Pharmacology of T2DM

Bhavi Mistry
Flashcards by Bhavi Mistry, updated more than 1 year ago
Bhavi Mistry
Created by Bhavi Mistry about 8 years ago
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under grad Endocrine Pharmacology Flashcards on Pharmacology of T2DM, created by Bhavi Mistry on 05/31/2013.

Resource summary

Question Answer
Metformin 1st line treatment + liver --> - GNG SE: GI disturbance, lactic acidosis
Sulphonureas 1st line treatment +SU Rs, K+ATP, +B cells -> Increased insulin release SE: Hypoglycaemia and weight gain
Insulin Late stage treatment Increases glucose uptake (liver, muscle, fat) SE: hypoglycaemia and weight gain
Thiazolidine diones (Rosiglitazone/Avonida) +PPAR gamma increasing gene transcription of Insulin Rs in fat, liver and muscle, increases insulin sensitivity, reduces FFAs in circulation SE: CVD?
Acarbose alpha glucosidase in intestine SE: GI disturbance
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