Fichas
Week 9 Reproductive and Oncology Pharmacology
Fichas del conjunto (21)
- 1Oncology drug treatmentsmost non-specific cytotoxics, will target normal as well as cancer cells
cells most susceptible, rapidly dividing - 2Chemotherapy antibioticsactivate immune system to target cancer cells
- 3Combination chemotherapyalmost always used
2-3 drugs together intermittently
advantages: greater response rate, decrease side effects
Disadvantages: more time receiving treatment - 4Breast cancer treatmentAdjuvant chemotherapy is FEC-D
3 cycles of flurouracil, epirubicin, cyclophosphamide every 21 days
adverse effetcs, bone marrow toxicity, renal and hepatic toxicity - 5Nursing staff in cancer treatmentensure safety and correct administration
report adverse effetcs
safety and handling of cytotoxic drugs
psychological support for pts and families - 6Breast cancer treatmentsOestrogen receptor modulators
SERMS such as tamoxifen
monoclonal antibody against HER2 - trastuzumab - 7Breast cancer treatments side effectschemotherapy resistance, hair loss, nausea, vomiting, diarrhea, malnutrition, anaemia
- 8Female reproductive cycles- feedback controlOestrogen inhibits further FSH and LH release from anterior pituitary
Progestrone inhibits GnRH, FSH, LH secretion from hypothalamus and pituitary
Negative feed back cycles- key to effects of oral contraceptives - 9Oestrogens used clinicallyPrimary hypogonadism- lack of ovary function
Primary amenorrhoea- absence of menstruation
Preventing ovulation- Oral contraceptive pill with progestin
contraception- 20-50mcg/day
Replacement therapy HRT- 5-20mcg/day - 10Oestrogens for contraceptionprevent ovulation
natural and synthetic, 20-50mcg/day can be mono or multi-phasic - 11Oestrogen for post menopausal = HRTprevents vasomotor symptoms, and slows bone resorption
5- 10mcg/day= HRT, mixed results with benefits vs risks (breast cancer, blood clots) - 12Anti oestrogens used clinicallycancer treatments- tamoxifen
blocks oestrogen binding at breast tissue - 13Progestins used clinically contraceptioncontraceptions with oestrogen (COC)
or
Progesterone only (mini pill) for when COC contraindicated = high BP, clot risk, older age, breast feeding, smoker, also high dose for emergency contraception - 14Combination oral contraceptive (COC)most effective form of contraception
oestrogen and progestin
20-50mcg/day
used in 21 days active tabs
7 days inactive tabs - 15Side effects of COCweight gain
hypertension
nausea
flushing
dizziness
mood changes
amenorrhoea - 16Male reproductive systemcontrolled by hypothalamic GnRH=
Increase FSH (Gametogenesis)
LH (Sperm maturation), testosterone production
Testosterone= muscle and bone growth - 17Androgen clinical usesMale hypogonadism, aplastic anaemia, wasting cachexic states, (e.g. cancer/AIDS)
Anabolics - 18Anti- androgen clinical usesprostate cancer, stall precocious puberty
- 19Adverse effects of androgens male and femalemen- testicular atrophy, steility, gynaecomastia
Women- inhibition of ovulation, hirsutism, deepening of voice, alopecia, acne - 20Erectile dysfunctiondues to age, loss of libido, medication, disease
- 21Treatment of erectile dysfunctionPDE inhibitors
e.g. viagra (sildenafil, prolongs erectile vasodilatation and blood flow.
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- El usuario ha eliminado su información de asignaturas Fichas sobre Week 9 Reproductive and Oncology Pharmacology, creado por Usuario eliminado el 08/10/2017.
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- Creado por Elizabeth Then · 5 oct 2017
- Copiado por Elizabeth Then · 8 oct 2017
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