med chem 2 exam 2

Question	Answer
Image: a2e6e1dd-0ca8-445c-8161-1a57b98deeb2.PNG (image/PNG)	histidine
Image: bb78cbe0-a869-4549-8cc7-1bbbe3b0f55e.PNG (image/PNG)	histamine
Image: 99f62484-4e40-4616-a0d5-734b11701dbe.PNG (image/PNG)	khellin antihistaminic inhibit histamine release chromone moiety from ammi visnaga bronchodilatory effect (don't reverse bronchoconstriction)
Image: 9d7277f2-c534-4f5a-91d5-bc1fcef137b5.PNG (image/PNG)	cromolyn sodium antihistaminic inhibit histamine and SRS-A release (locally) bis-chromone no bronchodilatory and antihistaminic effects strictly prophylactic low oral bioavailability (poor absorption) by inhalation (for allergic rhinitis) topically: eye drops (for allergic conjunctivitis) 5-30 min before attack if chronic use: tolerance
Image: b1a36ce4-21d0-4ab4-9ae6-52cdb6247ec6.PNG (image/PNG)	nedocromil sodium antihistaminic inhibit histamine release chromone derivative by inhalation: aerosol (for prophylaxis of asthma) ophthalmic solution (for seasonal, perennial allergic conjunctivitis)
Image: 56457feb-e2db-40b4-8fb3-40fc1c795ed8.PNG (image/PNG)	lodoxamide antihistaminic mast cell stabilizer (inhibit immediate hypersensitivity reaction) topically: eye (for conjunctivitis)
Image: 3f5fa4e8-f802-4bd2-b060-c0fe09237721.PNG (image/PNG)	pemirolast potassium antihistaminic inhibit histamine release pyrimidone
Image: 21226924-382d-4609-9922-649f63ebfdab.PNG (image/PNG)	phenbenzamine H1 antihistaminic ethylenediamine SE: sedation, drowsiness, impair mental activity
Image: 93893dc5-4a26-42a5-a2be-928e0a5edf5f (image/png)	Tripelennamine H1 antihistaminic ethylenediamine SE: sedation, drowsiness, impair mental activity
Image: 5e6997d1-c0ae-46b5-9602-bd972ea317bf (image/png)	pyrilamine H1 antihistaminic ethylenediamine local anesthetic effect (tongue numbness) SE: sedation, drowsiness, impair mental activity
Image: 96889815-631d-4616-9cef-f694583c4da5 (image/png)	thonzylamine H1 antihistaminic ethylenediamine SE: sedation, drowsiness, impair mental activity
Image: 3f16a2b0-5777-4944-8e82-3a870467a547 (image/png)	methapyrilene H1 antihistaminic ethylenediamine SE: sedation, drowsiness, impair mental activity
Image: 949dcf60-4b20-4762-9900-8891a5242393.PNG (image/PNG)	antazoline H1 antihistaminic ethylenediamine SE: sedation, drowsiness, impair mental activity
Image: 6d017d6a-bd2e-499b-a566-8bcd70b9910f (image/png)	Diphenhydramine H1 antihistamine ethanolamine ether antihistaminic, antiemetic, antitussive, marked sedation, anticholinergic, antidyskinetic SE: sedation, drowsiness
Image: 4c99039a-1960-447e-ba56-7d1f6cc8f43e (image/jpg)	bromodiphenhydramine H1 antihistamine ethanolamine ether more lipid soluble, more potent antihistaminic, antiemetic, antitussive, marked sedation, anticholinergic, antidyskinetic SE: sedation, drowsiness
Image: 66e9bd3b-36ac-4c5a-a708-db24d6ca663d (image/jpg)	chlorodiphenhydramine H1 antihistamine ethanolamine ether more lipid soluble, more potent antihistaminic, antiemetic, antitussive, marked sedation, anticholinergic, antidyskinetic SE: sedation, drowsiness
Image: 15527e07-a100-4f39-a680-07d41d75713a (image/png)	Doxylamine H1 antihistamine ethanolamine ether most potent CNS depressant hypnotic agent no abuse potential SE: sedation, drowsiness
Image: 701273e1-71b3-4b6f-9da1-983dcf3b8068 (image/png)	Carbinoxamine H1 antihistamine ethanolamine ether potent - (rotoxamine)> + (available as racemic mixture) SE: sedation, drowsiness
Image: 3493acad-e5bb-492b-b84d-b378e00efc31.PNG (image/PNG)	clemastine H1 antihistamine aminoalkyl ether RR more potent long DOA less anticholinergic less sedation
Image: d41e4e30-7c94-40c6-a929-e74fbef6398e.PNG (image/PNG)	clemastine H1 antihistamine aminoalkyl ether RR more potent long DOA less anticholinergic less sedation
Image: c92ea610-0359-491e-b843-193ba8b2bf5c.PNG (image/PNG)	setastine H1 antihistaminic aminoalkyl ether
Image: 71229c9d-f8bb-48c5-8415-aabf3b220ba7 (image/png)	cyclizine H1 antihistamine piperazine derivative for nausea, vomiting (from motion sickness and radiation sickness) cyclizine lactate IM injection moderately potent prolonged DOA anticholinergic effects
Image: 7d2acce9-62fc-41f2-9f9a-c19528586f7f (image/png)	Chlorcyclizine H1 antihistamine piperazine derivative antiallergic (for urticaria and hay fever) more lipophilic moderately potent prolonged DOA anticholinergic effect
Image: 52b8e96a-5575-46e7-9ba2-ec881d15da6f (image/png)	Hydroxyzine H1 antihistaminic piperazine derivative marked sedation antiemetic, antiallergic (for pruritis) at high dose: for anxiety and emotional stress moderately potent prolonged DOA anticholinergic effects
Image: f1443488-72ef-41a2-8441-b7b798b04ba5 (image/png)	Cetirizine H1 antihistamine piperazine derivative 2nd generation ionized --> less absorbed antinauseant moderately potent prolonged DOA anticholinergic effects
Image: c416301f-c511-4f53-98ca-021dc9901ad5 (image/jpeg)	Meclizine H1 antihistamine piperazine derivative for nausea (from motion sickness and radiation sickness) moderately potent prolonged DOA anticholinergic effects
Image: d77d9eaf-31a2-4758-bd97-a486b58e8dea (image/png)	buclizine H1 antihistamine piperazine derivative for nausea (from motion sickness and radiation sickness) moderately potent prolonged DOA anticholinergic effects
Image: e4d7fdac-cd7b-4fe0-8dcd-fe00208ae3d9 (image/jpg)	oxatomide H1 antihistamine piperazine derivative antimuscarinic, mast cell stabilizer (less release of histamine) moderately potent prolonged DOA anticholinergic effects
Image: 7f3514a1-c985-481d-88a4-1ebbf6a9602e.gif (image/gif)	chlorpheniramine H1 antihistamine propylamine derivative 10X > potent than pheniramine + > - longer acting than pheniramine t 1/2 = 12-15 h
Image: 309de43e-9492-4306-ad0b-4460ef7af3fe (image/png)	Dexchloropheniramine H1 antihistamine propylamine derivative dextropheniramine
Image: 20f2ceba-2e25-492e-926e-05cc4f591b51 (image/png)	bromopheninramine H1 antihistamine propylamine derivative 10X > potent than pheniramine + > - longer acting than chlorpheniramine t 1/2 = 25h
Image: 02edcae0-fbfa-44c9-a768-35eb50da48c8 (image/png)	Dexbromopheniramine H1 antihistamine propylamine derivative
Image: 83c5a123-4e79-441d-99c1-41ae391d98f6.PNG (image/PNG)	E-pyrrobutamine (pyronil) H1 antihistamine propylamine unsaturated pheniramine potent (E (165X) > Z) t1/2 = 12h --> long acting
Image: 9be4a873-95dc-4c03-98a1-4f7540e5b68e.PNG (image/PNG)	triprolidine H1 antihistamine propylamine unsaturated pheniramine potent (E (100X) > Z) t1/2 = 12h --> long acting
Image: 734e7239-b396-4c46-ba7f-670c7a386cd7.PNG (image/PNG)	demethindine H1 antihistamine propylamine unsaturated pheniramine potent (- > +)
Image: 1f7a3f80-9142-49ff-8988-fbcb626336f7.PNG (image/PNG)	phenindamine H1 antihistamine propylamine unsaturated pheniramine moderately potent cause CNS stimulation, insomnia
Image: 23d0339c-c96a-43a8-8257-dbe713dc0ead (image/png)	Promethazine H1 antihistamine tricyclic phenothiazine moderately potent antiemetic, antianxiety pronounced sedation potentiate analgesics long DOA drowsiness
Image: b72af392-f5f1-4dff-94e1-aea162e07c4c (image/jpg)	pyrathiazine H1 antihistamine tricyclic phenothiazine moderately potent antiemetic, antianxiety pronounced sedation potentiate analgesics long DOA drowsiness
Image: 4b541398-1548-45aa-b4c8-4c10d8b5750e (image/jpg)	trimeprazine H1 antihistamine tricyclic phenothiazine less antihistaminic, more neuroleptic activity (spacer 3 C) moderately potent antiemetic, antianxiety pronounced sedation potentiate analgesics long DOA drowsiness
Image: 54004c6f-4b89-4805-ac4e-dae1f492a665 (image/jpg)	methdiazine H1 antihistamine tricyclic phenothiazine less antihistaminic, more neuroleptic activity (spacer 3 C) moderately potent antiemetic, antianxiety pronounced sedation potentiate analgesics long DOA drowsiness
Image: c2aa8173-e21d-4921-ab6d-834cc5de0320.PNG (image/PNG)	pimethixene H1 antihistamine tricyclic thioxanthene derivative orally active
Image: f6b086a8-3392-4cf2-892d-808d343f122c.PNG (image/PNG)	methixene H1 antihistamine tricyclic moderately potent anticholinergic usefull in parkinson
Image: cb6e869b-a844-48ad-aacd-0bd550666e87.PNG (image/PNG)	cyproheptadine H1 antihistamine tricyclic anticholinergic antiserotonergic appetite stimulating effect for anorexia nervosa
Image: 3ebdb647-4366-46a3-acfb-9219b175306b.PNG (image/PNG)	azatadine H1 antihistamine tricyclic aza isostere potent long acting anticholinergic
Image: bd13ecbf-0fa0-450b-9d6c-757b06ab3880.PNG (image/PNG)	ketotifen H1 antihistamine tricyclic potent mast cell stabilizer topically (for seasonal allergic conjunctivitis) nasal spray (for allergic rhinitis)
Image: 5dd0c764-11fd-46de-9229-c23abc64c1e4 (image/jpg)	terfenadine H1 antihistamine 2nd generation less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects QT prolongation, torsade de pointes give fexofenadine
Image: 24715b50-2469-4eba-ae1e-3671863fa90e (image/jpg)	fexofenadine H1 antihistamine 2nd generation less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects active safer
Image: cf763d58-bca6-4357-8814-e9fd46f035e3 (image/png)	ebastine H1 antihistamine 2nd generation potent long acting less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects from terfenadine
Image: 7fb01836-71ac-42b9-b10b-0f498130ce67.PNG (image/PNG)	cetirizine H1 antihistamine 2nd generation metabolite of hydroxyzine levo (30X): levocetirizine > dextro less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects
Image: 223ea0eb-ea5a-4710-b6d2-1b0ad59ed41c.gif (image/gif)	loratadine H1 antihistamine 2nd generation metabolite of azatadine long acting tricyclic less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects forms desloratadine
Image: a206bd68-ae43-49c4-b122-cfb8f52204ff.PNG (image/PNG)	acrivastine H1 antihistamine 2nd generation metabolite of tripolidine lacks CNS effects less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects
Image: 53d8cbce-e771-4c03-9b7c-e821c220dddd.PNG (image/PNG)	mizolastine H1 antihistamine 2nd generation long acting less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects metabolized into inactive
Image: 898dbd92-00cb-45f3-9ee9-ff32cc785c06.PNG (image/PNG)	astemizole H1 antihistamine 2nd generation less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects
Image: 73f46564-71a0-4d46-aa64-6823ead51f88 (image/jpg)	carebastine H1 antihistamine 2nd generation less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects
Image: 0a8cc66a-6bee-4892-bbd7-4b2dd59e48fc (image/png)	desloratadine H1 antihistamine 2nd generation less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects
Image: 9bd5a825-7895-42da-81c7-4400b528f294.PNG (image/PNG)	burimamide H2 antihistamine 1st generation antiulcer thiurea derivative poor oral bioavailability low potency for GERD treatment
Image: 2c123a15-7eb3-44d6-aad7-594605bdb3de.PNG (image/PNG)	metiamide H2 antihistamine 1st generation antiulcer thiourea derivative orally active potent agranulocytosis for GERD treatment
Image: 26d2a913-fc2e-45ad-9279-a22fdca0bc1f.PNG (image/PNG)	cimetidine H2 antihistamine 1st generation antiulcer cyanoguanidine derivative orally active potent antiandrogenic effect, CYP inhibition metabolized to S-oxide (inactive) for GERD treatment
Image: cb406da0-973e-4ecf-8997-74f4b048ef69 (image/png)	Ranitidine H2 antihistamine 2nd generation antiulcer orally active (30-80% bioavailable) potent (4-10X more than cimetidine) weaker inhibitor of CYP enzymes no antiandrogenic effects renal elimination metabolized: N-desmethyl, S-oxide, N-oxide for GERD treatment
Image: 5be76631-0a79-4e44-9e63-0f9baff62959 (image/png)	nizatidine H2 antihistamine 2nd generation antiulcer orally active (75-100% bioavailable) potent (5-18X more than cimetidine) not an inhibitor of CYP enzymes no antiandrogenic effects renal elimination metabolized: N-desmethyl, S-oxide, N-oxide for GERD treatment
Image: a0677d85-1978-4dca-80f6-f93a303a0cdc.PNG (image/PNG)	famotidine H2 antihistamine 2nd generation antiulcer orally active (40-45% bioavailable) more potent not an inhibitor of CYP enzymes no antiandrogenic effects for GERD treatment
Image: 5ba9a78f-63c8-4abe-b01a-e30135d5a6b6 (image/png)	omeprazole antiulcer proton pump inhibitor (H+/K+ ATPase) 2-pyridylmethylsulfinylbenzimidazole derivative irreversible inhibitors for activation: acidic media--> sulfenic acid, sulfenamide (active, bind irreversibly by covalent bond) metabolites: methyl hydroxylation, O-demethylation (CYP2C19) sulfoxidation (CYP3A4) clearance: R(+) --> rapidly, metabolized by CYP2C19 S(-)--> esomeprazole, metabolized by CYP3A4
Image: 7d6b292c-3762-46b0-9303-c70e9677abdd (image/png)	Esomeprazol antiulcer proton pump inhibitor(H+/K+ ATPase) 2-pyridylmethylsulfinylbenzimidazole derivative irreversible inhibitors S (-) omeprazole metabolized by CYP3A4
Image: a4a683dd-ae69-47f1-ac83-f194145cf8bb (image/jpg)	tenatoprazole antiulcer proton pump inhibitor(H+/K+ ATPase) irreversible inhibitors imidazopyridine derivative
Image: 7d78a35d-ae81-48c9-b6b6-8113ae2f9906 (image/png)	lansoprazole antiulcer proton pump inhibitor(H+/K+ ATPase) 2-pyridylmethylsulfinylbenzimidazole derivative irreversible inhibitors
Image: a679e2ad-f124-4ad1-9753-b87f9717f8cb (image/png)	Rabeprazole antiulcer proton pump inhibitor(H+/K+ ATPase) 2-pyridylmethylsulfinylbenzimidazole derivative irreversible inhibitors thio ether
Image: 8b0ee80a-0838-4738-9c1a-e4144526121b.gif (image/gif)	pantoprazole antiulcer proton pump inhibitor(H+/K+ ATPase) 2-pyridylmethylsulfinylbenzimidazole derivative irreversible inhibitors
Image: a7d4af74-79a6-4ffd-96c8-3753c305a8b5.PNG (image/PNG)	misoprostol antiulcer semisynthetic prostaglandin E1 derivative ester prodrug abotifacient agent (causes abortion) de-esterification --> active metabolite (not by 16-hydroxydehydrogenase) abuse potential
Image: e69612f8-11bc-4b8b-82de-67976263d670.PNG (image/PNG)	prostaglandin E1 antiulcer maintain mucosal integrity, protect gastric wall
Image: 88cd4881-0972-41f0-bc0b-a08857a8d56f (image/png)	sucralfate antiulcer aluminium hydroxide complex of octasulfate ester of sucrose small amount absorbed systematically synthesize: prostaglandin, bicarbonate, epidermal, fibroblast growth factors decrease absorption of: H2 antihistamine, quinolone antibiotic, phenytoin, warfarin
Image: 9e768691-ec45-4cfe-a86e-c546fb595fb8.PNG (image/PNG)	carbenoxolone antiulcer steroid like from licorice mineralocorticoid activity (SE) inhibit PG inactivation
Image: ce7a380c-9355-4d43-9b96-65ffe5c3c3f9.PNG (image/PNG)	pirenzepine antiulcer anticholinergic selective M1 receptor antagonist decrease GI acid secretion, intestinal mobility
Image: 19a715f7-6813-4d75-8002-81dc76fa827d.PNG (image/PNG)	telenzepine antiulcer anticholinergic selective M1 receptor antagonist decrease GI acid secretion, intestinal mobility
Image: 737d88cf-1477-4ae3-be26-485702f79663.PNG (image/PNG)	steroid backbone
Image: 32bcad20-9e70-4a8e-b6d1-adc2d391cca9.PNG (image/PNG)	steroid template
Image: 54a0e879-9fd0-44da-a9a6-4cc6a0970c77.PNG (image/PNG)	phenantrene
Image: b76f9e48-fa7f-444b-b29c-80ea89cdbbfd.PNG (image/PNG)	cholestane template
Image: b875f6e0-693f-4229-ba79-05e5f08f5c0c.PNG (image/PNG)	5-beta-cholestane cis isomer
Image: dd0b00ef-1b7c-4da6-a071-f241c3afd5ca.PNG (image/PNG)	5-beta-cholestane cis isomer
Image: 83849228-9e4f-4489-b70f-360ebf69b852.PNG (image/PNG)	5-alpha-cholestane trans isomer
Image: b860c493-a886-43b6-bc94-b97f595c32e0.PNG (image/PNG)	5-alpha-cholestane trans isomer precursor of cholesterol
Image: 13786b70-a73c-48fb-9b71-1238267eedee.PNG (image/PNG)	5-alpha-pregnane steroid precursor of progesterone and hydrocortisone (cortisol)
Image: a89c7a83-537a-40f5-86df-a71a4b75f3a1.PNG (image/PNG)	5-alpha-androstane steroid precursor of testosterone and dehydroepiandrosterone
Image: 0c317421-f887-46b5-91ed-934dd5d8be9c.PNG (image/PNG)	5-alpha-estrane steroid precursor of estradiol
Image: e6393ea8-be6c-4a30-81f9-33b7fb7cac41.PNG (image/PNG)	cholesterol steroid adrenocorticoid cholest-5-en-3-beta-ol formed from acetyl CoA and acetoacetyl CoA forms pregnenolone, bile acids (glycocholic acid, taurocholic acid)
Image: f8ec39b7-5edd-4c46-a9c4-1e2e7f542a5c.PNG (image/PNG)	progesterone steroid adrenocorticoid pregn-4-ene-3,20-dione
Image: efbe3583-4de2-4a78-97c7-c2b3fe4925ea.PNG (image/PNG)	hydrocortisone (cortisol) steroid adrenocorticoid 11-beta-17-alpha-21-trihydroxy-pregn-4-ene-3,20-dione short acting active metabolized to cortisone, inactive metabolites orally: completely absorbed (>95% bioavailability) t1/2 = 1-2h IM (acetate): slowly absorbed longer duration of action intrarectally: poorly absorbed
Image: 4e5e2ec1-3adf-4da3-b638-8c5867ebbada.PNG (image/PNG)	testosterone steroid 17-beta-hydroxyandrost-4-ene-3-one
Image: 0eb6df5f-0b65-4ae0-8a0f-8c0e77f42980.PNG (image/PNG)	dehydroepiandrosterone DHEA steroid
Image: 9d3c1863-b4e9-453e-ba37-a82986b2a861.PNG (image/PNG)	17-beta-estradiol steroid 1,3,5(10)-estratien-3,17-beta-diol
Image: 96b49cf6-585f-4146-ac8f-12bcffe7117e (image/png)	cortisone steroid 17-alpha-21-dihydroxypregn-4-ene-3,11,20-trione natural short acting t1/2= 1-1.5h active orally/ IM (21-acetate): slowly absorbed, longer duration SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
Image: 45631d50-55e9-4fe7-b95a-89c476dc0ae7 (image/png)	estrone steroid 1,3,5(10)-estratrien-3-ol-17-one
Image: a7cb4a28-7c6b-43ae-8172-95eb93731e48.PNG (image/PNG)	pregnenolone steroid adrenocorticoid metabolite of oxidation of cholesterol active
Image: 4430240f-87e6-4d24-8dbd-a5b3e829bc3d.PNG (image/PNG)	aldosterone steroid adrenocorticoid from cholesterol active
Image: d5112901-9649-4c81-9196-8549755a7522.PNG (image/PNG)	11-epicortisol steroid first analogue
Image: 90b3dc8e-227f-4c13-b76c-ebc1af926175.gif (image/gif)	hydrocortisone acetate steroid mineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
Image: 6cdfb7c3-e5e0-44bb-bfdd-ecbb7b2e9eb1.gif (image/gif)	hydrocortisone cypionate steroid 21-(3-cyclopentylpropionate) ester water insoluble orally mineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
Image: 55b28521-7c81-4ac8-bf00-6e90c1f6d251 (image/png)	hydrocortisone butyrate steroid 17-alpha-butyrate-ester topically mineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
Image: a1d6117e-38da-4ba8-90c6-cbcf5f3f596f (image/png)	hydrocortisone buteprate steroid 17-alpha-butyrate, 21-propionate ester mineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
Image: 24524517-6c92-4de7-bd41-22f991fcba8b.gif (image/gif)	hydrocortisone valerate steroid 17-alpha-valerate ester topically mineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
Image: 10af95ca-b467-43c1-ac39-ecf75dfbf911.gif (image/gif)	hydrocortisone sodium succinate steroid 21-sodium succinate ester extremely water soluble IV/IM slowly and incompletely hydrolyzed t1/2= 30minmineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
Image: 5e3942ca-83b1-4949-bd60-4a309302a8fa (image/png)	hydrocortisone sodium phosphate steroid 21-sodium phosphate ester extremely water soluble IV/IM completely and rapidly metabolized t1/2= 10min mineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
Image: c9ad002b-8bc7-4c9a-a8ce-e26b1e38f1ba (image/png)	fludrocortisone steroid orally active high glucocorticoid activity increase stability of 11-beta-OH if Br at 9: increase 11X glucocorticoid, increase 300-800X mineralocorticoid for adrenocortical insufficiency: addison's disease
Image: 05bd7842-24a4-46f5-a9a8-4e4d6791c519.gif (image/gif)	fludrocortisone acetate steroid orally active high glucocorticoid activity increase stability of 11-beta-OH if Br at 9: increase 11X glucocorticoid, increase 300-800X mineralocorticoid for adrenocortical insufficiency: addison's disease
Image: 4153bf44-2b33-444c-9b2f-0a2f146df0c7.PNG (image/PNG)	prednisolone steroid delta 1-hydrocortisone longer acting more glucocorticoid act (3-4) than mineralocorticoid act. (1) 4-5X more potent less salt retention
Image: 7de17111-9fb3-4631-8f1c-a67e7a4aec1e.PNG (image/PNG)	6-beta-hydroxyprednisolone steroid metabolite of prednisolone active
Image: cb929d7b-4889-4bfe-96dd-943b9db6278f.PNG (image/PNG)	16-alpha-hydroxyprednisolone steroid metabolite of prednisolone active
Image: 3e4e5c82-9ecf-4e2a-88ba-b133b237ee7b.PNG (image/PNG)	20-hydroxyprednisolone steroid metabolite of prednisolone inactive
Image: 0c66cf9b-53d5-4ec1-a2ff-12de0b3c92e5.gif (image/gif)	Prednisolone acetate steroid delta corticosteroid
Image: e15b40a3-25a6-4c57-a8ba-e69968ede4be.gif (image/gif)	prednisolone t-butylacetate steroid delta corticosteroid
Image: d2f0f5da-180c-4135-b22b-5142fe448834.gif (image/gif)	prednisolone sodium phosphate steroid delta corticosteroid
Image: 661a45dc-8244-458f-8b73-9b26c8f89589 (image/png)	methylprednisolone steroid methyl corticoid 6-alpha-methyl analogue of prednisolone potent glucocorticoid negligible mineralocorticoid
Image: 2090f744-a1a7-42aa-9646-723df7f44ff8.gif (image/gif)	methylprednisolone 21-acetate steroid methyl corticoid
Image: e8df0047-3601-4476-a724-d38a2b55b17f.gif (image/gif)	methylprednisolone sodium succinate steroid methyl corticoid
Image: 8d570c59-85ef-45e8-9cee-8aaa3c925750.PNG (image/PNG)	triamcinolone steroid 9-alpha fluro-16-alpha OH prednisolone more potent less water retention SE: anorexia, weight loss, nausea, dizziness, muscle weakness
Image: a14dcd31-a55d-42cb-9746-40441647357a (image/png)	Dexamethasone steroid 9-alpha fluro-16-alpha methyl higher stability of 20-keto group 5X more potent as anti-inflammatory (compared to prednisolone, hydrocortisone) SE: excessive appetite, weight gain, abdominal distention
Image: 99a806a6-c618-4bb2-aab0-8cd1301228ea.gif (image/gif)	Dexamethasone 21-acetate steroid
Image: 564e1aa9-2d6e-493b-91f4-d60606f5384d (image/jpg)	dexamethasone sodium phosphate steroid
Image: bffa8cc5-9fcb-463c-851a-0e421205e5f9.PNG (image/PNG)	betamethasone steroid 9-alpha fluro-16-beta CH3 no advantage same potency, same SE as dexamethasone
Image: 3bed3e90-405a-4ca9-928c-fe20fa0981d5.PNG (image/PNG)	flurandrenolide steroid topical glucocorticoid high activity high lipid solubility (acetonides) potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: a50589e9-712f-42c3-b745-4d6d543a3097 (image/jpg)	fluocinolone acetonide steroid topical glucocorticoid high activity high lipid solubility (acetonides) potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: 6857b880-38b2-499f-927d-650357c87c2b.gif (image/gif)	fluocinonide steroid topical glucocorticoid high activity high lipid solubility (acetonides) potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: 75e2c9d7-2141-4a0c-ac6a-1dee72374bde.PNG (image/PNG)	halcinonide steroid topical glucocorticoid high activity high lipid solubility (acetonides) potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: 3b055a56-d1b5-48b2-a9d5-54dc6f79829b.PNG (image/PNG)	desonide steroid topical glucocorticoid high lipid solubility (acetonides) potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: 3ac31da8-5ef5-4399-b4bf-c036f5312b2d.PNG (image/PNG)	amcinonide steroid topical glucocorticoid high activity high lipid solubility (acetonides) potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: 6b40f0a5-ad28-4db3-a352-f885cebf8c77.PNG (image/PNG)	clobetasol propionate steroid topical glucocorticoid high activity high lipid solubility very potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: 260f8de7-81bd-487d-907d-fea9f7bc9542.PNG (image/PNG)	alcometasone steroid topical glucocorticoid low potent (for chronic use) metabolized in liver excreted in bile or urine
Image: 9d8c277c-6140-4cdf-80e5-221f6858e519 (image/png)	flumethasone steroid topical glucocorticoid high activity potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: 78cc7962-535a-4f3e-9c0c-2bc602abd80c.gif (image/gif)	diflorasone diacetate steroid topical glucocorticoid high activity high lipid solubility very potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: 099267dd-fee3-45f0-958d-628a06ba3213.PNG (image/PNG)	desoximetasone steroid topical glucocorticoid high activity high lipid solubility potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: 33875e9c-eb6e-4033-9a1d-109733c7c230 (image/png)	beclomethasone steroid topical glucocorticoid high lipid solubility potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: 4654df39-2125-4bb8-a775-37e0d11de112 (image/png)	beclomethasone dipropionate steroid topical glucocorticoid high lipid solubility very potent local/topical antiinflammatory effect (for short duration) 5000X more potent than hydrocortisone 500X more potent than betamethasone 5X more potent than fluocinolone acetonide or triamcinolone acetonide metabolized in liver excreted in bile or urine
Image: 4ff2f758-3bf4-4ee2-b4b0-5dd441551393.PNG (image/PNG)	halobetasol propionate steroid topical glucocorticoid high lipid solubility very potent local/topical antiinflammatory effect (for short duration) 6% systemically absorbed metabolized in liver excreted in bile or urine
Image: 340a5077-c62b-4f73-9065-3f61f4c1450e.PNG (image/PNG)	diflucortolone pivalate steroid topical glucocorticoid high activity high lipid solubility potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: 8b09627d-8d2e-4cde-aea5-7d51bc6f3151.PNG (image/PNG)	prednicarbate steroid topical glucocorticoid low potency (for chronic use) metabolized in liver excreted in bile or urine
Image: 68366228-4376-4e9d-934b-5d9c85de1954.PNG (image/PNG)	fluorometholone acetate steroid topical glucocorticoid high activity high lipid solubility potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
Image: 67e9d06d-72ed-4c3b-9b33-76db454173ed.PNG (image/PNG)	triamcinolone acetonide steriod inhaled/intranasal corticosteroid high activity high potency
Image: 0d8ed311-e174-472d-a538-40aef9b4bd5f.PNG (image/PNG)	flunisolide steriod inhaled/intranasal corticosteroid high activity high potency
Image: 13dd6d23-4a60-4ed9-ae01-b33cbde7c839.PNG (image/PNG)	fluticasone propionate steriod inhaled/intranasal corticosteroid high activity high potency
Image: ad3707a7-3572-4136-9d2b-c1a07be9fd36.PNG (image/PNG)	budesonide steriod inhaled/intranasal corticosteroid high potency
Image: 85a061e0-dc04-4def-b670-70a10cb77d9e.PNG (image/PNG)	mometasone furoate steriod inhaled/intranasal corticosteroid
Image: d7159d48-8c17-4248-b4b7-96a05f647eb0.PNG (image/PNG)	androstenedione steroid precursor of testosterone and estradiol
Image: cfab99d0-1d63-4893-9cd6-97bd8c5eee3b.PNG (image/PNG)	estrone steroid precursor of estradiol
Image: 6841cd58-01c4-4047-9708-30c6b7908651.PNG (image/PNG)	testosterone steroid precursor of estradiol
Image: b72c9639-05d0-434f-b3ce-3bd2867d577c.PNG (image/PNG)	estradiol steroid estra-1,3,5(10)-triene-3,17beta-diol most potent
Image: b670da33-c040-4da5-a581-7165073c00ab.PNG (image/PNG)	estriol steroid metabolite of estradiol least active least potent
Image: 375a035f-26ba-4f46-a99b-3710a6fdfa3a.PNG (image/PNG)	estradiol steroid estrogen derivative
Image: abf83efa-2dd4-4bc1-b4bd-74d73cf52722.PNG (image/PNG)	estriol steroid estrogen derivative
Image: 1eb2ff3e-6d08-4d73-8caf-eb9ef1bb5834.PNG (image/PNG)	estrone steroid estrogen derivative
Image: 05661240-c77e-4b89-85e0-d387c3416d11 (image/png)	estradiol 3-benzoate steroid estrogen derivative prodrug IM
Image: cac6d13e-ea80-432d-977c-ed2c7f1f2e91 (image/png)	estradiol 17-valerate steroid estrogen derivative prodrug IM
Image: 03e89572-bfcd-495f-8992-d1f879ab9d4c.gif (image/gif)	estradiol 17-cypionate steroid estrogen derivative prodrug IM
Image: 8d89e410-ff04-4fc7-a4a1-8a9b4689cb97.PNG (image/PNG)	ethinyl estradiol steroid estrogen derivative orally active similar potency to estradiol (injection) more potent (15-20X) than estradiol (orally)
Image: 14c9dc47-9eb4-4135-8db7-57cb854bb5e5.PNG (image/PNG)	mestranol ethinyl estradiol 3-methylether steroid estrogen derivative prodrug oral contraceptive metabolized to ethinyl estradiol
Image: e632cdb9-1c2f-41c6-82fb-e9347bf3c2cc (image/png)	quinestrol steroid estrogen derivative 3-cyclopentyl ether of ethinyl estradiol prodrug most orally active long acting hydrolyzed by dealkylation lipid soluble (stored in body fat), slowly released
Image: 7ff2c658-1717-4986-99e3-4a73870b49ac.PNG (image/PNG)	sodium estrone sulfate steroid conjugated estrogen hydrolyzed to estrone
Image: 54769326-7257-47a4-87ac-af6e49f66b89.PNG (image/PNG)	equilin sodium sulfate steroid conjugated estrogen low activity (unsaturation in ring B)
Image: 4c9dd00c-d373-4e55-9746-ba47796de5f8.PNG (image/PNG)	sodium equilenin sulfate steroid conjugated estrogen low activity (unsaturated ring B)
Image: 45dd5b1e-aec6-4d9e-9cc0-faf4f8fffa38 (image/jpg)	piperazine estrone sulfate steroid conjugates estrogen salt
Image: 11529132-848a-4a9a-bce7-b5fb5b3f5d51.PNG (image/PNG)	diethylstilbestrol non steroidal estrogen orally active slowly metabolized long term use in pregnancy: increase risk of breast cancer diphosphate form used for: prostate cancer
Image: c584f7f0-35ef-45e2-9b94-ff4a8152215e.PNG (image/PNG)	dienestrol nonsteroidal estrogen
Image: 492cafbb-ff7c-4764-99e3-39e593bbb2ee.PNG (image/PNG)	benzestrol non steroidal estrogen no double bonds
Image: dbd7ef5b-7384-4832-9424-fc2e7d00df6f.PNG (image/PNG)	hexestrol non steroidal estrogen no double bonds trans better
Image: d8f63cf4-898f-4674-aefd-3dd4373ae9a0.PNG (image/PNG)	coumestrol phytoestrogen natural plant substance from legumes
Image: a3a26e5e-d282-4f73-a177-97277de7480d.PNG (image/PNG)	genistein phytoestrogen natural plant substance from soybean and clover example of flavonoids
Image: abdc4f1b-7d02-48e3-bcf3-7b9bf852ddc0.PNG (image/PNG)	daidzein phytoestrogen natural plant substance from soybean example of flavonoids
Image: 6f67d7fe-0842-47dc-84b1-657f49d2820b.PNG (image/PNG)	tamoxifen estrogen antagonist antiestrogen orally active Z isomer SERM (selective estrogen receptor modifier) estrogen antagonist in breast (for estrogen dependent breast cancer) estrogen agonist in uterus and bones metabolized by CYP3A4, 2D6
Image: 96d952fa-1afa-44dc-8fdd-1c72cea5cb52.PNG (image/PNG)	N-demethyltamoxifen metabolite of tamoxifen by 3A4 active
Image: 8097ffd1-6659-4217-af5e-131cc8f1f8da.PNG (image/PNG)	4-hydroxytamoxifen metabolite of tamoxifen by 2D6 more active than tamoxifen
Image: f5eba091-900d-4e5c-9ea4-69dbd2be629a.PNG (image/PNG)	toremifene antiestrogen triphenylethylene chlorotamoxifen metabolized by CYP3A4, deamination-hydroxylation in liver (caution if liver disease) SE: hot flashes, nausea, platelet reduction, endometrial cancer
Image: cf43a8ce-6539-45d3-a004-9dcb5e7ebe01.PNG (image/PNG)	N-demethyltoremifene metabolite of toremifene by CYP3A4 active
Image: 73f61505-712a-40b9-8e84-412807aece45.PNG (image/PNG)	ospemifene metabolite of toremifene by deamination-hydroxylation active
Image: 0aaeab34-ed20-40e6-81dc-d31fe6d4bfad.PNG (image/PNG)	enclomiphene antiestrogen E isomer stimulate ovulation in women desiring pregnancy
Image: 74e3d30b-ee3e-4c4d-b7a6-df6779e4ada0.PNG (image/PNG)	zuclomiphene antiestrogen Z isomer stimulate ovulation in women desiring pregnancy
Image: 402ce52b-7695-442f-a2a9-b4a521ec5f67.PNG (image/PNG)	raloxifene antiestrogen benzothiophene SERM estrogen antagonist: on endometrium and breast tissues estrogen agonist: on bones and cardiovascular to treat and prevent osteoporosis in postmenopausal extensive first pass metabolism (to active) --> low oral bioavailability
Image: 9d6c508b-6c36-47ca-b492-27f94a7bbe27.PNG (image/PNG)	fulvestrant pure antiestrogen hydrophobic side chain poor oral bioavailability IM prevent growth of tamoxifen resistant breast cancer metabolized to active and less active for pregnant women taking anticoagulant/ have thrombocytopenia SE: GI symptoms, headache, hot flashes
Image: 79ae2eca-4890-425f-b927-38e3c1e45536.PNG (image/PNG)	exemestane aromatase (estrogen biosynthesis) inhibitor steroidal derivative (type 1 inhibitors) 10-beta-propynylestr-4-ene-3,17-dione for breast cancer decrease estrogen: 85-95% in 2-3 days no CYP effect metabolite: 17-hydroxy metabolite --> active, higher affinity to receptor
Image: 8a5ad65d-d5eb-43f5-b2b3-deaca8a78b6b.PNG (image/PNG)	formestane aromatase (estrogen biosynthesis) inhibitor irreversible inhibitor steroidal derivative (type 1 inhibitors) 4-hydroxyandrostenedione for breast cancer given parenterally (no oral activity)
Image: 2268c46d-cae9-4e30-b9a3-8f46c46e1bf2.PNG (image/PNG)	anastrozole aromatase (estrogen biosynthesis) inhibitor triazole (type 2 inhibitors) selective first line in advanced breast cancer in postmenopausal women decrease estrogen: 80% in 2 weeks long t1/2 = 50h (once daily) metabolized to inactive inhibit CYP 1A2, 2C9, 3A4
Image: 259032b6-2aa3-4507-a84a-c7305dff8b43.PNG (image/PNG)	letrozole aromatase (estrogen biosynthesis) inhibitor triazole (type 2 inhibitors) selective decrease estrogen: 75-90% in 2-3 days metabolized to inactive
Image: bc71a445-5f16-45fe-80e6-14ba22d470e4.PNG (image/PNG)	progesterone steroid female sex hormone t1/2= 5-10min renally excreted: glucuronide (miscarriage index), sulfate conjugate (5-beta-pregnanediol)
Image: 06b2d9d1-d5a4-46c0-bf73-976460a51003.PNG (image/PNG)	20-alpha/beta-hydroxyprogesterone steroid metabolite of progesterone by reduction of 20 ketone
Image: 9e67e018-8337-49a1-a4b2-c9abdbf1addf.PNG (image/PNG)	5-beta-pregnanediol steroid metabolite of progesterone by reduction of 4,5 double bond
Image: 23eed06d-1f51-4f15-b53b-ab217186f8dc.PNG (image/PNG)	6-alpha-hydroxyprogesterone steroid metabolite of progesterone by hydroxylation at C6
Image: 617f0a0d-6c23-4dc4-b6d7-6402fcb68ff3.PNG (image/PNG)	ethisterone steroid testosterone derivative 17-alpha alkyl derivative orally active
Image: 7a9b8720-556f-4c99-b0dd-db5f588a3795.PNG (image/PNG)	dimethisterone steroid testosterone derivative 17-alpha alkyl derivative orally active
Image: 2f379503-2e4b-446e-a264-b1181aedfd6e.PNG (image/PNG)	19-norprogesterone steroid testosterone derivative
Image: f2bb4906-1a94-4aab-bc52-06d26b2327bd.PNG (image/PNG)	norethindrone steroid 19-nortestosterone derivative potent (10x > norethynodrel) orally active
Image: af96dcd8-2709-47dc-8c11-982a7a41194e.PNG (image/PNG)	norethindrone acetate steroid 19-nortestosterone derivative orally administered/ transdermally metabolized by deacetylation (rapidly,completely) in GI and liver--> norethindrone
Image: 53569b85-71f4-4179-881f-2705a5a95248.PNG (image/PNG)	norethynodrel steroid 19-nortestosterone derivative potent orally active
Image: c2807e82-1305-469f-a2c8-ba76b1b2da7b.PNG (image/PNG)	ethynodiol diacetate steroid 19-nortestosterone derivative prodrug
Image: 47fc1196-ed5a-4f40-aced-6f9c8916f84e.PNG (image/PNG)	norgestrel steroid 19-nortestosterone derivative orally active (oral contraceptives)
Image: bd1aca43-73b8-4c2d-8628-29107229d560.PNG (image/PNG)	levonorgestrel steroid 19-nortestosterone derivative active isomer orally active (OC) weak androgenic activity no glucocorticoid, mineralocorticoid act.
Image: a1977de6-204f-48a8-a5d0-0ee8742822fd.PNG (image/PNG)	norgestimate steroid levonorgestrel derivative prodrug metabolized to 2 active metabolites (norelgestromine (in intestine, liver), levonorgestrel (in liver)) in mono, triphasic OC few androgenic SE
Image: 69679115-04fa-435b-8a2b-0339686fa66c.PNG (image/PNG)	desogestrel steroid levonorgestrel derivative prodrug metabolized rapidly to active metabolite (etenogestrel) in intestinal mucosa and first pass oral bioavailability: 84% in mono and triphasic OC few androgenic SE
Image: 693b9fa1-04b9-490a-bba2-6e94ea3b04c0.PNG (image/PNG)	etonogestrel steroid levonorgestrel derivative active metabolite of desogestrel
Image: 73dc0e33-b039-4977-a61f-c8c4775d6264.PNG (image/PNG)	gestodene steroid levonorgestrel derivative oral bioavailability: 100% (not prodrug) excellent progesterone receptor binding affinity in mono and triphasic OC--> small increase in triglyceride/total cholest levels
Image: 1bc49576-7e22-4ece-a4cd-6643c76bf2cc.PNG (image/PNG)	17-alpha-acetoxyprogesterone steroid progesterone derivative limited activity orally undergoes 6-alpha hydroxylation
Image: d2c6af3f-b030-4ef9-b3aa-1a74611329a5.PNG (image/PNG)	medroxyprogesterone acetate steroid progesterone derivative 25X active > ethisterone orally administered completely, rapidly metabolized by first pass (deacetylation) --> medroxyprogesterone (metabolized like progesterone) metabolites excreted in urine (glucuronide conjugates)
Image: 81e73d28-acbf-413d-93e8-a776a7827529.PNG (image/PNG)	megestrol acetate steroid progesterone derivative from medroxyprogesterone acetate progestin activity for treatment of breast, endometrial cancer/ hormone dependent carcinoma
Image: 1e5835a6-ac8f-4f5e-87a2-a785ead90ade.PNG (image/PNG)	dienogest steroid 19-nortestosterone estrane skeleton, C17 cyanomethyl group, C9,10 double bond in OC preparation
Image: ff800c38-0ed6-4b66-b895-37510ef3f2fc.PNG (image/PNG)	drospirenone steroid 19-norprogesterone from spironolactone antimineralocorticoid activity (5x affinity to receptor > aldosterone) antiandrogenic action progestin activity (10% of levonorgestrel)
Image: a65b2f30-f9df-44c1-93dc-779f647fc9fe.PNG (image/PNG)	elcometrine steroid 19-norprogesterone derivative potent SQ (100x more potent than orally), intravaginally, transdermally antiestrogenic action no androgenic/antiandrogenic activity
Image: 696e5d9e-2a94-41de-8c4e-444eb69cae87.PNG (image/PNG)	nomegestrol acetate steroid 19-norprogesterone derivative better selectivity, more potent (than medroxyprogesterone acetate) in OC preparations no glucocorticoid/antimineralocorticoid/ androgenic act has significant antiandrogenic action
Image: 5f99cc43-a743-4a96-bff5-e1183be576c3.PNG (image/PNG)	trimegestone steroid 19-norprogesterone derivative most potent high affinity to progesterone receptor weak affinity to mineralocorticoid receptor no glucocorticoid/androgenic/ antiandrogenic act metabolic hydroxylation --> metabolites with progestogenic action
Image: cc359682-1201-4a8b-be35-feae7cb0bc4e.PNG (image/PNG)	mifepristone steroid progesterone antagonist orally active rapidly absorbed bioavailability: 70% antiglucocorticoid act metabolism: mono,di-dealkylation, 17-propyl hydroxylation-->inactive metabolite fecal elimination (83%) for hormone dependent breast cancer
Image: 2889699b-2719-4cce-9b48-2dbab2da6c80.PNG (image/PNG)	onapristone steroid progesterone antagonist less antiglucocorticoid act for hormone dependent breast cancer
Image: 020bd892-3ddb-471e-aa47-c40feb4d64a1.PNG (image/PNG)	telapristone acetate steroid progesterone antagonist for hormone dependent breast cancer
Image: 6c9840a3-5c35-40aa-899e-2e2c2aa8b05e.PNG (image/PNG)	ulipristal acetate steroid progesterone antagonist very high affinity to progesterone receptor (selective) reduce effect of hormonal contraceptive delay/inhibit ovulation alter endometrium to prevent uterine implantation metabolism: mono --> active, di-dealkylation
Image: 1866e845-1789-4da8-9999-6262a2adf52f.PNG (image/PNG)	testosterone steroid male sex hormone from androstenedione do nitrogen retention: increasing the rate of protein synthesis and muscle mass, decrease in the rate of protein catabolism have androgenic activity (development of male reproductive tissues) / anabolic activity (cell growth,protein synthesis..)
Image: 084a1973-af71-43b3-a44d-a6e8ce57f0c3.PNG (image/PNG)	5-alpha-dihydrotestosterone steroid metabolite of testosterone most potent endogenous androgen
Image: 966996e3-df6b-4087-9b99-e54d77d94bb5.PNG (image/PNG)	17-alpha-methyltestosterone steroid testosterone derivative DOA: 24h
Image: 3c371833-eaf5-4007-afe1-00694a9d090e.PNG (image/PNG)	oxymesterone steroid testosterone derivative
Image: 44bc58d8-105c-46ef-8ee0-eb4b7942ce1a.PNG (image/PNG)	methandrostenolone steroid testosterone derivative
Image: b08e6ac6-93ec-43e3-88a9-7a70c4bb39b9.PNG (image/PNG)	fluoxymesterone steroid testosterone derivative DOA: 24h
Image: 6f3f3a2b-5eca-4e52-a16d-96af4f8aa9f9 (image/jpg)	testosterone 17-beta-propionate steroid testosterone derivative DOA: 1-2w
Image: 60c1a147-bf66-4a99-ae14-ed59451b3544 (image/jpg)	testosterone 17-beta-enanthate steroid testosterone derivative depot ester DOA: 2-4 w
Image: 82f11a32-3c7b-4c74-b049-fe889f47d36b.gif (image/gif)	testosterone 17-beta-undecanoate steroid testosterone derivative DOA: 10h
Image: f1154fc8-c589-400a-a8e9-916dd909a6ca.gif (image/gif)	testosterone 17-beta-cyclopentylpropionate (cypionate) steroid testosterone derivative depot ester DOA: 2-4 w
Image: dc00a697-fdfe-40dc-a7b5-207c84a5a21c.PNG (image/PNG)	oxandrolone steroid 17-alkylated derivative 2-oxasteroid analogue with lactone moiety 3x anabolic act (>17-methyltestosterone) slight androgenic act
Image: c5915614-f262-4c23-943a-36e2958163db.PNG (image/PNG)	stanozolol steroid 17-alkylated derivative pyrazole derivative anabolic act
Image: ef7c3825-639d-49d8-9255-d89b40c940d9.PNG (image/PNG)	testolactone steroid 17-alkylated derivative 18-oxasteroid anabolic act little androgenic act irreversible aromatase inhibitor
Image: 9767ceb9-d1ee-4b1d-b2b2-6cdcda30cead.PNG (image/PNG)	norethandrolone steroid 19-norandrogens better anabolic act
Image: 8406ae44-2085-4d6c-a57b-7c1e97b6a911.gif (image/gif)	nandrolone decanoate steroid 19-norandrogen IM slow hydrolysis
Image: cb629dd6-6043-4475-8280-08f54df20902 (image/jpg)	nandrolone phenylpropionate steroid 19-norandrogen IM slow hydrolysis
Image: dba2280c-37a1-485a-99de-a41767fb17d8.PNG (image/PNG)	methenolone acetate steroid potent anabolic act no alkyl on C17 orally/injection
Image: e88d1b02-e6dd-4842-95a9-b025b2a982b1.PNG (image/PNG)	oxymetholone steroid 17-alkylated derivative anabolic act
Image: e36e454e-bec5-45fb-a723-806311bac461.PNG (image/PNG)	chlortestosterone acetate steroid anabolic act
Image: 970009d4-300e-4302-a1f1-9328a4781232.PNG (image/PNG)	ethylestrenol steroid 17-alkylated derivative anabolic act
Image: 427c0107-3226-42a4-a439-6e039d6fc2d6.PNG (image/PNG)	desoxymethyltestosterone steroid illegal anabolic agent difficult to trace
Image: 4bb94d5a-bc36-4d3f-9d61-9178d569c20b.PNG (image/PNG)	tetrahydrogestrinone steroid illegal anabolic agent difficult to trace to build up cattle
Image: aea65ce5-1f4a-4a15-a4cd-741446e1a2fb.PNG (image/PNG)	gestrinone steroid illegal anabolic agent difficult to trace
Image: d7888362-aa67-4d66-b00d-ce841237e4ab.PNG (image/PNG)	trenbolone steroid illegal anabolic agent difficult to trace
Image: 9f88c0d6-98cb-4812-9467-fe6f88fef1e1.PNG (image/PNG)	3-trifluoromethyl-4-nitroaniline antiandrogens precursor
Image: 528d4a3b-b68d-4a92-86cc-a754d64f762f.PNG (image/PNG)	flutamide antiandrogens nonsteroidal synthetic Competitive inhibitors (to testosterone and DHT) of androgen receptor given 3x/day
Image: c53e0478-cd22-4b09-a3b0-a5e256088643.PNG (image/PNG)	bicalutamide antiandrogens nonsteroidal synthetic orally active Competitive inhibitors (to testosterone and DHT) of androgen receptor metabolized: hydroxyl metabolite -->active (in liver) less hepatotoxicity SE: vasomotor flushing, gynecomastia, decreases libido, decreased potency
Image: af81c2ff-c10d-43a8-ab2f-52278f5886ed (image/png)	nilutamide antiandrogens nonsteroidal synthetic Competitive inhibitors (to testosterone and DHT) of androgen receptor SE: vasomotor flushing, gynecomastia, decreases libido, decreased potency, hepatotoxicity
Image: c07d0266-b59c-4fb8-8df9-56a1fad8092c.PNG (image/PNG)	hydroxyflutamide metabolite of flutamide more potent antiandrogen
Image: 83830118-f35a-4938-9436-79398419333e.PNG (image/PNG)	finasteride steroid 5-alpha reductase inhibitor (tightly) irreversible competitive inhibition relatively selective for type II potent slow t1/2=30d 1mg suppress DHT (70% in plasma, 85-90% in prostate in 24h) metabolism: CYP3A4 (liver) elimination: renal (40%), fecal
Image: 6e6a7b92-835c-4337-8c19-0195fd57775e.PNG (image/PNG)	dutasteride steroid 5-alpha reductase inhibitor (tightly) irreversible competitive inhibition for 2 types orally active more potent 0.5mg/day for 2w suppress DHT (90% in plasma) to treat BPH metabolism: CYP3A4 (liver), parahydroxy metabolite --> active elimination: renal, fecal (40%)

Next up

Description

Resource summary

Similar

	Created by lola_smily about 9 years ago