med chem 2 exam 2

lola_smily
Flashcards by lola_smily, updated 11 months ago
lola_smily
Created by lola_smily almost 5 years ago
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Flashcards on med chem 2 exam 2, created by lola_smily on 03/17/2015.

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Question Answer
a2e6e1dd-0ca8-445c-8161-1a57b98deeb2.PNG (image/PNG) histidine
bb78cbe0-a869-4549-8cc7-1bbbe3b0f55e.PNG (image/PNG) histamine
99f62484-4e40-4616-a0d5-734b11701dbe.PNG (image/PNG) khellin antihistaminic inhibit histamine release chromone moiety from ammi visnaga bronchodilatory effect (don't reverse bronchoconstriction)
9d7277f2-c534-4f5a-91d5-bc1fcef137b5.PNG (image/PNG) cromolyn sodium antihistaminic inhibit histamine and SRS-A release (locally) bis-chromone no bronchodilatory and antihistaminic effects strictly prophylactic low oral bioavailability (poor absorption) by inhalation (for allergic rhinitis) topically: eye drops (for allergic conjunctivitis) 5-30 min before attack if chronic use: tolerance
b1a36ce4-21d0-4ab4-9ae6-52cdb6247ec6.PNG (image/PNG) nedocromil sodium antihistaminic inhibit histamine release chromone derivative by inhalation: aerosol (for prophylaxis of asthma) ophthalmic solution (for seasonal, perennial allergic conjunctivitis)
56457feb-e2db-40b4-8fb3-40fc1c795ed8.PNG (image/PNG) lodoxamide antihistaminic mast cell stabilizer (inhibit immediate hypersensitivity reaction) topically: eye (for conjunctivitis)
3f5fa4e8-f802-4bd2-b060-c0fe09237721.PNG (image/PNG) pemirolast potassium antihistaminic inhibit histamine release pyrimidone
21226924-382d-4609-9922-649f63ebfdab.PNG (image/PNG) phenbenzamine H1 antihistaminic ethylenediamine SE: sedation, drowsiness, impair mental activity
93893dc5-4a26-42a5-a2be-928e0a5edf5f.png (image/png) Tripelennamine H1 antihistaminic ethylenediamine SE: sedation, drowsiness, impair mental activity
5e6997d1-c0ae-46b5-9602-bd972ea317bf.png (image/png) pyrilamine H1 antihistaminic ethylenediamine local anesthetic effect (tongue numbness) SE: sedation, drowsiness, impair mental activity
96889815-631d-4616-9cef-f694583c4da5.png (image/png) thonzylamine H1 antihistaminic ethylenediamine SE: sedation, drowsiness, impair mental activity
3f16a2b0-5777-4944-8e82-3a870467a547.png (image/png) methapyrilene H1 antihistaminic ethylenediamine SE: sedation, drowsiness, impair mental activity
949dcf60-4b20-4762-9900-8891a5242393.PNG (image/PNG) antazoline H1 antihistaminic ethylenediamine SE: sedation, drowsiness, impair mental activity
6d017d6a-bd2e-499b-a566-8bcd70b9910f.png (image/png) Diphenhydramine H1 antihistamine ethanolamine ether antihistaminic, antiemetic, antitussive, marked sedation, anticholinergic, antidyskinetic SE: sedation, drowsiness
4c99039a-1960-447e-ba56-7d1f6cc8f43e.jpg (image/jpg) bromodiphenhydramine H1 antihistamine ethanolamine ether more lipid soluble, more potent antihistaminic, antiemetic, antitussive, marked sedation, anticholinergic, antidyskinetic SE: sedation, drowsiness
66e9bd3b-36ac-4c5a-a708-db24d6ca663d.jpg (image/jpg) chlorodiphenhydramine H1 antihistamine ethanolamine ether more lipid soluble, more potent antihistaminic, antiemetic, antitussive, marked sedation, anticholinergic, antidyskinetic SE: sedation, drowsiness
15527e07-a100-4f39-a680-07d41d75713a.png (image/png) Doxylamine H1 antihistamine ethanolamine ether most potent CNS depressant hypnotic agent no abuse potential SE: sedation, drowsiness
701273e1-71b3-4b6f-9da1-983dcf3b8068.png (image/png) Carbinoxamine H1 antihistamine ethanolamine ether potent - (rotoxamine)> + (available as racemic mixture) SE: sedation, drowsiness
3493acad-e5bb-492b-b84d-b378e00efc31.PNG (image/PNG) clemastine H1 antihistamine aminoalkyl ether RR more potent long DOA less anticholinergic less sedation
d41e4e30-7c94-40c6-a929-e74fbef6398e.PNG (image/PNG) clemastine H1 antihistamine aminoalkyl ether RR more potent long DOA less anticholinergic less sedation
c92ea610-0359-491e-b843-193ba8b2bf5c.PNG (image/PNG) setastine H1 antihistaminic aminoalkyl ether
71229c9d-f8bb-48c5-8415-aabf3b220ba7.png (image/png) cyclizine H1 antihistamine piperazine derivative for nausea, vomiting (from motion sickness and radiation sickness) cyclizine lactate IM injection moderately potent prolonged DOA anticholinergic effects
7d2acce9-62fc-41f2-9f9a-c19528586f7f.png (image/png) Chlorcyclizine H1 antihistamine piperazine derivative antiallergic (for urticaria and hay fever) more lipophilic moderately potent prolonged DOA anticholinergic effect
52b8e96a-5575-46e7-9ba2-ec881d15da6f.png (image/png) Hydroxyzine H1 antihistaminic piperazine derivative marked sedation antiemetic, antiallergic (for pruritis) at high dose: for anxiety and emotional stress moderately potent prolonged DOA anticholinergic effects
f1443488-72ef-41a2-8441-b7b798b04ba5.png (image/png) Cetirizine H1 antihistamine piperazine derivative 2nd generation ionized --> less absorbed antinauseant moderately potent prolonged DOA anticholinergic effects
c416301f-c511-4f53-98ca-021dc9901ad5.jpeg (image/jpeg) Meclizine H1 antihistamine piperazine derivative for nausea (from motion sickness and radiation sickness) moderately potent prolonged DOA anticholinergic effects
d77d9eaf-31a2-4758-bd97-a486b58e8dea.png (image/png) buclizine H1 antihistamine piperazine derivative for nausea (from motion sickness and radiation sickness) moderately potent prolonged DOA anticholinergic effects
e4d7fdac-cd7b-4fe0-8dcd-fe00208ae3d9.jpg (image/jpg) oxatomide H1 antihistamine piperazine derivative antimuscarinic, mast cell stabilizer (less release of histamine) moderately potent prolonged DOA anticholinergic effects
7f3514a1-c985-481d-88a4-1ebbf6a9602e.gif (image/gif) chlorpheniramine H1 antihistamine propylamine derivative 10X > potent than pheniramine + > - longer acting than pheniramine t 1/2 = 12-15 h
309de43e-9492-4306-ad0b-4460ef7af3fe.png (image/png) Dexchloropheniramine H1 antihistamine propylamine derivative dextropheniramine
20f2ceba-2e25-492e-926e-05cc4f591b51.png (image/png) bromopheninramine H1 antihistamine propylamine derivative 10X > potent than pheniramine + > - longer acting than chlorpheniramine t 1/2 = 25h
02edcae0-fbfa-44c9-a768-35eb50da48c8.png (image/png) Dexbromopheniramine H1 antihistamine propylamine derivative
83c5a123-4e79-441d-99c1-41ae391d98f6.PNG (image/PNG) E-pyrrobutamine (pyronil) H1 antihistamine propylamine unsaturated pheniramine potent (E (165X) > Z) t1/2 = 12h --> long acting
9be4a873-95dc-4c03-98a1-4f7540e5b68e.PNG (image/PNG) triprolidine H1 antihistamine propylamine unsaturated pheniramine potent (E (100X) > Z) t1/2 = 12h --> long acting
734e7239-b396-4c46-ba7f-670c7a386cd7.PNG (image/PNG) demethindine H1 antihistamine propylamine unsaturated pheniramine potent (- > +)
1f7a3f80-9142-49ff-8988-fbcb626336f7.PNG (image/PNG) phenindamine H1 antihistamine propylamine unsaturated pheniramine moderately potent cause CNS stimulation, insomnia
23d0339c-c96a-43a8-8257-dbe713dc0ead.png (image/png) Promethazine H1 antihistamine tricyclic phenothiazine moderately potent antiemetic, antianxiety pronounced sedation potentiate analgesics long DOA drowsiness
b72af392-f5f1-4dff-94e1-aea162e07c4c.jpg (image/jpg) pyrathiazine H1 antihistamine tricyclic phenothiazine moderately potent antiemetic, antianxiety pronounced sedation potentiate analgesics long DOA drowsiness
4b541398-1548-45aa-b4c8-4c10d8b5750e.jpg (image/jpg) trimeprazine H1 antihistamine tricyclic phenothiazine less antihistaminic, more neuroleptic activity (spacer 3 C) moderately potent antiemetic, antianxiety pronounced sedation potentiate analgesics long DOA drowsiness
54004c6f-4b89-4805-ac4e-dae1f492a665.jpg (image/jpg) methdiazine H1 antihistamine tricyclic phenothiazine less antihistaminic, more neuroleptic activity (spacer 3 C) moderately potent antiemetic, antianxiety pronounced sedation potentiate analgesics long DOA drowsiness
c2aa8173-e21d-4921-ab6d-834cc5de0320.PNG (image/PNG) pimethixene H1 antihistamine tricyclic thioxanthene derivative orally active
f6b086a8-3392-4cf2-892d-808d343f122c.PNG (image/PNG) methixene H1 antihistamine tricyclic moderately potent anticholinergic usefull in parkinson
cb6e869b-a844-48ad-aacd-0bd550666e87.PNG (image/PNG) cyproheptadine H1 antihistamine tricyclic anticholinergic antiserotonergic appetite stimulating effect for anorexia nervosa
3ebdb647-4366-46a3-acfb-9219b175306b.PNG (image/PNG) azatadine H1 antihistamine tricyclic aza isostere potent long acting anticholinergic
bd13ecbf-0fa0-450b-9d6c-757b06ab3880.PNG (image/PNG) ketotifen H1 antihistamine tricyclic potent mast cell stabilizer topically (for seasonal allergic conjunctivitis) nasal spray (for allergic rhinitis)
5dd0c764-11fd-46de-9229-c23abc64c1e4.jpg (image/jpg) terfenadine H1 antihistamine 2nd generation less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects QT prolongation, torsade de pointes give fexofenadine
24715b50-2469-4eba-ae1e-3671863fa90e.jpg (image/jpg) fexofenadine H1 antihistamine 2nd generation less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects active safer
cf763d58-bca6-4357-8814-e9fd46f035e3.png (image/png) ebastine H1 antihistamine 2nd generation potent long acting less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects from terfenadine
7fb01836-71ac-42b9-b10b-0f498130ce67.PNG (image/PNG) cetirizine H1 antihistamine 2nd generation metabolite of hydroxyzine levo (30X): levocetirizine > dextro less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects
223ea0eb-ea5a-4710-b6d2-1b0ad59ed41c.gif (image/gif) loratadine H1 antihistamine 2nd generation metabolite of azatadine long acting tricyclic less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects forms desloratadine
a206bd68-ae43-49c4-b122-cfb8f52204ff.PNG (image/PNG) acrivastine H1 antihistamine 2nd generation metabolite of tripolidine lacks CNS effects less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects
53d8cbce-e771-4c03-9b7c-e821c220dddd.PNG (image/PNG) mizolastine H1 antihistamine 2nd generation long acting less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects metabolized into inactive
898dbd92-00cb-45f3-9ee9-ff32cc785c06.PNG (image/PNG) astemizole H1 antihistamine 2nd generation less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects
73f46564-71a0-4d46-aa64-6823ead51f88.jpg (image/jpg) carebastine H1 antihistamine 2nd generation less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects
0a8cc66a-6bee-4892-bbd7-4b2dd59e48fc.png (image/png) desloratadine H1 antihistamine 2nd generation less or no: anticholinergic, sedation low affinity to adrenergic and serotonergic effects
9bd5a825-7895-42da-81c7-4400b528f294.PNG (image/PNG) burimamide H2 antihistamine 1st generation antiulcer thiurea derivative poor oral bioavailability low potency for GERD treatment
2c123a15-7eb3-44d6-aad7-594605bdb3de.PNG (image/PNG) metiamide H2 antihistamine 1st generation antiulcer thiourea derivative orally active potent agranulocytosis for GERD treatment
26d2a913-fc2e-45ad-9279-a22fdca0bc1f.PNG (image/PNG) cimetidine H2 antihistamine 1st generation antiulcer cyanoguanidine derivative orally active potent antiandrogenic effect, CYP inhibition metabolized to S-oxide (inactive) for GERD treatment
cb406da0-973e-4ecf-8997-74f4b048ef69.png (image/png) Ranitidine H2 antihistamine 2nd generation antiulcer orally active (30-80% bioavailable) potent (4-10X more than cimetidine) weaker inhibitor of CYP enzymes no antiandrogenic effects renal elimination metabolized: N-desmethyl, S-oxide, N-oxide for GERD treatment
5be76631-0a79-4e44-9e63-0f9baff62959.png (image/png) nizatidine H2 antihistamine 2nd generation antiulcer orally active (75-100% bioavailable) potent (5-18X more than cimetidine) not an inhibitor of CYP enzymes no antiandrogenic effects renal elimination metabolized: N-desmethyl, S-oxide, N-oxide for GERD treatment
a0677d85-1978-4dca-80f6-f93a303a0cdc.PNG (image/PNG) famotidine H2 antihistamine 2nd generation antiulcer orally active (40-45% bioavailable) more potent not an inhibitor of CYP enzymes no antiandrogenic effects for GERD treatment
5ba9a78f-63c8-4abe-b01a-e30135d5a6b6.png (image/png) omeprazole antiulcer proton pump inhibitor (H+/K+ ATPase) 2-pyridylmethylsulfinylbenzimidazole derivative irreversible inhibitors for activation: acidic media--> sulfenic acid, sulfenamide (active, bind irreversibly by covalent bond) metabolites: methyl hydroxylation, O-demethylation (CYP2C19) sulfoxidation (CYP3A4) clearance: R(+) --> rapidly, metabolized by CYP2C19 S(-)--> esomeprazole, metabolized by CYP3A4
7d6b292c-3762-46b0-9303-c70e9677abdd.png (image/png) Esomeprazol antiulcer proton pump inhibitor(H+/K+ ATPase) 2-pyridylmethylsulfinylbenzimidazole derivative irreversible inhibitors S (-) omeprazole metabolized by CYP3A4
a4a683dd-ae69-47f1-ac83-f194145cf8bb.jpg (image/jpg) tenatoprazole antiulcer proton pump inhibitor(H+/K+ ATPase) irreversible inhibitors imidazopyridine derivative
7d78a35d-ae81-48c9-b6b6-8113ae2f9906.png (image/png) lansoprazole antiulcer proton pump inhibitor(H+/K+ ATPase) 2-pyridylmethylsulfinylbenzimidazole derivative irreversible inhibitors
a679e2ad-f124-4ad1-9753-b87f9717f8cb.png (image/png) Rabeprazole antiulcer proton pump inhibitor(H+/K+ ATPase) 2-pyridylmethylsulfinylbenzimidazole derivative irreversible inhibitors thio ether
8b0ee80a-0838-4738-9c1a-e4144526121b.gif (image/gif) pantoprazole antiulcer proton pump inhibitor(H+/K+ ATPase) 2-pyridylmethylsulfinylbenzimidazole derivative irreversible inhibitors
a7d4af74-79a6-4ffd-96c8-3753c305a8b5.PNG (image/PNG) misoprostol antiulcer semisynthetic prostaglandin E1 derivative ester prodrug abotifacient agent (causes abortion) de-esterification --> active metabolite (not by 16-hydroxydehydrogenase) abuse potential
e69612f8-11bc-4b8b-82de-67976263d670.PNG (image/PNG) prostaglandin E1 antiulcer maintain mucosal integrity, protect gastric wall
88cd4881-0972-41f0-bc0b-a08857a8d56f.png (image/png) sucralfate antiulcer aluminium hydroxide complex of octasulfate ester of sucrose small amount absorbed systematically synthesize: prostaglandin, bicarbonate, epidermal, fibroblast growth factors decrease absorption of: H2 antihistamine, quinolone antibiotic, phenytoin, warfarin
9e768691-ec45-4cfe-a86e-c546fb595fb8.PNG (image/PNG) carbenoxolone antiulcer steroid like from licorice mineralocorticoid activity (SE) inhibit PG inactivation
ce7a380c-9355-4d43-9b96-65ffe5c3c3f9.PNG (image/PNG) pirenzepine antiulcer anticholinergic selective M1 receptor antagonist decrease GI acid secretion, intestinal mobility
19a715f7-6813-4d75-8002-81dc76fa827d.PNG (image/PNG) telenzepine antiulcer anticholinergic selective M1 receptor antagonist decrease GI acid secretion, intestinal mobility
737d88cf-1477-4ae3-be26-485702f79663.PNG (image/PNG) steroid backbone
32bcad20-9e70-4a8e-b6d1-adc2d391cca9.PNG (image/PNG) steroid template
54a0e879-9fd0-44da-a9a6-4cc6a0970c77.PNG (image/PNG) phenantrene
b76f9e48-fa7f-444b-b29c-80ea89cdbbfd.PNG (image/PNG) cholestane template
b875f6e0-693f-4229-ba79-05e5f08f5c0c.PNG (image/PNG) 5-beta-cholestane cis isomer
dd0b00ef-1b7c-4da6-a071-f241c3afd5ca.PNG (image/PNG) 5-beta-cholestane cis isomer
83849228-9e4f-4489-b70f-360ebf69b852.PNG (image/PNG) 5-alpha-cholestane trans isomer
b860c493-a886-43b6-bc94-b97f595c32e0.PNG (image/PNG) 5-alpha-cholestane trans isomer precursor of cholesterol
13786b70-a73c-48fb-9b71-1238267eedee.PNG (image/PNG) 5-alpha-pregnane steroid precursor of progesterone and hydrocortisone (cortisol)
a89c7a83-537a-40f5-86df-a71a4b75f3a1.PNG (image/PNG) 5-alpha-androstane steroid precursor of testosterone and dehydroepiandrosterone
0c317421-f887-46b5-91ed-934dd5d8be9c.PNG (image/PNG) 5-alpha-estrane steroid precursor of estradiol
e6393ea8-be6c-4a30-81f9-33b7fb7cac41.PNG (image/PNG) cholesterol steroid adrenocorticoid cholest-5-en-3-beta-ol formed from acetyl CoA and acetoacetyl CoA forms pregnenolone, bile acids (glycocholic acid, taurocholic acid)
f8ec39b7-5edd-4c46-a9c4-1e2e7f542a5c.PNG (image/PNG) progesterone steroid adrenocorticoid pregn-4-ene-3,20-dione
efbe3583-4de2-4a78-97c7-c2b3fe4925ea.PNG (image/PNG) hydrocortisone (cortisol) steroid adrenocorticoid 11-beta-17-alpha-21-trihydroxy-pregn-4-ene-3,20-dione short acting active metabolized to cortisone, inactive metabolites orally: completely absorbed (>95% bioavailability) t1/2 = 1-2h IM (acetate): slowly absorbed longer duration of action intrarectally: poorly absorbed
4e5e2ec1-3adf-4da3-b638-8c5867ebbada.PNG (image/PNG) testosterone steroid 17-beta-hydroxyandrost-4-ene-3-one
0eb6df5f-0b65-4ae0-8a0f-8c0e77f42980.PNG (image/PNG) dehydroepiandrosterone DHEA steroid
9d3c1863-b4e9-453e-ba37-a82986b2a861.PNG (image/PNG) 17-beta-estradiol steroid 1,3,5(10)-estratien-3,17-beta-diol
96b49cf6-585f-4146-ac8f-12bcffe7117e.png (image/png) cortisone steroid 17-alpha-21-dihydroxypregn-4-ene-3,11,20-trione natural short acting t1/2= 1-1.5h active orally/ IM (21-acetate): slowly absorbed, longer duration SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
45631d50-55e9-4fe7-b95a-89c476dc0ae7.png (image/png) estrone steroid 1,3,5(10)-estratrien-3-ol-17-one
a7cb4a28-7c6b-43ae-8172-95eb93731e48.PNG (image/PNG) pregnenolone steroid adrenocorticoid metabolite of oxidation of cholesterol active
4430240f-87e6-4d24-8dbd-a5b3e829bc3d.PNG (image/PNG) aldosterone steroid adrenocorticoid from cholesterol active
d5112901-9649-4c81-9196-8549755a7522.PNG (image/PNG) 11-epicortisol steroid first analogue
90b3dc8e-227f-4c13-b76c-ebc1af926175.gif (image/gif) hydrocortisone acetate steroid mineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
6cdfb7c3-e5e0-44bb-bfdd-ecbb7b2e9eb1.gif (image/gif) hydrocortisone cypionate steroid 21-(3-cyclopentylpropionate) ester water insoluble orally mineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
55b28521-7c81-4ac8-bf00-6e90c1f6d251.png (image/png) hydrocortisone butyrate steroid 17-alpha-butyrate-ester topically mineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
a1d6117e-38da-4ba8-90c6-cbcf5f3f596f.png (image/png) hydrocortisone buteprate steroid 17-alpha-butyrate, 21-propionate ester mineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
24524517-6c92-4de7-bd41-22f991fcba8b.gif (image/gif) hydrocortisone valerate steroid 17-alpha-valerate ester topically mineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
10af95ca-b467-43c1-ac39-ecf75dfbf911.gif (image/gif) hydrocortisone sodium succinate steroid 21-sodium succinate ester extremely water soluble IV/IM slowly and incompletely hydrolyzed t1/2= 30minmineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
5e3942ca-83b1-4949-bd60-4a309302a8fa.png (image/png) hydrocortisone sodium phosphate steroid 21-sodium phosphate ester extremely water soluble IV/IM completely and rapidly metabolized t1/2= 10min mineralocorticoid and glucocorticoid act. for replacement therapy (adrenocortical deficiency) for rheumatoid arthritis --> caus abnormal metabolic function SE: Na/H2O retention, K excretion, increase gastric acid secretion, gluconeogenesis, increase nitrogen excretion
c9ad002b-8bc7-4c9a-a8ce-e26b1e38f1ba.png (image/png) fludrocortisone steroid orally active high glucocorticoid activity increase stability of 11-beta-OH if Br at 9: increase 11X glucocorticoid, increase 300-800X mineralocorticoid for adrenocortical insufficiency: addison's disease
05bd7842-24a4-46f5-a9a8-4e4d6791c519.gif (image/gif) fludrocortisone acetate steroid orally active high glucocorticoid activity increase stability of 11-beta-OH if Br at 9: increase 11X glucocorticoid, increase 300-800X mineralocorticoid for adrenocortical insufficiency: addison's disease
4153bf44-2b33-444c-9b2f-0a2f146df0c7.PNG (image/PNG) prednisolone steroid delta 1-hydrocortisone longer acting more glucocorticoid act (3-4) than mineralocorticoid act. (1) 4-5X more potent less salt retention
7de17111-9fb3-4631-8f1c-a67e7a4aec1e.PNG (image/PNG) 6-beta-hydroxyprednisolone steroid metabolite of prednisolone active
cb929d7b-4889-4bfe-96dd-943b9db6278f.PNG (image/PNG) 16-alpha-hydroxyprednisolone steroid metabolite of prednisolone active
3e4e5c82-9ecf-4e2a-88ba-b133b237ee7b.PNG (image/PNG) 20-hydroxyprednisolone steroid metabolite of prednisolone inactive
0c66cf9b-53d5-4ec1-a2ff-12de0b3c92e5.gif (image/gif) Prednisolone acetate steroid delta corticosteroid
e15b40a3-25a6-4c57-a8ba-e69968ede4be.gif (image/gif) prednisolone t-butylacetate steroid delta corticosteroid
d2f0f5da-180c-4135-b22b-5142fe448834.gif (image/gif) prednisolone sodium phosphate steroid delta corticosteroid
661a45dc-8244-458f-8b73-9b26c8f89589.png (image/png) methylprednisolone steroid methyl corticoid 6-alpha-methyl analogue of prednisolone potent glucocorticoid negligible mineralocorticoid
2090f744-a1a7-42aa-9646-723df7f44ff8.gif (image/gif) methylprednisolone 21-acetate steroid methyl corticoid
e8df0047-3601-4476-a724-d38a2b55b17f.gif (image/gif) methylprednisolone sodium succinate steroid methyl corticoid
8d570c59-85ef-45e8-9cee-8aaa3c925750.PNG (image/PNG) triamcinolone steroid 9-alpha fluro-16-alpha OH prednisolone more potent less water retention SE: anorexia, weight loss, nausea, dizziness, muscle weakness
a14dcd31-a55d-42cb-9746-40441647357a.png (image/png) Dexamethasone steroid 9-alpha fluro-16-alpha methyl higher stability of 20-keto group 5X more potent as anti-inflammatory (compared to prednisolone, hydrocortisone) SE: excessive appetite, weight gain, abdominal distention
99a806a6-c618-4bb2-aab0-8cd1301228ea.gif (image/gif) Dexamethasone 21-acetate steroid
564e1aa9-2d6e-493b-91f4-d60606f5384d.jpg (image/jpg) dexamethasone sodium phosphate steroid
bffa8cc5-9fcb-463c-851a-0e421205e5f9.PNG (image/PNG) betamethasone steroid 9-alpha fluro-16-beta CH3 no advantage same potency, same SE as dexamethasone
3bed3e90-405a-4ca9-928c-fe20fa0981d5.PNG (image/PNG) flurandrenolide steroid topical glucocorticoid high activity high lipid solubility (acetonides) potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
a50589e9-712f-42c3-b745-4d6d543a3097.jpg (image/jpg) fluocinolone acetonide steroid topical glucocorticoid high activity high lipid solubility (acetonides) potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
6857b880-38b2-499f-927d-650357c87c2b.gif (image/gif) fluocinonide steroid topical glucocorticoid high activity high lipid solubility (acetonides) potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
75e2c9d7-2141-4a0c-ac6a-1dee72374bde.PNG (image/PNG) halcinonide steroid topical glucocorticoid high activity high lipid solubility (acetonides) potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
3b055a56-d1b5-48b2-a9d5-54dc6f79829b.PNG (image/PNG) desonide steroid topical glucocorticoid high lipid solubility (acetonides) potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
3ac31da8-5ef5-4399-b4bf-c036f5312b2d.PNG (image/PNG) amcinonide steroid topical glucocorticoid high activity high lipid solubility (acetonides) potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
6b40f0a5-ad28-4db3-a352-f885cebf8c77.PNG (image/PNG) clobetasol propionate steroid topical glucocorticoid high activity high lipid solubility very potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
260f8de7-81bd-487d-907d-fea9f7bc9542.PNG (image/PNG) alcometasone steroid topical glucocorticoid low potent (for chronic use) metabolized in liver excreted in bile or urine
9d8c277c-6140-4cdf-80e5-221f6858e519.png (image/png) flumethasone steroid topical glucocorticoid high activity potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
78cc7962-535a-4f3e-9c0c-2bc602abd80c.gif (image/gif) diflorasone diacetate steroid topical glucocorticoid high activity high lipid solubility very potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
099267dd-fee3-45f0-958d-628a06ba3213.PNG (image/PNG) desoximetasone steroid topical glucocorticoid high activity high lipid solubility potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
33875e9c-eb6e-4033-9a1d-109733c7c230.png (image/png) beclomethasone steroid topical glucocorticoid high lipid solubility potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
4654df39-2125-4bb8-a775-37e0d11de112.png (image/png) beclomethasone dipropionate steroid topical glucocorticoid high lipid solubility very potent local/topical antiinflammatory effect (for short duration) 5000X more potent than hydrocortisone 500X more potent than betamethasone 5X more potent than fluocinolone acetonide or triamcinolone acetonide metabolized in liver excreted in bile or urine
4ff2f758-3bf4-4ee2-b4b0-5dd441551393.PNG (image/PNG) halobetasol propionate steroid topical glucocorticoid high lipid solubility very potent local/topical antiinflammatory effect (for short duration) 6% systemically absorbed metabolized in liver excreted in bile or urine
340a5077-c62b-4f73-9065-3f61f4c1450e.PNG (image/PNG) diflucortolone pivalate steroid topical glucocorticoid high activity high lipid solubility potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
8b09627d-8d2e-4cde-aea5-7d51bc6f3151.PNG (image/PNG) prednicarbate steroid topical glucocorticoid low potency (for chronic use) metabolized in liver excreted in bile or urine
68366228-4376-4e9d-934b-5d9c85de1954.PNG (image/PNG) fluorometholone acetate steroid topical glucocorticoid high activity high lipid solubility potent local/topical antiinflammatory effect (for short duration) metabolized in liver excreted in bile or urine
67e9d06d-72ed-4c3b-9b33-76db454173ed.PNG (image/PNG) triamcinolone acetonide steriod inhaled/intranasal corticosteroid high activity high potency
0d8ed311-e174-472d-a538-40aef9b4bd5f.PNG (image/PNG) flunisolide steriod inhaled/intranasal corticosteroid high activity high potency
13dd6d23-4a60-4ed9-ae01-b33cbde7c839.PNG (image/PNG) fluticasone propionate steriod inhaled/intranasal corticosteroid high activity high potency
ad3707a7-3572-4136-9d2b-c1a07be9fd36.PNG (image/PNG) budesonide steriod inhaled/intranasal corticosteroid high potency
85a061e0-dc04-4def-b670-70a10cb77d9e.PNG (image/PNG) mometasone furoate steriod inhaled/intranasal corticosteroid
d7159d48-8c17-4248-b4b7-96a05f647eb0.PNG (image/PNG) androstenedione steroid precursor of testosterone and estradiol
cfab99d0-1d63-4893-9cd6-97bd8c5eee3b.PNG (image/PNG) estrone steroid precursor of estradiol
6841cd58-01c4-4047-9708-30c6b7908651.PNG (image/PNG) testosterone steroid precursor of estradiol
b72c9639-05d0-434f-b3ce-3bd2867d577c.PNG (image/PNG) estradiol steroid estra-1,3,5(10)-triene-3,17beta-diol most potent
b670da33-c040-4da5-a581-7165073c00ab.PNG (image/PNG) estriol steroid metabolite of estradiol least active least potent
375a035f-26ba-4f46-a99b-3710a6fdfa3a.PNG (image/PNG) estradiol steroid estrogen derivative
abf83efa-2dd4-4bc1-b4bd-74d73cf52722.PNG (image/PNG) estriol steroid estrogen derivative
1eb2ff3e-6d08-4d73-8caf-eb9ef1bb5834.PNG (image/PNG) estrone steroid estrogen derivative
05661240-c77e-4b89-85e0-d387c3416d11.png (image/png) estradiol 3-benzoate steroid estrogen derivative prodrug IM
cac6d13e-ea80-432d-977c-ed2c7f1f2e91.png (image/png) estradiol 17-valerate steroid estrogen derivative prodrug IM
03e89572-bfcd-495f-8992-d1f879ab9d4c.gif (image/gif) estradiol 17-cypionate steroid estrogen derivative prodrug IM
8d89e410-ff04-4fc7-a4a1-8a9b4689cb97.PNG (image/PNG) ethinyl estradiol steroid estrogen derivative orally active similar potency to estradiol (injection) more potent (15-20X) than estradiol (orally)
14c9dc47-9eb4-4135-8db7-57cb854bb5e5.PNG (image/PNG) mestranol ethinyl estradiol 3-methylether steroid estrogen derivative prodrug oral contraceptive metabolized to ethinyl estradiol
e632cdb9-1c2f-41c6-82fb-e9347bf3c2cc.png (image/png) quinestrol steroid estrogen derivative 3-cyclopentyl ether of ethinyl estradiol prodrug most orally active long acting hydrolyzed by dealkylation lipid soluble (stored in body fat), slowly released
7ff2c658-1717-4986-99e3-4a73870b49ac.PNG (image/PNG) sodium estrone sulfate steroid conjugated estrogen hydrolyzed to estrone
54769326-7257-47a4-87ac-af6e49f66b89.PNG (image/PNG) equilin sodium sulfate steroid conjugated estrogen low activity (unsaturation in ring B)
4c9dd00c-d373-4e55-9746-ba47796de5f8.PNG (image/PNG) sodium equilenin sulfate steroid conjugated estrogen low activity (unsaturated ring B)
45dd5b1e-aec6-4d9e-9cc0-faf4f8fffa38.jpg (image/jpg) piperazine estrone sulfate steroid conjugates estrogen salt
11529132-848a-4a9a-bce7-b5fb5b3f5d51.PNG (image/PNG) diethylstilbestrol non steroidal estrogen orally active slowly metabolized long term use in pregnancy: increase risk of breast cancer diphosphate form used for: prostate cancer
c584f7f0-35ef-45e2-9b94-ff4a8152215e.PNG (image/PNG) dienestrol nonsteroidal estrogen
492cafbb-ff7c-4764-99e3-39e593bbb2ee.PNG (image/PNG) benzestrol non steroidal estrogen no double bonds
dbd7ef5b-7384-4832-9424-fc2e7d00df6f.PNG (image/PNG) hexestrol non steroidal estrogen no double bonds trans better
d8f63cf4-898f-4674-aefd-3dd4373ae9a0.PNG (image/PNG) coumestrol phytoestrogen natural plant substance from legumes
a3a26e5e-d282-4f73-a177-97277de7480d.PNG (image/PNG) genistein phytoestrogen natural plant substance from soybean and clover example of flavonoids
abdc4f1b-7d02-48e3-bcf3-7b9bf852ddc0.PNG (image/PNG) daidzein phytoestrogen natural plant substance from soybean example of flavonoids
6f67d7fe-0842-47dc-84b1-657f49d2820b.PNG (image/PNG) tamoxifen estrogen antagonist antiestrogen orally active Z isomer SERM (selective estrogen receptor modifier) estrogen antagonist in breast (for estrogen dependent breast cancer) estrogen agonist in uterus and bones metabolized by CYP3A4, 2D6
96d952fa-1afa-44dc-8fdd-1c72cea5cb52.PNG (image/PNG) N-demethyltamoxifen metabolite of tamoxifen by 3A4 active
8097ffd1-6659-4217-af5e-131cc8f1f8da.PNG (image/PNG) 4-hydroxytamoxifen metabolite of tamoxifen by 2D6 more active than tamoxifen
f5eba091-900d-4e5c-9ea4-69dbd2be629a.PNG (image/PNG) toremifene antiestrogen triphenylethylene chlorotamoxifen metabolized by CYP3A4, deamination-hydroxylation in liver (caution if liver disease) SE: hot flashes, nausea, platelet reduction, endometrial cancer
cf43a8ce-6539-45d3-a004-9dcb5e7ebe01.PNG (image/PNG) N-demethyltoremifene metabolite of toremifene by CYP3A4 active
73f61505-712a-40b9-8e84-412807aece45.PNG (image/PNG) ospemifene metabolite of toremifene by deamination-hydroxylation active
0aaeab34-ed20-40e6-81dc-d31fe6d4bfad.PNG (image/PNG) enclomiphene antiestrogen E isomer stimulate ovulation in women desiring pregnancy
74e3d30b-ee3e-4c4d-b7a6-df6779e4ada0.PNG (image/PNG) zuclomiphene antiestrogen Z isomer stimulate ovulation in women desiring pregnancy
402ce52b-7695-442f-a2a9-b4a521ec5f67.PNG (image/PNG) raloxifene antiestrogen benzothiophene SERM estrogen antagonist: on endometrium and breast tissues estrogen agonist: on bones and cardiovascular to treat and prevent osteoporosis in postmenopausal extensive first pass metabolism (to active) --> low oral bioavailability
9d6c508b-6c36-47ca-b492-27f94a7bbe27.PNG (image/PNG) fulvestrant pure antiestrogen hydrophobic side chain poor oral bioavailability IM prevent growth of tamoxifen resistant breast cancer metabolized to active and less active for pregnant women taking anticoagulant/ have thrombocytopenia SE: GI symptoms, headache, hot flashes
79ae2eca-4890-425f-b927-38e3c1e45536.PNG (image/PNG) exemestane aromatase (estrogen biosynthesis) inhibitor steroidal derivative (type 1 inhibitors) 10-beta-propynylestr-4-ene-3,17-dione for breast cancer decrease estrogen: 85-95% in 2-3 days no CYP effect metabolite: 17-hydroxy metabolite --> active, higher affinity to receptor
8a5ad65d-d5eb-43f5-b2b3-deaca8a78b6b.PNG (image/PNG) formestane aromatase (estrogen biosynthesis) inhibitor irreversible inhibitor steroidal derivative (type 1 inhibitors) 4-hydroxyandrostenedione for breast cancer given parenterally (no oral activity)
2268c46d-cae9-4e30-b9a3-8f46c46e1bf2.PNG (image/PNG) anastrozole aromatase (estrogen biosynthesis) inhibitor triazole (type 2 inhibitors) selective first line in advanced breast cancer in postmenopausal women decrease estrogen: 80% in 2 weeks long t1/2 = 50h (once daily) metabolized to inactive inhibit CYP 1A2, 2C9, 3A4
259032b6-2aa3-4507-a84a-c7305dff8b43.PNG (image/PNG) letrozole aromatase (estrogen biosynthesis) inhibitor triazole (type 2 inhibitors) selective decrease estrogen: 75-90% in 2-3 days metabolized to inactive
bc71a445-5f16-45fe-80e6-14ba22d470e4.PNG (image/PNG) progesterone steroid female sex hormone t1/2= 5-10min renally excreted: glucuronide (miscarriage index), sulfate conjugate (5-beta-pregnanediol)
06b2d9d1-d5a4-46c0-bf73-976460a51003.PNG (image/PNG) 20-alpha/beta-hydroxyprogesterone steroid metabolite of progesterone by reduction of 20 ketone
9e67e018-8337-49a1-a4b2-c9abdbf1addf.PNG (image/PNG) 5-beta-pregnanediol steroid metabolite of progesterone by reduction of 4,5 double bond
23eed06d-1f51-4f15-b53b-ab217186f8dc.PNG (image/PNG) 6-alpha-hydroxyprogesterone steroid metabolite of progesterone by hydroxylation at C6
617f0a0d-6c23-4dc4-b6d7-6402fcb68ff3.PNG (image/PNG) ethisterone steroid testosterone derivative 17-alpha alkyl derivative orally active
7a9b8720-556f-4c99-b0dd-db5f588a3795.PNG (image/PNG) dimethisterone steroid testosterone derivative 17-alpha alkyl derivative orally active
2f379503-2e4b-446e-a264-b1181aedfd6e.PNG (image/PNG) 19-norprogesterone steroid testosterone derivative
f2bb4906-1a94-4aab-bc52-06d26b2327bd.PNG (image/PNG) norethindrone steroid 19-nortestosterone derivative potent (10x > norethynodrel) orally active
af96dcd8-2709-47dc-8c11-982a7a41194e.PNG (image/PNG) norethindrone acetate steroid 19-nortestosterone derivative orally administered/ transdermally metabolized by deacetylation (rapidly,completely) in GI and liver--> norethindrone
53569b85-71f4-4179-881f-2705a5a95248.PNG (image/PNG) norethynodrel steroid 19-nortestosterone derivative potent orally active
c2807e82-1305-469f-a2c8-ba76b1b2da7b.PNG (image/PNG) ethynodiol diacetate steroid 19-nortestosterone derivative prodrug
47fc1196-ed5a-4f40-aced-6f9c8916f84e.PNG (image/PNG) norgestrel steroid 19-nortestosterone derivative orally active (oral contraceptives)
bd1aca43-73b8-4c2d-8628-29107229d560.PNG (image/PNG) levonorgestrel steroid 19-nortestosterone derivative active isomer orally active (OC) weak androgenic activity no glucocorticoid, mineralocorticoid act.
a1977de6-204f-48a8-a5d0-0ee8742822fd.PNG (image/PNG) norgestimate steroid levonorgestrel derivative prodrug metabolized to 2 active metabolites (norelgestromine (in intestine, liver), levonorgestrel (in liver)) in mono, triphasic OC few androgenic SE
69679115-04fa-435b-8a2b-0339686fa66c.PNG (image/PNG) desogestrel steroid levonorgestrel derivative prodrug metabolized rapidly to active metabolite (etenogestrel) in intestinal mucosa and first pass oral bioavailability: 84% in mono and triphasic OC few androgenic SE
693b9fa1-04b9-490a-bba2-6e94ea3b04c0.PNG (image/PNG) etonogestrel steroid levonorgestrel derivative active metabolite of desogestrel
73dc0e33-b039-4977-a61f-c8c4775d6264.PNG (image/PNG) gestodene steroid levonorgestrel derivative oral bioavailability: 100% (not prodrug) excellent progesterone receptor binding affinity in mono and triphasic OC--> small increase in triglyceride/total cholest levels
1bc49576-7e22-4ece-a4cd-6643c76bf2cc.PNG (image/PNG) 17-alpha-acetoxyprogesterone steroid progesterone derivative limited activity orally undergoes 6-alpha hydroxylation
d2c6af3f-b030-4ef9-b3aa-1a74611329a5.PNG (image/PNG) medroxyprogesterone acetate steroid progesterone derivative 25X active > ethisterone orally administered completely, rapidly metabolized by first pass (deacetylation) --> medroxyprogesterone (metabolized like progesterone) metabolites excreted in urine (glucuronide conjugates)
81e73d28-acbf-413d-93e8-a776a7827529.PNG (image/PNG) megestrol acetate steroid progesterone derivative from medroxyprogesterone acetate progestin activity for treatment of breast, endometrial cancer/ hormone dependent carcinoma
1e5835a6-ac8f-4f5e-87a2-a785ead90ade.PNG (image/PNG) dienogest steroid 19-nortestosterone estrane skeleton, C17 cyanomethyl group, C9,10 double bond in OC preparation
ff800c38-0ed6-4b66-b895-37510ef3f2fc.PNG (image/PNG) drospirenone steroid 19-norprogesterone from spironolactone antimineralocorticoid activity (5x affinity to receptor > aldosterone) antiandrogenic action progestin activity (10% of levonorgestrel)
a65b2f30-f9df-44c1-93dc-779f647fc9fe.PNG (image/PNG) elcometrine steroid 19-norprogesterone derivative potent SQ (100x more potent than orally), intravaginally, transdermally antiestrogenic action no androgenic/antiandrogenic activity
696e5d9e-2a94-41de-8c4e-444eb69cae87.PNG (image/PNG) nomegestrol acetate steroid 19-norprogesterone derivative better selectivity, more potent (than medroxyprogesterone acetate) in OC preparations no glucocorticoid/antimineralocorticoid/ androgenic act has significant antiandrogenic action
5f99cc43-a743-4a96-bff5-e1183be576c3.PNG (image/PNG) trimegestone steroid 19-norprogesterone derivative most potent high affinity to progesterone receptor weak affinity to mineralocorticoid receptor no glucocorticoid/androgenic/ antiandrogenic act metabolic hydroxylation --> metabolites with progestogenic action
cc359682-1201-4a8b-be35-feae7cb0bc4e.PNG (image/PNG) mifepristone steroid progesterone antagonist orally active rapidly absorbed bioavailability: 70% antiglucocorticoid act metabolism: mono,di-dealkylation, 17-propyl hydroxylation-->inactive metabolite fecal elimination (83%) for hormone dependent breast cancer
2889699b-2719-4cce-9b48-2dbab2da6c80.PNG (image/PNG) onapristone steroid progesterone antagonist less antiglucocorticoid act for hormone dependent breast cancer
020bd892-3ddb-471e-aa47-c40feb4d64a1.PNG (image/PNG) telapristone acetate steroid progesterone antagonist for hormone dependent breast cancer
6c9840a3-5c35-40aa-899e-2e2c2aa8b05e.PNG (image/PNG) ulipristal acetate steroid progesterone antagonist very high affinity to progesterone receptor (selective) reduce effect of hormonal contraceptive delay/inhibit ovulation alter endometrium to prevent uterine implantation metabolism: mono --> active, di-dealkylation
1866e845-1789-4da8-9999-6262a2adf52f.PNG (image/PNG) testosterone steroid male sex hormone from androstenedione do nitrogen retention: increasing the rate of protein synthesis and muscle mass, decrease in the rate of protein catabolism have androgenic activity (development of male reproductive tissues) / anabolic activity (cell growth,protein synthesis..)
084a1973-af71-43b3-a44d-a6e8ce57f0c3.PNG (image/PNG) 5-alpha-dihydrotestosterone steroid metabolite of testosterone most potent endogenous androgen
966996e3-df6b-4087-9b99-e54d77d94bb5.PNG (image/PNG) 17-alpha-methyltestosterone steroid testosterone derivative DOA: 24h
3c371833-eaf5-4007-afe1-00694a9d090e.PNG (image/PNG) oxymesterone steroid testosterone derivative
44bc58d8-105c-46ef-8ee0-eb4b7942ce1a.PNG (image/PNG) methandrostenolone steroid testosterone derivative
b08e6ac6-93ec-43e3-88a9-7a70c4bb39b9.PNG (image/PNG) fluoxymesterone steroid testosterone derivative DOA: 24h
6f3f3a2b-5eca-4e52-a16d-96af4f8aa9f9.jpg (image/jpg) testosterone 17-beta-propionate steroid testosterone derivative DOA: 1-2w
60c1a147-bf66-4a99-ae14-ed59451b3544.jpg (image/jpg) testosterone 17-beta-enanthate steroid testosterone derivative depot ester DOA: 2-4 w
82f11a32-3c7b-4c74-b049-fe889f47d36b.gif (image/gif) testosterone 17-beta-undecanoate steroid testosterone derivative DOA: 10h
f1154fc8-c589-400a-a8e9-916dd909a6ca.gif (image/gif) testosterone 17-beta-cyclopentylpropionate (cypionate) steroid testosterone derivative depot ester DOA: 2-4 w
dc00a697-fdfe-40dc-a7b5-207c84a5a21c.PNG (image/PNG) oxandrolone steroid 17-alkylated derivative 2-oxasteroid analogue with lactone moiety 3x anabolic act (>17-methyltestosterone) slight androgenic act
c5915614-f262-4c23-943a-36e2958163db.PNG (image/PNG) stanozolol steroid 17-alkylated derivative pyrazole derivative anabolic act
ef7c3825-639d-49d8-9255-d89b40c940d9.PNG (image/PNG) testolactone steroid 17-alkylated derivative 18-oxasteroid anabolic act little androgenic act irreversible aromatase inhibitor
9767ceb9-d1ee-4b1d-b2b2-6cdcda30cead.PNG (image/PNG) norethandrolone steroid 19-norandrogens better anabolic act
8406ae44-2085-4d6c-a57b-7c1e97b6a911.gif (image/gif) nandrolone decanoate steroid 19-norandrogen IM slow hydrolysis
cb629dd6-6043-4475-8280-08f54df20902.jpg (image/jpg) nandrolone phenylpropionate steroid 19-norandrogen IM slow hydrolysis
dba2280c-37a1-485a-99de-a41767fb17d8.PNG (image/PNG) methenolone acetate steroid potent anabolic act no alkyl on C17 orally/injection
e88d1b02-e6dd-4842-95a9-b025b2a982b1.PNG (image/PNG) oxymetholone steroid 17-alkylated derivative anabolic act
e36e454e-bec5-45fb-a723-806311bac461.PNG (image/PNG) chlortestosterone acetate steroid anabolic act
970009d4-300e-4302-a1f1-9328a4781232.PNG (image/PNG) ethylestrenol steroid 17-alkylated derivative anabolic act
427c0107-3226-42a4-a439-6e039d6fc2d6.PNG (image/PNG) desoxymethyltestosterone steroid illegal anabolic agent difficult to trace
4bb94d5a-bc36-4d3f-9d61-9178d569c20b.PNG (image/PNG) tetrahydrogestrinone steroid illegal anabolic agent difficult to trace to build up cattle
aea65ce5-1f4a-4a15-a4cd-741446e1a2fb.PNG (image/PNG) gestrinone steroid illegal anabolic agent difficult to trace
d7888362-aa67-4d66-b00d-ce841237e4ab.PNG (image/PNG) trenbolone steroid illegal anabolic agent difficult to trace
9f88c0d6-98cb-4812-9467-fe6f88fef1e1.PNG (image/PNG) 3-trifluoromethyl-4-nitroaniline antiandrogens precursor
528d4a3b-b68d-4a92-86cc-a754d64f762f.PNG (image/PNG) flutamide antiandrogens nonsteroidal synthetic Competitive inhibitors (to testosterone and DHT) of androgen receptor given 3x/day
c53e0478-cd22-4b09-a3b0-a5e256088643.PNG (image/PNG) bicalutamide antiandrogens nonsteroidal synthetic orally active Competitive inhibitors (to testosterone and DHT) of androgen receptor metabolized: hydroxyl metabolite -->active (in liver) less hepatotoxicity SE: vasomotor flushing, gynecomastia, decreases libido, decreased potency
af81c2ff-c10d-43a8-ab2f-52278f5886ed.png (image/png) nilutamide antiandrogens nonsteroidal synthetic Competitive inhibitors (to testosterone and DHT) of androgen receptor SE: vasomotor flushing, gynecomastia, decreases libido, decreased potency, hepatotoxicity
c07d0266-b59c-4fb8-8df9-56a1fad8092c.PNG (image/PNG) hydroxyflutamide metabolite of flutamide more potent antiandrogen
83830118-f35a-4938-9436-79398419333e.PNG (image/PNG) finasteride steroid 5-alpha reductase inhibitor (tightly) irreversible competitive inhibition relatively selective for type II potent slow t1/2=30d 1mg suppress DHT (70% in plasma, 85-90% in prostate in 24h) metabolism: CYP3A4 (liver) elimination: renal (40%), fecal
6e6a7b92-835c-4337-8c19-0195fd57775e.PNG (image/PNG) dutasteride steroid 5-alpha reductase inhibitor (tightly) irreversible competitive inhibition for 2 types orally active more potent 0.5mg/day for 2w suppress DHT (90% in plasma) to treat BPH metabolism: CYP3A4 (liver), parahydroxy metabolite --> active elimination: renal, fecal (40%)
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