3818609
| Question | Answer |
| HYDRALAZINE Peripheral Vasodilator Direct action on smooth muscle drug induced lupus (10% incidence in higher dose, 5% in lower) 200mg/day | |
| MINOXIDIL orally active vasodilator dilates arterioles replace hydralazine in renal failure and severe HTN 1/2 life = 4 hrs reserved for ppl who havent responded to 2 other agents and diuretics it is rogaine | |
| Fenoldopam IV only infused Dopaminergic Agent D1 receptor agonist effect on arterioles of kidneys increase in renal blood flow allows for resevoir of blood and decrease in blood volume alpha 2 receptors cause decrease in tone used in short term HTN emergencies can cause reflex tachycardia | |
| Methyldopa Mild to moderate HTN 250-500 mg BID max is 3 g/day autoimmune side effects active transport can get into cns has to undergo Amino Acid decarboxylase alpha methyl norepinephrine works like clonidine | |
| Sodium Nitroprusside Used IV Control severe HTN NO released activates cGMP cascade immediate lowering of BP no reflex tach action ceases when infusion stops metabollicaly destroyed quickly solution is light sensitive | |
| PRAZOSIN 2-3 times daily 2hr 1/2life max 40mg.day no xr formulation (more frequent use prblm in older people) orthostatic htn free from cns depressive effects | |
| TERAZOSIN Longer1/2 life (12hrs) QD dosing BPH treatment | |
| DOXAZOSIN 22 hours of effect 4-8mg slower onset elerly patient QID very hard | |
| CLONIDINE Decrease in 30-60 min 1/2 lifee of 12-16 hrs 40-60% unchanged in urine dose adjustment in renal impairment tablet and transdermal patch sustained release for 7 days Rebound HTN when withdrawn quickly | |
| GAUNFACINE rebound HTN less frequent than clonidine alpha 2 agonist central 1/2 life avg of 17 hrs (10-30hrs) older people have longer 1/2 life 50% dose in urine (lower dose in ppl with renal problems) |
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