Lecture 2: Properties of solids

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Flashcards on Lecture 2: Properties of solids, created by jenny schneider on 31/07/2014.
jenny schneider
Flashcards by jenny schneider, updated more than 1 year ago
jenny schneider
Created by jenny schneider about 10 years ago
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Question Answer
True or False: crystalline solids are made up of repeating lattice units called unit cells True
Amorphous solids have a regular repeating arrangement of molecules in their structure True or False? False
What does crystal habit describe? The external shape of the crystal
What effects that are important to pharmaceutics can crystal habit have? different shape crystals may cause problems with flow of powder (e.g. from hopper in tableting) ability to inject a suspension will be harder with needle-like than plate-like shape crystals crystal habit can affect the ease of compression of solid into a tablet
What do we mean by polymorphism of a drug drug can exist as different forms that have different INTERNAL arrangement of molecules in the crystal
What is one technique we can use to detect polymorphism of a drug? X-ray diffraction
What effect can polymorphism of a drug have? Different polymorphs of same drug have different MP, solubility changing from one polymorph to another in a formulation may therefore change solubility and affect bioavailability
In general, if you have a hydrate form of a drug and an anhydrous form (anhydrate) which will be more soluble? anhydrate form
If you had a crystalline form of drug and an amorphous form of the same drug, which would usually be more soluble? amorphous form of drug
True or False co-crystals are two crystals of same drug joined together False: a co-crystal is made of drug plus another molecule which is usually H bonded to the drug
True or False A polymer consists of repeating units of small molecules called monomers True
Properties of polymers will vary with MW e.g. PEG 400 is liquid and PEG3350 is a solid True
Why would a drug be prepared as a solid dispersion? Solid dispersions are used to help improve the bioavailability of a poorly water soluble drug
Explain what happens when we have a simple eutectic mixture When we mix drug A and B together, they lower each others melting point. At a particular mix, the lowest melting point of mixture of A and B is reached (called eutectic point)
Give an example of a eutectic mixture Here are two: menthol and camphor prilocaine and lidocaine (used in EMLA cream)
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