med chem 2

lola_smily
Flashcards by , created over 4 years ago

Flashcards on med chem 2, created by lola_smily on 02/11/2015.

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lola_smily
Created by lola_smily over 4 years ago
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Question Answer
438aa52b-ce28-4f86-8529-897916b3032c.PNG (image/PNG) beta-D-Digitoxose sugar moiety of cardiac glycoside
2267d256-23cd-421a-bc69-ad7adcbc692b.PNG (image/PNG) beta-D-Glucose sugar moiety of cardiac glycoside
f07a433c-1809-41d0-a242-79817a7c5939.PNG (image/PNG) beta-L-Rhamnose sugar moiety of cardiac glycoside
92944abc-1986-4837-8026-0f7ffa7406c3.PNG (image/PNG) beta-D-Cymarose sugar moiety of cardiac glycoside
4e097dc7-4d13-4e78-9b8c-5db143b304df.PNG (image/PNG) digitoxigenin non sugar aglycone moiety of cardiac glycoside steroid structure cyclopentanoperhydrophenanthrene cardenolide (5 membered lactone ring) planr source
a9545816-a91b-424d-92ca-f5d7cfd7f492.PNG (image/PNG) digoxigenin non sugar aglycone moiety of cardiac glycoside steroid structure cyclopentanoperhydrophenanthrene more polar
5fed225a-44e4-4cf8-b1cf-28e4502d2637.PNG (image/PNG) strophanthidin non sugar aglycone moiety of cardiac glycoside steroid structure cyclopentanoperhydrophenanthrene
0e1c1c16-1cf4-460e-a429-95b109e8a032.PNG (image/PNG) gitoxigenin non sugar aglycone moiety of cardiac glycoside steroid structure cyclopentanoperhydrophenanthrene
aaa35a8b-532f-48b5-b7cc-84ea342b5c1e.PNG (image/PNG) ouabagenin non sugar aglycone moiety of cardiac glycoside steroid structure cyclopentanoperhydrophenanthrene
a1cc4948-dc17-4525-b5cd-426cfd1640de.gif (image/gif) bufadienolide non sugar aglycone moiety of cardiac glycoside steroid structure cyclopentanoperhydrophenanthrene 6 membered lactone ring animal source
82763909-7ff1-4c63-bd92-b53e7e7958af.PNG (image/PNG) lanatoside A cardiac glycoside digitalis lanata digitoxigenin+glucose-3-acetyl(digitoxose)3
e2f52445-5b12-4ed8-8750-3d5290233c42.PNG (image/PNG) digitoxin cardiac glycoside
98da238e-3fa2-40bf-a722-7c5b64734de5.PNG (image/PNG) digoxin cardiac glycoside
cbc41140-c81b-466c-8a35-9b7b8e6458c0.PNG (image/PNG) ouabain cardiac glycoside very polar not clinically used
db11f5ef-d9e1-42d8-a66c-58029d6a2bcc.PNG (image/PNG) inamrinone positive inotropic agents phosphodiesterase enzyme inhibitor thrombocytopenia metabolized in liver
053dfe52-04de-4425-a861-e3794fab86cd.PNG (image/PNG) milrinone positive inotropic agents phosphodiesterase enzyme inhibitor more potent less toxic unchanged excretion
57f9d083-e38a-448a-a93a-82adad415892.PNG (image/PNG) dobutamine positive inotropic agents beta 1-adrenoceptor agonists inactive orally and given IV
d68fdca3-8c44-4cd6-9272-3b6e3941ca4e.PNG (image/PNG) nitric-nitrate nitrovasodilator organic nitrate
1c296667-2558-4c48-9a7e-989e92d779fd.PNG (image/PNG) nitrous-nitrite nitrovasodilator organ nitrite
ab369d58-ba05-49b3-926d-1e692852e15b.PNG (image/PNG) amyl nitrite antianginal agent nitrovasodilator prodrug isopentyl nitrite give inactive metabolite volatile at RT most rapid onset/short duration of action insoluble in water/miscible with organic solvents
22a50f91-7db3-4cf3-98af-f2c7f5366b0e.PNG (image/PNG) glyceryl trinitrate (nitroglycerin) antianginal agent nitrovasodilator prodrug explosive in dynamite colorless oil volatile skin absorption
3ec370ca-7593-4138-be7b-ff23d9e86ce2.PNG (image/PNG) erythrityl tetranitrate antianginal agent nitrovasodilator prodrug solid slightly water soluble more soluble in organic solvents slower onset/long duration of action low volatility
8de99868-e7a3-4b22-8c63-03b4517b1776.PNG (image/PNG) pentaerythritol tetranitrate antianginal agent nitrovasodilator prodrug crystalline weakly insoluble in alcohol readily soluble in acetone powerful explosive
a4446cc5-80de-4c88-ae43-6dae25a7c5c1.PNG (image/PNG) isosorbide dinitrate antianginal agent nitrovasodilator prodrug solid water soluble give active metabolite (100% bioavailable)
6b70b718-00fc-4527-9d27-a3335a84242e.PNG (image/PNG) nifedipine antianginal calcium channel blocker DHP orally active/ metabolized decrease afterload reflex tachycardia
253e279b-f545-4437-aaf4-f1a26ffea148.PNG (image/PNG) amlodipine antianginal calcium channel blocker DHP orally active/ metabolized decrease afterload reflex tachycardia bioavailability: 60-90% DOA: 24h
8fee1524-a8e1-465b-b744-93ffdbaed82e.PNG (image/PNG) nicardipine antianginal calcium channel blocker DHP orally active/ metabolized decrease afterload reflex tachycardia
394827b4-842f-4e8b-a27b-d327dc761ff1.PNG (image/PNG) verapamil antianginal calcium channel blocker non DHP/ phenylalkylamine orally active/ metabolized by CYP3A4 and CYP2D6 decrease HR - inotropic, chronotropic, dromotropic
27cc2625-dff7-4863-8420-73d6953d55bc.PNG (image/PNG) bepiridil antiangina calcium channel blocker non DHP/ diarylaminopropylaminoether rarely used
ec7c2036-1aa7-40a6-b615-a55a9ed97ba9.PNG (image/PNG) diltiazem antianginal calcium channel blocker non DHP/ benzothiazepine orally active/ metabolized by hydrolysis decrease HR - inotropic, chronotropic, dromotropic
84dfa9bd-2413-40d5-842c-668125b2a241.PNG (image/PNG) noverapamil metabolite of verapamil by N-demethylation 30-50% active as parent drug
9fcd6d21-61f0-439c-945f-e3b82bf9bbc3.PNG (image/PNG) desacetyldiltiazem metabolite of diltiazem by hydrolysis of ester 30-50% active as parent drug
339177b2-e551-4513-baec-bc0252d8254c.PNG (image/PNG) dipyridamole antianginal coronary vasodilator antiplatelet activity non selective so rarely used
611010f8-4b29-49c1-8220-6fddca80350f.PNG (image/PNG) papaverine antianginal coronary vasodilator orally active antispasmotic non selective so rarely used
d7455fb9-9dc8-46bb-90ef-f67313be1e19.PNG (image/PNG) cyclandelate antianginal coronary vasodilator non selective so rarely used
71f0dadb-f6ef-4d2d-82fe-b9fbc9adbd7f.PNG (image/PNG) MPPP (designer heroin) active opioid agonist reversed ester of meperidine phenylpiperidine synthetic analgesics
da5d63aa-d6fa-475f-b964-c62bd18ccb93.PNG (image/PNG) nisentil (alpha-prodine) phenylpiperidine synthetic analgesics
d82919f1-59ff-4e21-8710-65549ed0f052.PNG (image/PNG) demerol (meperidine) active opioid agonist phenylpiperidine synthetic analgesics
f11c14b5-d906-4f16-a560-d6941f637819.PNG (image/PNG) MPTP N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine byproduct of MPPP metabolized orally/IV/inhalation by MAO-B lead to parkinsonism
3160b1c3-e83c-4f37-b7c0-ed624f809f55.PNG (image/PNG) MPP+ 1-methyl-4-phenylpyridinium toxic irreversible damage of DA neurons metabolite of MPTP
b98c3a3d-4d2a-47e3-b9a6-ac3834dd18bf.PNG (image/PNG) benztropine mesylate anticholinergic (antimuscarinic) agent synthetic centrally acting limited use given with dopaminergic therapy severe central and peripheral side effects
4acda9b3-6839-43e3-be70-4c56466c030a.PNG (image/PNG) trihexyphenidyl hydrochloride anticholinergic (antimuscarinic) agent synthetic centrally acting limited use given with dopaminergic therapy severe central and peripheral side effects salt/pH dependent
9115d15b-6018-4479-9494-b3dfaa6d35ae.PNG (image/PNG) procyclidine hydrochloride anticholinergic (antimuscarinic) agent synthetic centrally acting limited use given with dopaminergic therapy severe central and peripheral side effects salt/pH dependent
35cadab6-4227-456c-a85a-e9e15b5887f9.PNG (image/PNG) biperiden hydrochloride anticholinergic agent synthetic salt pH dependent
d662e365-d6cd-4ba7-9bba-af287911361b.PNG (image/PNG) diphenhydramine hydrochloride antihistamine
72b76eaa-1a54-484f-8c02-75a38e5b242a.PNG (image/PNG) orphenadrine hydrochloride antihistamine centrally acting limited use given with dopaminergic therapy severe central and peripheral side effects
5b3bd164-60d5-4688-9ea4-c91b5b738c73.PNG (image/PNG) L-DOPA levo dihydroxyphenylalanine precursor of dopamine absorbed in GI and enters brain by active transport less basic given orally alone 1-3% to brain with carbidopa 10%
836d221e-dbde-4ca7-8bda-e74c5c444be3.PNG (image/PNG) dopamine 3,4-dihydroxyphenylethylamine highly basic (doesn't cross the brain) rapidly metabolized
34dabb3d-f132-4f25-9082-8db4af518a1f.PNG (image/PNG) 3-methoxy-4-hydroxy phenylalanine metabolite of L-DOPA by COMT
47d3e0b6-0bd5-4921-b778-b014c47173aa.PNG (image/PNG) 3,4-dihydroxyphenylacetic acid metabolite of dopamine by MAO
b275fd71-5f20-4990-b06f-ab7565fe2fd9.PNG (image/PNG) vanillylmandelic acid (VMA) final metabolite of L-DOPA
fad3b702-1255-463e-9ead-35068f3dfe63.PNG (image/PNG) carbidopa decarboxylase inhibitor delivers more L-DOPA to brain acts peripherally doesn't cross the BBB
560756ce-0f2e-4ba7-8314-a90e5e14dbfe.PNG (image/PNG) selegiline first generation irreversible MAO-B inhibitor orally metabolized gives metamphetamine side effect: vasoconstriction, hallucination
69d8cb24-d3c2-4cdd-8f35-0b9c75867fd3.PNG (image/PNG) rasagiline second generation irreversible MAO-B inhibitor orally metabolized to 1-aminoindan no side effects
1d45f637-2f6b-44c8-9f3f-2fe81b35a30d.PNG (image/PNG) tolcapone reversible non specific COMT inhibitor long acting (8-12h) centrally and peripherally acting nausea, hallucination hepatic failure
18810c66-8b9d-4a9b-9d9a-9bb3edbffb09.PNG (image/PNG) entacapone reversible non specific COMT inhibitor short acting (2h) mostly peripherally nausea,hallucination
1078858a-77a2-4bfa-83e9-f557166ff0c8.jpg (image/jpg) amphetamine metabolite of metamphetamine (metabolite of selegiline) causes side effects of selegiline
468c830e-dd94-46f8-a5b3-6d1dbf763cf7.png (image/png) metamphetamine metabolite of selegiline
8bab3c14-e8b0-4853-bf8b-0a6341f4f3cc.gif (image/gif) amantadine primary amine admantane derivative dopamine releasing agent inhibit dopamine reuptake protonated/lipophilic less potent short lived benefits (few weeks) reversible side effects: insomnia hallucination, depression, confusion, agitation
4af30b32-8bba-4a08-b83f-e8a6fd670396.png (image/png) Memantine admantane derivative dopamine releasing agent inhibit dopamine reuptake
dda06b75-c5de-4b9e-bb3a-49f67700de73.PNG (image/PNG) quinidine antiarrhythmic class 1A alkaloid (cinchona bark) basic hepatic metabolism/unchanged renal excrection for supraventricular tachycardia inhibit renal excretion of digoxin - inotropic/anticholinergic act/peripheral alpha adrenergic SE: GI disturbances
0a573b56-8f68-453e-8161-2974ac4ca0c9.PNG (image/PNG) o-demethylquinidine metabolite of quinidine active by partial hepatic metabolism
5c1415e9-633d-4d66-ab2c-1e5fdaf40804.PNG (image/PNG) oxydihydroquinidine metabolite of quinidine active by partial hepatic metabolism
476db2d3-de55-4487-bd90-ced83785b8a7.PNG (image/PNG) procainamide antiarrhythmic class 1A from procaine gd GI absorbance (70-80% biovailability) liver metabolism unchanged renal excretion for ventricular tachycardia SE: lupus syndrome (20-30%)
6d8739d6-ac17-4389-9ea3-952e7a71d220.PNG (image/PNG) n-acetylprocainamide metabolite of procainamide active
74de8524-5085-48c8-a8a4-8ee74932069a.PNG (image/PNG) p-aminobenzoic acid metabolite of procainamide
c2b8edd0-c186-4ef8-b332-f7add6e3e54d.PNG (image/PNG) metabolite of procainamide
ff122a59-b286-4b98-9ba3-19c03803ce69.PNG (image/PNG) disopyramide antiarrhythmic class 1A phosphate salt rapid and highly GI absorbance liver metabolism (50%)-> active(n-deacetylation) renal excretion (50%) for ventricular and atrial arrhythmias SE: anticholinergic effects
58bf3834-83fb-4092-925d-bbec9effd057.PNG (image/PNG) lidocaine antiarrhythmic class 1B local anesthetic first pass metabolism (n-dealkylation) SE: emesis, convulsion
91865720-12e3-410f-81cd-32f808086868.PNG (image/PNG) monoethylxylidine metabolite of lidocaine give glycine xylidide active CNS effect
b2fc0b76-7e52-4206-bd76-5afd62bda951.PNG (image/PNG) metabolite of lidocaine
9528a33b-3644-4bba-ab73-730fdcef55a3.PNG (image/PNG) metabolite of lidocaine
5dd29113-3dd6-49a7-bdd0-2dad84c385af.PNG (image/PNG) tocainide antiarrhythmic class 1B orally active/ absorbed (bcz of alpha methyl) slow metabolism for emergency ventricular arrhythmias SE: GI disturbance, CNS effects
1f47e1e8-b2db-4e5a-8cd2-81f626d0d444.PNG (image/PNG) mexiletine antiarrhythmia class 1B xylyloxy and ethylamine derivative hydrolysis --> ether given orally and IV renal, hepatic elimination like lidocaine and tocainamide p-hydroxylation and hydroxymethylation (inactive)
a310dde4-7bed-43c8-9ddc-f43013da3d98.PNG (image/PNG) phenytoin antiarrhythmia class 1B anticonvulsant orally active IV use p-hydroxylation (inactive) for atrial and ventricular arrhythmias
480cddb7-3386-4e35-afc9-3f5c34d51eec.PNG (image/PNG) flecainide antiarrhythmia class 1C fluorinated benzamide derivative acetate form oral absorption liver metabolism (50%)--> m-O-dealkylation (active) SE: aggravation of arrhythmias, blurred vision, headache, nausea, GI disturbance
098349c1-2a10-4d7c-b076-cd65f053c467.PNG (image/PNG) propafenone antiarrhythmic class 1C local anesthetic orally, IV GI absorption hepatic metabolism by CYP2D6
96d625eb-8fd9-4d3b-a1d3-3b0f7d71d7af.PNG (image/PNG) moricizine antiarrhythmia class 1C phenothiazine orally short half-life but effect lasts hours (active metabolite)
45526354-5ce4-49ce-89b1-1d6d3b1b91cb.PNG (image/PNG) encainide antiarrhythmia class 1C not used
6e14f827-2140-4b36-bcb2-8d721d90272c.PNG (image/PNG) ibutilide antiarrhythmic class 3 methanesulfonanilide derivative no beta adrenergic blocking activity only by IV infusion
912f9139-e007-4b3f-8c0c-51ce1b3e1c7b.PNG (image/PNG) bretylium tosylate antiarrhythmic class 3 adrenergic neuronal blocking agent antihypertensive given IV for life threatening cases of ventricular arrhythmia
d69988a7-6e97-47a3-a7f6-762989b0c4b3.PNG (image/PNG) amiodarone antiarrhythmia class 3 coronary vasodilator iodine containing agent--> affect thyroid hormone activity (hypo and hyperthyroidism) t1/2 = 25d (very long) for life threatening ventricular arrhythmia
cf035c9c-0ac5-424d-8769-b158e6301397.PNG (image/PNG) dofetilide antiarrhythmic class 3 bis-methanesulfonanilide derivative more potent GI absorbtion (96-100% bioavailability) protein binding 60-70% metabolized by CYP3A4 (dealkylation, n-oxydation)--> inactive unchanged excretion (80%)
8628711c-7770-4587-a93a-d8daa4ffdf37.png (image/png) Sotalol antiarrhythmic class 3 methanesulfonanilide derivative non selective beta blocker
66c2e187-9e09-4f98-a9de-9eece4266c3a.PNG (image/PNG) verapamil antiarrhythmic class 4 slows phase 4 slow SA node firing and conduction to AV node
0cddf60d-3967-480c-847c-21384d91403e.PNG (image/PNG) diltiazem antiarrhythmic class 4 slows phase 4 slow SA node firing and conduction to AV node
6dcd8145-1d73-4ad7-9e5e-69480763641d.PNG (image/PNG) benazepril RAS inhibitor ACEI prodrug active undergoes glucuronidation DOA= 24h renal excretion SE: hypotension, hyperkalemia,dry cough, taste disturbance, headache, nausea, diarrhea, angioedema, acute renal failure
59c4b094-ac4d-4023-9995-a200ed187f9b.PNG (image/PNG) moexipril RAS inhibitor ACEI prodrug active renal, fecal excretion DOA= 24h SE: hypotension, hyperkalemia,dry cough, taste disturbance, headache, nausea, diarrhea, angioedema, acute renal failure
6453c481-d476-4794-adf3-783528a31d82.PNG (image/PNG) captopril RAS inhibitor ACEI active renal excretion DOA= 6-12h gd lipid solubility acidic gives dimer SE: hypotension, hyperkalemia,dry cough, taste disturbance, headache, nausea, diarrhea, angioedema, acute renal failure
6fc61c56-8288-4a1a-a4e3-b31bbd172168.PNG (image/PNG) perindopril RAS inhibitor ACEI prodrug active renal excretion DOA= 24h SE: hypotension, hyperkalemia,dry cough, taste disturbance, headache, nausea, diarrhea, angioedema, acute renal failure
dd89cfb5-19cf-432f-8154-784fb714f709.PNG (image/PNG) enalapril RAS inhibitor ACEI prodrug active hepatic metabolism renal excretion DOA= 24h SE: hypotension, hyperkalemia,dry cough, taste disturbance, headache, nausea, diarrhea, angioedema, acute renal failure
56d87f56-8ca0-4e38-a96a-b3c0b13448d9.PNG (image/PNG) enalaprilat RAS inhibitor ACEI active given IV gd lipid solubility renal excretion DOA= 6h SE: hypotension, hyperkalemia,dry cough, taste disturbance, headache, nausea, diarrhea, angioedema, acute renal failure
0944e4f0-bda3-4886-970d-f2de09c9e789.PNG (image/PNG) quinapril RAS inhibitor ACEI prodrug active renal excretion DOA= 24h SE: hypotension, hyperkalemia,dry cough, taste disturbance, headache, nausea, diarrhea, angioedema, acute renal failure
115097a6-2db0-4d8b-a027-6dd1ecad45fe.PNG (image/PNG) fosinopril sodium RAS inhibitor ACEI prodrug active acidic renal, hepatic excretion DOA= 24h SE: hypotension, hyperkalemia,dry cough, taste disturbance, headache, nausea, diarrhea, angioedema, acute renal failure
8a95c42d-104b-42b2-bcbe-59719b0504a1.PNG (image/PNG) ramipril RAS inhibitor ACEI prodrug active do glucuronidation, cyclization-> inactive renal excretion DOA= 24h SE: hypotension, hyperkalemia,dry cough, taste disturbance, headache, nausea, diarrhea, angioedema, acute renal failure
daea3697-3e5f-4773-89fa-7a0e82da1ca1.PNG (image/PNG) lisinopril RAS inhibitor ACEI active gd lipophilicity renal excretion DOA= 24h SE: hypotension, hyperkalemia,dry cough, taste disturbance, headache, nausea, diarrhea, angioedema, acute renal failure
685bb8ca-71b1-464d-bd90-2b19dff3fc12.PNG (image/PNG) trandolapril RAS inhibitor ACEI prodrug active renal,fecal excretion DOA= 24h SE: hypotension, hyperkalemia,dry cough, taste disturbance, headache, nausea, diarrhea, angioedema, acute renal failure
b990599c-54d7-496e-95f9-21a08a3b9db6.PNG (image/PNG) disulfide dimer metabolite of captopril inactive
de71a6b6-4550-4748-997e-efdf7c1e9a79.PNG (image/PNG) captopril cysteine disulfide metabolite of captopril inactive
ba378ad0-cbe1-4f55-8c65-b8c8964837da.PNG (image/PNG) glucuronide conjugate metabolite of benazepril
13149fa3-39da-499c-aa60-11f179b6e030.PNG (image/PNG) diketopiperazine metabolite metabolite of ramapril inactive
5e8e7d13-8e99-4617-aff0-33c8a3f4fffa.PNG (image/PNG) valsartan RAS inhibitor angiotensin 2 receptor blocker (ARB) competitive antagonist tetrazol derivative orally active renal elimination SE: same as ACEI but no dry cough, taste disturbances, angioedema
d4780337-da71-4cd9-8a39-9ac9a2bfa304.PNG (image/PNG) irbesartan RAS inhibitor angiotensin 2 receptor blocker (ARB) competitive antagonist tetrazol derivative orally active fecal, renal elimination SE: same as ACEI but no dry cough, taste disturbances, angioedema
689ab49e-5454-438e-a9b3-c833361b5bc3.PNG (image/PNG) telmisartan RAS inhibitor angiotensin 2 receptor blocker (ARB) competitive antagonist orally active fecal elimination SE: same as ACEI but no dry cough, taste disturbances, angioedema
4682d792-d31e-4f33-90cc-f42212c0d4a2.PNG (image/PNG) losartan RAS inhibitor angiotensin 2 receptor blocker (ARB) competitive antagonist tetrazol derivative orally active metabolized into active fecal, renal elimination SE: same as ACEI but no dry cough, taste disturbances, angioedema
31c84684-3b0a-4c4f-843b-98cf5b79fa7e.PNG (image/PNG) candesartan cilexetil RAS inhibitor angiotensin 2 receptor blocker (ARB) competitive antagonist tetrazol derivative prodrug metabolized into active fecal, renal elimination SE: same as ACEI but no dry cough, taste disturbances, angioedema
6d5e29f4-a98d-471a-82f4-744d28844533.PNG (image/PNG) olmesartan medoxomil RAS inhibitor angiotensin 2 receptor blocker (ARB) competitive antagonist tetrazol derivative prodrug metabolized into active fecal, renal elimination SE: same as ACEI but no dry cough, taste disturbances, angioedema
65174d6d-4a88-4e4d-a686-3e77c7ba4d5b.PNG (image/PNG) eprosartan RAS inhibitor angiotensin 2 receptor blocker (ARB) competitive antagonist orally active fecal, renal elimination SE: same as ACEI but no dry cough, taste disturbances, angioedema
e7a44927-5b56-4904-92b8-ed7e3edea332.PNG (image/PNG) EXP-3174 metabolite of losartan by CYP3A4 active non competitive antagonist tetrazol derivative
ceaf0abc-25ed-4a56-9e90-e86dfdc1cc9d.PNG (image/PNG) mannitol osmotic diuretics very polar given IV if orally--> osmotic diarrhea
4b35b3a6-a140-4ef6-82e2-3f8c97d7d72a.PNG (image/PNG) sorbitol osmotic diuretics very polar given IV if orally--> osmotic diarrhea
3e08694a-ac10-48ba-955f-2f101a6df043.PNG (image/PNG) isosorbide osmotic diuretics given orally
654070ea-2bcb-4af7-946a-af8c48d3aec9.gif (image/gif) urea osmotic diuretics given IV unpleasant taste
83293677-afeb-46db-b181-eca92ab9abae.PNG (image/PNG) acetazolamide diuretics carbonic anhydrase inhibitors arylsulfonamide for glaucoma cause hypokalemia and metabolic acidosis
cd45d6f0-cbbc-454e-ae58-a9b928bfcd1a.PNG (image/PNG) methazolamide diuretics carbonic anhydrase inhibitors arylsulfonamide for glaucoma cause hypokalemia and metabolic acidosis
88974cd0-3d32-4897-a0dc-dddfed7bc1eb.PNG (image/PNG) ethoxzolamide diuretics carbonic anhydrase inhibitors arylsulfonamide for glaucoma cause hypokalemia and metabolic acidosis
3ab6d7b9-8914-4ffe-91dc-f79d1c89b4ef.PNG (image/PNG) dichlorphenamide diuretics carbonic anhydrase inhibitors arylsulfonamide for glaucoma cause hypokalemia and metabolic acidosis
50daf582-2476-45f2-9480-ea8552d765ff.PNG (image/PNG) benzene-1,3-disulfonamide aryl sulfonamide derivative
7bba23f7-62fe-4419-b819-191a61368d50.PNG (image/PNG) aminochlorphenamine diuretics benzothiadiazine (thiazide)
410f7655-0f9c-4b69-8a4d-37720c1f7d27.PNG (image/PNG) 6-chloro-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide diuretics benzothiadiazine (thiazide)
1272c82b-4a9e-4428-a52e-bb84d7ed7079.PNG (image/PNG) quinethazone diuretics thiazide-like quinazolinone derivative orally active long DOA (18-24h)
6632f130-c2b4-4d94-8ab9-b92ca22cea99.PNG (image/PNG) metolazone diuretics thiazide-like quinazolinone derivative orally active long DOA more potent
df12e4a3-791e-4e9e-a11f-3f7cedd06785.PNG (image/PNG) chlorthalidone diuretics thiazide-like phthalamidine derivative orally active long DOA (48-72h)
2e7de2fd-c7ec-49b2-9f60-15d50826729b.PNG (image/PNG) indapamide diuretics thiazide-like indoline derivative orally active long DOA (24-36h) potent
faa52ba0-ddd9-4c6e-90ad-9640ba182884.PNG (image/PNG) furosemide diuretic loop diuretic orally active quick onset of action (30min) short DOA (6h) SE: electrolyte and fluid imbalance, hypokalemia, hyperurecemia, ototoxicity, hypersensitivity
4c869d38-74f8-4b24-a40b-2bb21dd129f6.PNG (image/PNG) 5-sulfamoyl-anthranilic acid diuretic loop diuretic orthoaminobenzoic acid
530ed2cc-4e36-4aa7-bb43-7f25fc636407.PNG (image/PNG) bumetanidediuretic loop diuretic 5-sulfamoyl-3-aminobenzoic acid derivative more potent (50X) orally active quick onset of action (30min) short DOA (6h) SE: electrolyte and fluid imbalance, hypokalemia, hyperurecemia, ototoxicity, hypersensitivity
632d9d3e-df0c-442f-a166-fb66494c4179.PNG (image/PNG) torsemide diuretic loop diuretic 4-amino-3-pyridine-sulfonylurea derivative orally active quick onset of action (30min) short DOA (6h) SE: electrolyte and fluid imbalance, hypokalemia, hyperurecemia, less ototoxicity, hypersensitivity
013df72d-11d2-4121-8e5e-2ab04ce75852.PNG (image/PNG) ethacrynic acid diuretic loop diuretic phenoxyacetic acid derivative orally active quick onset of action (30min) short DOA (6h) SE: electrolyte and fluid imbalance, hypokalemia, hyperurecemia, greater ototoxicity, hypersensitivity, GI disturbances
ee6461c0-b5e8-4d23-8291-35611864bc1f.PNG (image/PNG) spironolactone diuretic potassium sparing agent aldosterone receptor antagonist steroid moiety orally active extensive first pass metabolism t 1/2= 1.4h short onset (17-72h)/long DOA(2-3d) SE: hyperkalemia, GI disturbances, steroid related (gynecomastia, breast tenderness...)
02084105-515c-49ca-a32a-9583fa27c35c.PNG (image/PNG) canrenone diuretic potassium sparing agent aldosterone receptor antagonist steroid moiety orally active metabolite of spironolactone t 1/2=16.5 h SE: hyperkalemia, GI disturbances, steroid related (gynecomastia, breast tenderness...)
4af2c882-ae5b-4abf-8b13-d40d3922b2ce.PNG (image/PNG) canrenoic acid metabolite of canrenone inactive
c76eba42-10c8-4f61-bc11-4433f0d63793.PNG (image/PNG) elprenone diuretic potassium sparing agent aldosterone receptor antagonist steroid moiety orally active extensive first pass metabolism t 1/2= 5h short onset (17-72h)/long DOA(2-3d) SE: hyperkalemia, GI disturbances, steroid related (gynecomastia, breast tenderness...)
2714087a-ba92-4db7-b7dd-a1fa0a2cb8e3.PNG (image/PNG) triamterene diuretic potassium sparing agent non-aldosterone receptor antagonist 2,4,7-triamino-6-phenylpteridine active incomplete absorbtion extensive metabolism into active (20% excreted unchanged, 80% metabolised t 1/2= 4h SE: hyperkalemia, renal stones
b2a5def1-f4f9-4ad3-ae53-a9d6f81481e6.PNG (image/PNG) amiloride diuretic potassium sparing agent non-aldosterone receptor antagonist aminopyrazine or pyrazinoly guanidine active mostly charged incomplete absorbtion renal excretion unchanged t 1/2= 21h SE: hyperkalemia
5f534ad5-1c27-42a2-b52d-d615f81fa820.png (image/png) antodyne
06165efd-1b1b-4007-a885-18eda56da3a5.PNG (image/PNG) apomorphine
8d8fa0b5-ce45-44e8-b7e4-0d8a5a512a33.PNG (image/PNG) baclofen
29f8a571-ce08-4776-ab23-a494d253a8f3.PNG (image/PNG) bromocriptine(parlodel)
fbb8db3e-cef4-4046-914b-2cbd113106a1.jpg (image/jpg) carisoprodol(rela soma)
016b171a-279a-48f4-903b-462d4c0639b6.PNG (image/PNG) dantrolene sodium (dantrium)
3f3e4792-7e88-470c-bddd-f207aac17ee7.png (image/png) diazepam
5747dde9-5c73-49da-91e7-04994e6cd1e7.PNG (image/PNG) mephenesin
6e716f8b-da0a-46ab-ba73-cf11fd0e72fe.png (image/png) meprobamate (equanil)
8bce891c-df56-4c4f-8093-eacd96aa534f.PNG (image/PNG) pergolide (permax)
ac5e5a29-02aa-4df4-aaa0-cadf1f891838.PNG (image/PNG) ropinirol (requip)
917d2f45-ecfc-47f6-a9bb-4de8cb3f8812.PNG (image/PNG) S-Pramipexole (mixapex)