Histopathology - Prelims

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Introduction to Pathology, Syphilis, Trichomonas, Inflammation
MBebida
Flashcards by MBebida, updated more than 1 year ago
MBebida
Created by MBebida over 8 years ago
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Study of disease Pathology
2 divisions of pathology Anatomic Clinical
Study of morphologic aspects of disease Morbid anatomy Dissection of microscopic examination Anatomic
Considered when examining a biopsy GMMIC 1. Gross anatomical make up of sample 2. Microscopic appearance of cells 3. Molecular biology of the cells, tissues, organs and whole body 4. Immunological markers present in cells 5. Chemical signatures in the sample
Subspecialties of Anatomic Pathology D VFF CHICS 1. Dermatopathology 2. Veterinary pathology 3. Forensic pathology 4. Flow cytometry 5. Cytogenetics 6. Histopathology 7. Immunohistochemistry and FISH tech. 8. Cytopathology 9. Surgical pathology
Which subspecialty: Breast lump mastectomy Surgical pathology
Which subspecialty: Examination of cells under microscope (stained) Histopathology
Which subspecialty: Cells from body fluids, scrapings/aspirations Cytopathology
Examples of Cytopathology Cervical smear Gastric washing Sputum
Which subspecialty: Post mortem examination Forensic pathology
Post mortem examination is called what? Autopsy
Which subspecialty: Skin disorders Dermatopathology
Which subspecialty: To know origin of tumor, cancer Immunohistochemistry and FISH tech.
Behavior of a disease Prognosis
Clinical Pathology subspecialties LIHIMM 1. Lab medicine 2. Immunopathology 3. Hematology 4. Involves lab analysis of body fluids 5. Medical Chemistry 6. Microbiology
Which subspecialty: Assessment of blood and urine Chemical pathology, Medical chemistry Clinical chemistry
Which subspecialty: Study of immune system disorders Immunopathology
3 examples of immune system disorders OIA 1. Organ transplant rejections 2. Immunodeficiency 3. Allergies
Which subspecialty: Diagnosis of blood diseases Hematology
6 Roles of a histotechnologist PARASS 1. Perform proper histopathologic technique 2. Adhere to policies and procedures 3. Report problems to pathologist 4. Assist pathologist 5. Slides free of excess adhesive, dirt, paraffin 6. Submit best quality slides to pathologist
Alteration of homeostasis Change in structure/function Considered abnormal in the body Disease
State of sameness/normalcy the body strives to maintain Homeostasis
Pathologic condition of body and mind Disorder
Example of nutritional disorder Vitamin deficiency
Example of bone disorder Malformation of a joint
Group of symptoms caused by several interrelated problems Syndrome
Structural/Morphological alterations associated with a diseased state in an individual Lesion
A change which is specifically characteristic of a disease Distinct for a disease Pathognomic lesion
Example of pathognomic lesion Reed-Sternberg cells (RS cells) in Hodgkins Disease
Observed manifestations, seen by naked eye Clinical Signs
Subjective feeling of an abnormality in the body Reported by the person himself/herself Clinical Symptoms
What are 5 Predisposing factors of developing disease HAGEL 1. Heredity 2. Age 3. Gender 4. Environment 5. Lifestyle
Predisposing factor for Age: Newborns and Elderly? Newborns - IS not fully developed Elderly - IS degenerating
Predisposing factor for Gendery: Men (2) Women (3) Men - Lung CA, Gout Women - prone to Breast CA, Osteoporosis, Rheumatoid arthritis
3 Arthritis include... GOR 1. Gout 2. Osteoporosis 3. Rheumatoid arthritis
Pimple is an example of what? Papule
A papule with water is what? Vesicule
Inflammation of the big toe due to Gout Podagra
Smoking causes what? (3) CEL 1. COPD 2. Emphysema 3. Lung CA
Alcohol drinking leads to what? (1) Cirrhosis
Lack of exercise may lead to what? (1) Low backbone pain
Stress can lead to what? (1) Production of oxidants
Caused by injury from an external forc Leading cause of death in children and young adults Trauma
Protective immune response that is triggered by any type of injury/irritant Inflammation
Signs and symptoms of inflammation D CTRL Dolor (pain) Calor (heat) Tumor (swelling) Rubor (redness) Loss of function
Refers to invasion of microorganisms into tissues that can cause cell or tissue injury Infection
Overgrowth in response to some type of stimulus Hyperplasia
AKA Tumors - Swelling Neoplasms
TRUE or FALSE All tumors are neoplasms FALSE
Overconsumption or underconsumption of nutrients Nutritional Imbalance
Inadequate nutrient intake Malnutrition
Ill, thin, wasted appearance of individual Cachexia
Overconsumption of nutrients and lack of exercise Obesity
Change in tissue lining Metaplasia
2 ways the immune system protects the body 1. Inflammatory response - leukocytes play a vital role in killing foreign invaders 2. Specific Ag-Ab reaction
Type I hypersensitivity Allergens (house dust, grass, perfumes, insect bites) Allergy
Body's lymphocytes cannot identify the body's own self Ag which are harmless. Type III hypersensitivity Autoimmunity
Decrease or absence of lymphocytes Decrease in CD4 Immunodeficiency
Types of disease INIP Infectious Non-infectious Idiopathic disease Psychosomatic
Type of disease making use of pathogens (Bacteria, Fungi, Virus, Protozoa) Infectious
Non-transmissible / Non-communicable diseases Non-infectious
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