18048266
Description
Flashcards by Simeon Crane, updated more than 1 year ago
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Created by Simeon Crane
over 6 years ago
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| Question | Answer |
| Name two reasons bioavailability is often lower in children | - Rapid metabolism - Distribution in a relatively larger extracellular fluid |
| Name 4 ideal formulation properties of medications used in the treatment of ADHD | Long duration of action Rapid onset of action Ease of administration Dissipates rapidly |
| Name 4 ideal pharmacodynamic properties of drugs used in the treatment of ADHD | Not potentially addictive Absence of 'rebound' effects No effect on appetite or growth Effective in treating associated symptoms |
| What is theory of mind? | Where an individual does not understand that other people have their own plans, thoughts and points of view |
| How is lithium excreted? | Through the kidneys |
| What is lithium administration during pregnancy associated with? | Epstein's anomaly |
| What dosage form would be most appropriate to deliver a bitter-tasting, water-soluble drug which is readily hydrolysed and doesn't require a measurable dosage form? | Coated tablet |
| Who has a higher concern about the danger of medicines? Parents or ? | Parents |
| What would be the most appropriate dosage form for a bitter-tasting, water soluble drug which is readily hydrolysed and requires a measurable dosage form? | Sprinkle oral granules |
| What class of drug is clomipramine? | Tricyclic antidepressant |
| Name 3 adverse effects of stimulants used to treat ADHD | - Insomnia - Decreased appetite - Altered mood |
| What is ADHD? | A diverse behavioural syndrome characterized by the core symptoms of hyperactivity, impulsivity and inattention |
| What is the first line pharmacological treatment for ADHD? | Methylphenidate |
| What is the mechanism of action of methylphenidate? | Inhibits uptake of monoamines into the presynaptic neurone, thereby increasing dopamine 'hit' at post-synaptic receptor sites |
| What is Rapid Cycling BPAD? | When the patient experiences 4 or more episodes within 12 months |
| Name the 3 appropriate scales used in BPAD | - Mood disorder questionnaire (MDQ) - Young mania rating scale (YMRS) - Montgomery Asperg depression rating scale (MADRS) |
| Name 2 prophylactic agents used in BPAD | Lithium Valproate |
| What is the name of the rating scale used to assess the severity of OCD? | The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) |
| What is first line drug treatment for OCD | SSRIs |
| What drug is second-line therapy for OCD? | Clomipramine |
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