3805672
Description
Flashcards by Zainab Hassoun, updated more than 1 year ago
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Created by Zainab Hassoun
over 8 years ago
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| Question | Answer |
| What is vancomycin active against? | ONLY GRAM POSITIVE BACTERIA (aerobic and anaerobic) |
| Vancomycin is NOT clinically effective against which gram positive aerobic bacilli? | Listeria monocytogenes |
| Vancomycin is used against | prophylaxis: prosthetic implant surgery, MSSA/MRSA infections, subacute bacterial endocarditis for oral and upper respiratory procedures and for GI and gentiourinary procedures pseudomembraneous colitis staphylococcal enterocolitis |
| Is Vancomycin concentration dependent or time dependent with regards to bactericidal action? | CONCENTRATION DEPENDENT |
| Vancomycin's pharmacodynamic action depends on ___________ | AUC/MIC Extra question: what is AUC/MIC? |
| Does Vancomycin interact with PBPs? | Nah |
| What does vancomycin do to the peptidoglycan chain? | Well, vancomycin prevents interaction with transglycosylase blocking growth of the peptidoglycan chain It inhibits where the transpeptidase acts |
| Can vancomycin penetrate into the cytoplasm? What effect does this have on gram negative bacteria? | It can't penetrate into the cytoplasm, no gram negative effect! |
| Is it better to administer vancomycin orally or through I.V.? T 1/2? | Poor absorption orally and is typically administered via I.V. for SERIOUS infections T 1/2 = 6 hrs |
| Where is vancomycin excreted? | in urine!!!!!! PEEEEEEEEEEEE |
| T/F: Vancomycin can penetrate most tissues | TRUEEEEEEEEE |
| T/F: Vancomycin can readily pass into CSF Bonus Question: what is CSF? | True; CSF = cerebrospinal fluid |
| What is Red Man Syndrome? | rash and itching on face, neck, extremities, severe HYPOtension and cardiac arrest happens bc of FAST I.V. infusion which leads to a SIGNIFICANT decrease in blood pressure important!!! not an allergic reaction |
| What happens if vancomycin is administered with aminoglycosides? | you have an increased risk for renal toxicity |
| What are some side effects of taking Vancomycin? | fever, chills, phlebitis nephrotoxicity (poisonous effect on kidneys) hypotension reversible neutropenia (low count of neutrophils) tissue irritation |
| Vancomycin + Nephrotoxic drugs = ????? | RENAL TOXICITY :DDDDD |
| Anesthetics + Vancomycin = ?????? | erythema, flushing erythema: basically your skin turns red (happens bc of irritation which causes dilatation of blood capillaries) |
| Non-depolarizing muscle relaxants + Vancomycin = ??????? | NEUROMUSCULAR BLOCKADE |
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