4981829
Description
Flashcards by daniellaf17, updated more than 1 year ago
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Created by daniellaf17
over 10 years ago
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| Question | Answer |
| Pharmacokinetics | Study of how a drug is: (ADME) A-absorbed D-distributed M-metabolised E-eliminated what the body does to drug |
| Routes of administration | *Oral *Intravenous *Subcutaneous *Intramuscular *Transdermal *Inhalation All Ds = vascular compartment |
| Oral administration | *Most convenient *Slow release impairs absorption *Enteric coated tablets = Not dissolved until reaching small intestine |
| First-pass effect 1 | |
| First-pass effect 2 | |
| First-pass effect 3 | |
| Parenteral drug administration (List 4) | |
| Parenteral drug administration (definitions) | |
| Parenteral drug administration (absorption etc.) | *SC-absorption slower than IV *IM- absorption in aqueous sol. fast & deposited preparations slow *IV-rapid effect, maximal control over circulating [D] |
| Sublingual administration | Place under tongue = D into capillary network =directly into systemic circulation *Bypasses liver &GIT = no first-pass metabolism |
| Rectal administration | *Half of rectal blood drainage bypasses portal circulation = less biotransformation of D *Useful- Vomiting(anti-emetics) & unconscious pts |
| Inhalation administration |
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