipos de pregunta que se abren en el reproductor de siempre.
Preguntas del test (85)
1Which of the following drugs are the only medications approved for the use in the treatment of Type 1 DM?
- APramlintide (Symlin)
- BMiglitol (Gylset)
- CInsulin
- DPioglitazone (Actos)
2Increntin hormones like GLP-1 and GIP stimulate insulin secretion in response to meals
- AVerdadero
- BFalso
3Specify how each of the following specified areas contribute to the pathophysiology of Type 2 DM
- Adecreased glucose uptake
- Bdecreased incretin effect
- Cincreased lipolysis
- Ddecreased insulin secretion (beta cells)
- Edecreased glucose uptake
- Fincreased production of glucose
- Gneurotransmitter dysfunction
- Hincreased glucagon secretion
- Iincreased lipolysis
- Jdecreased glucose uptake
- Kincrease production of glucose
- Lincrease glucose reabsorption
- Mneurotransmitter dysfunction
- Nincreased glucose reabsorption
- Odecreased incretin effect
- Pincrease glucagon secretion
- Qneurotransmitter dysfunction
- Rincreased lipolysis
- Sdecrease glucose uptake
- Tincreased production of glucose
- Uincreased glucagon secretion (alpha cell
- Vdecreased glucose uptake
- Wincreased glucose reabsorption
- Xincreased lipolysis
- Ydecreased glucose uptake
- Zincreased production of glucose
- AAdecreased incretin effect
- ABincreased glucagon secretion (alpha)
- ACdecreased insulin secretion (beta cells)
- ADincreased glucagon secretion (alpha cell
- AEdecreased incretin effect
- AFincreased lipolysis
4Pramlintide (Symlin) belongs to what drug class?
- Aalpha-glucosidase inhibitors
- Bamylinomimetics
- CMegltinides
- DSulfonylureas
5What type of efficacy does the following anti-diabetic drugs have?
Metformin, Sulfonyureas, TZDs, GLP-1- ALow efficacy (< 0.5 decrease in A1C)
- BIntermediate efficacy (~0.5-1 % decrease in A1C)
- CHigh efficacy ( ~1-2% decrease in A1C)
6What type of efficacy do the following drugs have?
SGLT2, DPP-IV, Alpha-glucosidase inhibitors- AHigh efficacy (~1-2% decrease in A1C)
- BIntermediate efficacy (~0.5-1% decrease in A1C)
- CLow efficacy (< 0.5% decrease in A1C)
7Of the following anti-diabetic drugs, which have the lowest efficacy in regards to the lowering of the A1C?
- AColesvelam
- BMetformin
- CInsulins
- DBromocriptine
8[blank_start]Pramlintide (Symlin)[blank_end] has a BBW for severe HYPOglycemia
- APramlintide
9Which of the following are contraindications for Pramlintide (Symlin)?
- Agastroparesis
- BHYPOglycemic unawareness
- Cpoor compliance with drug insulin regimens
- Dpediatric patients
- Einflammatory bowel disease
- Fcolonic ulceration
10If taking anti-diabetic drug [blank_start]Pramlintide (Symlin)[blank_end], the meal time insulin must reduced by 50%.
- APramlintide
11Pramlintide (Symlin) must be injected immediately prior to each major meal.
- AVerdadero
- BFalso
12Miglitol (Glyset) and Acarbose (Precose) belong to what anti-diabetic drug class?
- AAmylinomimetics
- Balpha-glucosidase inhibitors
- CBiguanides
- DTZD's
13What is the MOA for the alpha-glucosidase inhibitors?
- Aactivation of amylin
- Bactivates the nuclear transcription factor PPAR-gamma
- Cinhibits intestinal alpha glucosidase
- Dactivates GLP-1 receptors
14The [blank_start]alpha-glucosidase[blank_end] drug class slows intestinal carbohydrate digestion/absorption.
- Aalpha-glucosidase
- Bsecretagogues
- CTZDs
- DBiguanides
15Alpha-glucosidase drugs must be taken with the 1st bite of each meal
- AVerdadero
- BFalso
16Which of the following are adverse drug reactions for alpha-glucosidase class?
- AGI disturbances
- Bflatulence
- Cheadache
- Delevation in hepatic enzymes
17Contrainidcations for the [blank_start]alpha-glucosidase inhibitors[blank_end] include inflammatory bowel disease, colonic ulceration, intestinal obstruction, malabsorption, and CrCL < 25 mL/min
- Aalpha-glucosidase inhibitors
- Bamylinomimetics
- CDPP-IV
- DMeglitinides
18Hypoglycemia must be treated with what when taking an alpha glucosidase inhibitor.
- Acomplex carbs
- Binsulins
- Csimple carbohydrates
19Which of the following are the mechanisms of action for the biguanides class?
- Adecrease glucose production from the liver
- Bcloses a K(ATP) channels on beta-cell plasma membranes
- Cincreases insulin sensitivity in muscle
- Ddecrease carbohydrate uptake in gut
20Which of the following are the mechanisms of action for the biguanides class?
- Acloses K(ATP) channels on beta-cell plasma membranes
- Bdecreases glucose production form liver
- Cincreases insulin sensitivity in muscle
- Ddecreases uptake in gut
21What is the physiological action of the Biguanides class?
- Aincreases insulin secretions
- Bdecreases hepatic glucose production
- Cincreases incretin levels
- Ddecreases glucagon secretion
22The maximum effective does for Metformin (Glucophage) is [blank_start]2000[blank_end] mg/day
- A2000
- B1500
- C1000
- D2250
23Metformin (Glucophage) has a BBW for lactic acidosis
- AVerdadero
- BFalso
24Iodinated contrast media, unstable HF, eGFR < 30 mL/min, hepatic dysfunction, dehydration, pre-renal azotemia, hypoxic states, CKD, and acidosis are all contraindications for [blank_start]Metformin (Glucophage)[blank_end]
- AMetformin
25[blank_start]Metformin (Glucophage)[blank_end] is the first line therapy for T2DM.
- AMetformin
26Starting metformin in patients with an eGFR between 45-50 mL/min/1.73m is not recommended.
- AVerdadero
- BFalso
27The following drugs belong to what class?
Glyburide (Micronase)
Glyburide (Micronized) - (Glynase)
Glipizide (Glucotrol)
Glimepiride (Amaryl)- ABiguanides
- BDDP-IV
- CTZD's
- DSulfonylureas
28Closure of the K(ATP) channels on beta-cell plasma membranes is the MOA for what class(es) of drugs?
- ASulfonylureas
- BTZDs
- CBile Acid sequestrants
- DMeglitinides
29Which of the following are ADR's for the sulfonylurea class?
- AHYPOglycemia
- BSIADH
- Cphotosensitivity
- DGI disturbances
- EB12 deficiency
- Finduced ovulation in PCOS
- Gsulfa-allergy
30[blank_start]Sulfonrylureas[blank_end] should NOT be used in elderly patients or patients with hepatic impairment
- ASulfonylureas
31Which of the sulfonylureas can be used during pregnancy?
- AGlyburide (Micronase)
- BGlipizide (Glucotrol)
- CGlimepiride (Amaryl)
32For the sulfonylurea class, 1/2 of the max dose is equal to 80% drug effectiveness
- AVerdadero
- BFalso
33Sulfonylureas can be used in combination with insulin
- AVerdadero
- BFalso
34Glynase can be interchanged with the drug Mirconase.
- AVerdadero
- BFalso
35Of the sulfonylureas, [blank_start]Glipizide (Glucotrol)[blank_end] should be utilized in patients with renal impariement.
- AGlipizide
36Which of the following drugs are Meglitinides?
- ANateglinide (Starlix)
- BPioglitazone (Actos)
- CRepaglinide (Prandin)
- DRosiglitazone (Avandia)
37Which of the following are ADR's for the Meglitinides?
- Aincreased fluid retention
- Bbladder cancer
- CHYPOglycemia
- Ddizziness
- EGI disturbances
38[blank_start]Meglitinides[blank_end] can be antidiabetic drug that can be reccommended for patients who are meal skippers.
- AMeglitinides
39Repaglinide (Prandin) is contraindicated with Gemfibrozil
- AVerdadero
- BFalso
40Which drugs listed below belong the Thiazolidinediones (TZDs) class?
- ASitagliptin (Januvia)
- BLinagliptin (Tradjenta)
- CPioglitazone (Actos)
- DRosiglitazone (Avandia)
41What is the MOA for the Thiazolidinediones class?
- Aclosure of the K(ATP) channels on the beta-cell membranes
- Bactivates dopaminergic receptors
- Cactivates GLP-1 receptors
- Dactivates the nuclear transcription factor PPAR-gamma
42What is the physiological action for the TZD class?
- Aincreases insulin secretion
- Bincreases insulin sensitivity in the skeletal muscle, adipocytes, and liver
- Cdecreases hepatic glucose production
43[blank_start]TZDs[blank_end] have a BBW warning for heart failure
- ATZDs
- BMeglitinides
- CDPP-IV inhibitors
- DBile Acid Sequestrants
44Select the ADRs of the TZD class
- Aincrease in fluid retention
- Bdizziness
- Cperipheral edema
- Dhepatotoxicity
- Ebladder cancer
- Ffractures
- Gmacular edema
45Which patient should not take TZDs for their diabetes?
- APatients with Class III or IV heart failure
- BPatient with Type 1 DM
- CPatients with the risk of bone fracture
46Of the TZD drugs, which has an improved lipid profile?
- APioglitazone (Actos)
- BRosiglitazone (Avandia)
47TZDs can be used in combination with Metformin
- AVerdadero
- BFalso
48[blank_start]Colesevelam (Welchol)[blank_end] is a bile acid sequestrant
- AColesevelam
49Binds bile acids in intestinal tract, increasing hepatic bile acid production and activates the farnesoid X receptor (FXR) in the liver is the MOA for what drug class?
- ADopamine agonist
- BBile acid sequestrant
- CDPP-IV inhibitors
- DBiguanides
50Indicate the physiological actions of the bile acid sequestrant class?
- ADecreases hepatic glucose production
- Bincreases incretin levels
- Cincreases insulin sensitivity
- Dactivates GLP-1 receptors
51Which of the following are ADR's for bile acid sequestrant?
- Aconstipation
- Bincreases in TG
- Cpancreatitis
- Ddecreases absorption of other medications
- EGI upset
- Ffatigue
52Bowel obstructions, TG > 500 mg/dL, and history of hypertriglyceridemia-induced pancreatitis are contraindications for ....
- ADopamine agonist
- BBile acid sequestrant
- CDPP-IV
- DSGLT-2
53Colesevelam (Welchol) can be approved for monotherapy
- AVerdadero
- BFalso
54Bromocriptine (Cycloset) belongs to what anti-diabetic drug class?
- ABile acid sequestrant
- BSGLT-2
- CDopamine agonist
- DGLP-1
55What is the MOA for Bromocriptine (Cycloset)?
- Ainhibits DPP-IV activity
- Bactivates GLP-1 receptors
- Cinhibits SGLT-2 in the proximal tubule
- Dactivates dopaminergic receptors
56What are the physiological actions for the Dopamine agonist class?
- Amodulates HYPOthalamic regulation of metabolism
- Bdecrease hepatic glucose production
- Cincreased incretin levels
- Dincreased insulin sensitivity
57Postural hypotension, headache, fatigue, hallucinations, psychotic disorder, pleural effusion, pulmonary fibrosis, and GI ulcers are the ADR's for what drug?
- AColesevelam (Welchol)
- BBromocriptine (Cycloset)
- CSitagliptin (Januvia)
- DLiraglutide (Victoza)
58Which of the following are contraindications for the Bromocriptine (Cycloset)?
- AHypersensitivity to ergot derivation or dopamine
- Blactation
- Csyncopal migraines
- Dsevere renal impairment
59Bromocriptine (Cycloset) is not approved for monotherapy.
- AVerdadero
- BFalso
60What drug class do the following drugs belong to?
Sitagliptin (Januvia)
Saxagliptin (Onglyza)
Linagliptin (Tradjenta)
Alogliptin (Nesina)- ADPP-IV
- BSGLT2 inhibitors
- CDopamine agonist
- DGLP-1 agonist
61Inhibits DPP-IV activity, increasing postprandial active incretin concentrations is the MOA for what drug class?
- AGLP-1
- BTZDs
- CBiguanides
- DDPP-IV inhibitors
62What are the physiological actions for the DPP-IV inhibitors? (select all that apply)
- Aincreases insulin secretion (glucose-dependent)
- Bincrease renal excretion of glucose
- Cdecrease glucagon secretion (glucose-dependent)
- Dslows gastric emptying
63Of the DPP-IV inhibitors, which one does not need to be adjusted in renal and hepatic impairment?
- AAlogliptin (Nesina)
- BLinagliptin (Tradjenta)
- CSaxagliptin (Onglyza)
- DSitagliptin (Januvia)
64ADR's for DPP-IV's include which of the following
- Aupper respiratory infection
- Bperipheral edema
- Cdecreased BP
- Dpancreatitis
- ESJS
- Frhabdomyolysis
65FDA warns that [blank_start]DPP-4 inhibitors[blank_end] may cause severe joint pain that can be severe or diabiling
- ADPP-4 inhibitors
- BSGLT-2
- CGLP-1 inhibitors
- DTZDs
66Which of the DPP-IV inhibitors can cause heart failure?
- ASitagliptin (Januvia)
- BSaxagliptin (Onglyza)
- CLinagliptin (Tradjenta)
- DAlogliptin (Nesina)
67The following drugs belong to what drug class?
Exenatide (Byetta)
Liraglutide (Victoza)
Abiglutide (Tanzeum)
Dulagultide (Trulicity)- AGLP-1 agonist
- BTZDs
- CDPP-IV
- DSGLT-2
68Select the physiological actions of the GLP-1 class
- Aincreases insulin secretion (glucose-dependent)
- Bdecreases glucagon (glucose-dependent)
- Cslows gastric emptying
- Dincreases satiety
69Of the GLP-1 agonist, which one can not be used if the CrCL is < 30 mL/min?
- AExenatide (Byetta)
- BLiraglutide (Victoza)
- CAbiglutide (Tanzeum)
- DDulaglutide (Trulicity)
70Of the GLP-1 inhibitors, which ones have a BBW warning for thyroid carcinoma?
- AExenatide (Byetta)
- BLiraglutide (Victoza)
- CAbiglutide (Tanzeum)
- DDulaglutide (Trulicity)
71History of pancreatitis, gastroparesis or GI disease, and caution in renal impairment are all contrainidcations for the [blank_start]GLP-1 agontist[blank_end]
- AGLP-1 agonist
- BDPP-IV
- CTZDs
- DSGLT-2
72The following drugs belong to what drug class?
Canagliflozin (Invokana)
Dapagliflozin (Farxiga)
Empagliflozin (Jardiance)- ASGLT-2 inhibitors
- BDPP-IV
- CBiguanides
- DMeglitinides
73Which of the following are ADR's for the SGLT-2 inhibitor drug class?
- Afemale & male genital mycotic infections
- Bincreased urination
- Cincreased BP
- Ddecreased BP
- Epancreatitis
- Fhypovolemia
- Ghyperkalemia
74Hypovolemia must be corrected prior to starting a SGLT-2 inhibitor
- AVerdadero
- BFalso
75Increased risk of bladder cancer and bone fracture with [blank_start]Dapagliflozin (Farxiga)[blank_end]
- ADapagliflozin (Farxiga)
- BCanagliflozin (Invokana)
- CEmpagliflozin (Jardiance)
76[blank_start]Empagliflozin (Jardiance)[blank_end] is assocaited with an increase in CV events
- AEmpagliflozin (Jardiance)
- BCanagliflozin (Invokana)
- CDapagliflozin (Farxiga)
77[blank_start]Canagliflozin (Invokana)[blank_end] may be associated with an increase in lower extremity amputations
- ACanagliflozin (Invokana)
- BDapagliflozin (Farxiga)
- CEmpagliflozin (Jardiance)
78Which drug classes target fasting BG only!
- ABiguanides
- BTZDs
- CSGLT-2
- DAmylinomimetics
79Which drug classes targets post-prandial blood glucose only!
- ABiguanides
- BSulfonylureas
- CAmylinomimetics
- Dalpha-glucosidase inhibitors
- Edopamine agonist
- FDPP-4 inhibitors
- Gmeglitinides
80What drug classes target BOTH fasting and postprandial BG levels?
- ASulfonylureas
- BTZDs
- CSGLT-2 inhibitors
- DBile acid sequestrants
81GLP-1 agonist, Metformin, SGLT-2, Amylinmimetics all cause [blank_start]weight loss[blank_end]
- Aweight loss
- Bweight gain
- Cweight neutral
82Metformin, alpha-glucosidase inhibitors, DPP-IV inhibitors all cause [blank_start]weight gain[blank_end]
- Aweight gain
- Bweight loss
- Cweight neutral
83Suflonylureas, Meglitinides, insulins, and TZDs all cause [blank_start]weight loss[blank_end]
- Aweight loss
- Bweight gain
- Cweight neutral
84Which drug classes are high cost agents?
- AGLP-1
- BSGLT-2
- CDPP-IV
- DInsulins
- EMetformin
- FSulfonylureas
- GTZDs
85Which drugs classes are low cost agents?
- AMetformin
- BSulfonylureas
- CDPP-IV
- DTZDs
- EGLP-1
- FSGLT-2
Información
- Descripción
- NAPLEX (Endo) Pharmacy Test sobre Anti-Diabetic Drugs Quiz , creado por Mark W. el 12/12/2016.
- Autor
- Mark W.
- Idioma
- English
- Visitas
- 2.790
- Etiquetas
- Valoración
- 4,0 de 5 · 1 valoración Valora este test