Haematology prac 1

sajedashah
Flashcards by sajedashah, updated more than 1 year ago
sajedashah
Created by sajedashah over 6 years ago
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Description

anaemia

Resource summary

Question Answer
Normocytes cells of normal size and appearance
Anisocytosis microcystosis/macrocytosis increase in range of red blood cell size associated with many conditions not a type of disorder itself
macrocytosis predominance of large cells associated with: premature release of RBC into circulation and defective cell replication seen in b12 and folate deficiencies
microytosis predominance of small cells associated with: deficiencies of haemabglobin production, reduced availability of iron or RBC damaged during production or in circulation
poikilocytosis irregular cell shapes may have sharp projections e.g. teardrop/helmet/burr cells many causes leads to defective production and damage to RBC
spherocytes do not show a pale centre and often smaller diameter spherical (ball) instead of discoid (flat) formed in peripheral circulation-they leave the BM discoid
schistocytes erythrocyte fragments caused by mechanical damage (haemolysis)
normochromic hypochromasia/polychromasia cells of normal colour-ie pale centre
hypochromasia low Hb content-pale staining of red cells large central area of palllour
polychromasia blue tint in stained red cell caused by immauture RBC containing ER or ribosomal material BM commonly compensates anaemia by premature release of RBC
Acanthocytes spur cell distorted cell with thornlinke projections a-thallasaemia
elliptocyte oval/eliptic cell
teardrop cell teardrop shaped poikilocyte found in myelofibrosis, metastatic marrow infiltration and myelodysplastic syndrome.
pencil cells elliptocyte caused by iron defiecient anaemia and thallasaemia
target cell dark/dense stain in middle, looks like archery target due to shift in erythrocyte:cholesterol equilibrium liver disease/thallasaemia/sickle cell occur sometimes in FEdeficient or post splenectomy
Heinz bodies denatured Hb due to oxidative damage normally all removed by spleen small no seen after splenectomy
Howell-Jolly bodies nuclear remenants normally removed by spleen seen after spenectomy, megoblastic and iron deficient anaemias and sometimes in leukaemia
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