Tablets
Diapositivas del conjunto (12)
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- -A solid Preparation each containing a single dose of one or more active ingredients and usually obtained by compressing uniform volumes of particles
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- Convenient
- accurate
- stable
- Consistency
- cheap
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- poorly soluble drugs
- poor bioavailability
- local irritation
- harmful effects on GI tract
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- Convential
- Buccual
- coated
- effervescent
- controlled released
- Stamped
- Scored
- Sublingual
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- Content
- Content uniformity
- Reproducible drug release
- Disintegration time
- Dissolution rate
- Friability/Hardness
- Microbial Quality
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- Non-toxic
- Known Functionality
- Inactive in physiological conditions
- No idiosynchratic effects in the bodies
- Stable
- Reliable
- Reproducable supply
- Cheap/effective in cost
- Tasteless, Colourless and odourless
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- Powders compressed in a die
- Top Punch Pushes down and compresses the contents of the powder into the die
- Bottom punch ejects the contents of the Tablet out
- Powder needs to be treated with excipients for it to be optimumly removed
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- Flow must flow into the die in a reproducable manner
- Particles must cohere to eachother to form the tablet under a compressive force
- Tablet must be ejected from press with no
- Cracks
- Chips
- Capping
- Lamination
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- Dilutant
- Binding Agent
- Lubricants
- Glidants
- Disintegrants
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- Disintegrant types include:
- Water uptake facilitators
- Tablet-rupture promoters
- They cause the tablet to expand or rupture on contact with water, causing the tablet to break down
- Polymers: Structure improves water access to the tablet, swelling and breaking result
- Disintegrants can also react and form carbon dioxide gas bubbles, resulting in tablet rupture
- Examples of a disintegrant include Pregelatenised starch, PVP cross linked and carboxymethylcellulose
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- Helps the compressed compact be released from the die safely
- Too much lubricant reduces dissolution and/or tablet strength
- Examples include magnesium stearate and talc