spleen, lymph, thymus

Hayley Pfeffer
Flashcards by Hayley Pfeffer, updated more than 1 year ago
Hayley Pfeffer
Created by Hayley Pfeffer almost 6 years ago
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Diploma/Certificado de qualificação profissional de nivel 3 3rd year pathology Flashcards on spleen, lymph, thymus, created by Hayley Pfeffer on 06/16/2015.

Resource summary

Question Answer
Whci organs does the lymphohaemmopoeitic system invovle? LNs spleen thymus MALT (GALT and bLAT) BM
Function of LNs? Filter lymph- remove foreign partcles, metastic tumor cells,recycle erythrocytes Immune responses- recognise antigen, recruite T lymphocytes, start cell proliferation + antibody synthesis
what is lymph adenopathy? enlarged LNs
what are the two causes of lymphadenopathy? 1. inflammation 2. Neoplasia
Inflammation of the LNs may be due to? reactive (hyperplastic) nodes lymphadenitis
Reactive (hyperplastic) nodes = enlarged due to being secondary to drainage from inflammation from another site. Node itself not infected
Lymphadenitis primary inflammation of the node itself often due to node itself becoming infected
Supperative lymphadenitis; cause and shwat do you see? bacteria, many neutrophils in node
Eosinophilic lymphadenitis; what do you see and what is the cause? many eosinophils in node Allergy or initial parasitic infection
How do you decide what is causing lymphadenopathy? cytology- FNA histology- biopsy
Spleenic functions? -defense against blood borne pathogens -removal of abnormal or aged RBCs -haemoatopoeisis ( major organ in fetus and neonates, can revert this function in adults if necessary) -storgae or erythrocytes and platelets
Splenomegaly enlarged spleen
4 major gross presentations of splenomegaly? 1. big bloody spleen 2. big meaty spleen 3. bloody splenic nodules 4. firmer splenic nodules
Describe the big bloody spleen? -diffuse uniform enlargement -dark red -oozes blood
What causes a big bloody spleen? congestion- less blood getting out
what is a common cause of a big bloody spleen seen PM? barbituate euthanasia
Describe the big meaty spleen Diffuse uniform enlargement often paler than normal minimal blood oozing dense
Why is the big meaty spleen dense? has more cells -neoplasia -chronic haemolytic anaemia
3 diagnoses for big meaty spleen in cats? how do you differentiate? lymphoma myeloproliferative dz MCT aspirate
Describe bloody splenic nodules non uniform enlargement nodules with bloody consistency
What may cause bloody splenic nodules? haemangiosarcoma haemangioma haematoma nodular hyperplasia
Describe firm splenic nodules non-uniform enlargement nodules with firm consistency- paler, minimal blood ooze
What can cause firm splenic nodules? neoplasia- lymphoma nodular hyperplasia
What is the prognosis of haemangioma? good benign tumor of vascular endothelium
what is a haemangiosarcoma? prognosis? poor malignant tumor of vascular endothelium
prognosis of nodular hypoplasia? good
What is a haematoma and prognosis? blood clot good
What is the function of the thymus? essential for T cell development
What happens to the thymus with age? gets smaller involutes after sexual maturity- replaced by fat and CT
What are the causes of small thymus?... a rare condition viral infections zinc deficiency severe protein deficiency congenital immunodeficiency
Thymic haemorrhage idiopathic thymic haemorrahge seen in dogs -consider rat bait as DDx
The big thymus neoplasia -lymphoma or thyoma
lymphoma malignant lympoid tumor
Thyoma Primary thymic neoplasm- malignant thymic epithelial cells
Thyoma prognosis? fair to poor
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