Spectrum disorders

Simeon Crane
Flashcards by , created 2 months ago


Simeon Crane
Created by Simeon Crane 2 months ago
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Question Answer
Name two reasons bioavailability is often lower in children - Rapid metabolism - Distribution in a relatively larger extracellular fluid
Name 4 ideal formulation properties of medications used in the treatment of ADHD Long duration of action Rapid onset of action Ease of administration Dissipates rapidly
Name 4 ideal pharmacodynamic properties of drugs used in the treatment of ADHD Not potentially addictive Absence of 'rebound' effects No effect on appetite or growth Effective in treating associated symptoms
What is theory of mind? Where an individual does not understand that other people have their own plans, thoughts and points of view
How is lithium excreted? Through the kidneys
What is lithium administration during pregnancy associated with? Epstein's anomaly
What dosage form would be most appropriate to deliver a bitter-tasting, water-soluble drug which is readily hydrolysed and doesn't require a measurable dosage form? Coated tablet
Who has a higher concern about the danger of medicines? Parents or ? Parents
What would be the most appropriate dosage form for a bitter-tasting, water soluble drug which is readily hydrolysed and requires a measurable dosage form? Sprinkle oral granules
What class of drug is clomipramine? Tricyclic antidepressant
Name 3 adverse effects of stimulants used to treat ADHD - Insomnia - Decreased appetite - Altered mood
What is ADHD? A diverse behavioural syndrome characterized by the core symptoms of hyperactivity, impulsivity and inattention
What is the first line pharmacological treatment for ADHD? Methylphenidate
What is the mechanism of action of methylphenidate? Inhibits uptake of monoamines into the presynaptic neurone, thereby increasing dopamine 'hit' at post-synaptic receptor sites
What is Rapid Cycling BPAD? When the patient experiences 4 or more episodes within 12 months
Name the 3 appropriate scales used in BPAD - Mood disorder questionnaire (MDQ) - Young mania rating scale (YMRS) - Montgomery Asperg depression rating scale (MADRS)
Name 2 prophylactic agents used in BPAD Lithium Valproate
What is the name of the rating scale used to assess the severity of OCD? The Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
What is first line drug treatment for OCD SSRIs
What drug is second-line therapy for OCD? Clomipramine