Question | Answer |
ACE inhibitors | Renal damage renal dysplasia |
Alcohol | Fetal Alcohol Syndrome |
Alkylating agents | Absence of digits Cleft palate Renal agenesis |
Aminoglycosides | CN VIII toxicity |
Anticonvulsants | Cleft lip and palate |
Cocaine | Abnormal fetal development Fetal addiction Low-birth weight Placental abruption |
Diethylstilbestrol (DES) | Vaginal clear cell adenocarcinoma Other cervical, ovarian, and uterine abnormalities |
Folate antagonists | Neural tube defects myelomeningocele |
Lithium | Ebstein's anomaly atrialized right ventricle |
Maternal diabetes | Caudal regression syndrome sirenomelia renal dysplasia or aplasia imperforate anus |
Phenytoin | Cleft lip and palate Congenital heart defects |
Potassium iodide | Congenital goiter or hypothyroidism Cretinism |
Nicotine | Premature delivery Low birth weight Intrauterine growth retardation ADHD |
Tetracyclines | Discolored/stained teeth |
Thalidomide | Gastrointestinal atresia Absence or malformation of external ear Phocomelia "seal" limbs |
Valproate | Inhibits intestinal folate absorption leading to neural tube defects Cleft lip Renal defects |
Vitamin A/isotretinoin | Spontaneous abortions Cleft palate Cardiac abormalities Eye and external abnormalities |
Warfarin | Bone deformities femur, vertebral, and calcaneus show stippled appearance on X-ray Fetal hemorrhage Abortion Spasticity and seizures |
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