501570
Description
Flashcards by Mark George, updated more than 1 year ago
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Created by Mark George
over 10 years ago
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| Question | Answer |
| Pernicious anaemia Patho | Lack of IF (Intrinsic Factor) IF secreted by gastric parietal cells Loss of parietal cells-> IF deficiency -> B12 deficiency -> PA |
| IF | Intrinsic Factor enzyme responsible for absorption of dietary B12 |
| Deficiency in IF secretion Cause? | 1. Congenital 2. Gastric mucosal atrophy - chronic gastritis type A (autoimmune) 3. Strict vegan diet (B12 comes from animal sources) |
| PA evaluation | 1. blood test & BM aspiration 2. Schilling test = urinary excretion of B12 3. serologic studies = parietal cells & IF antibodies 4. gastric biopsy = lack of HCI |
| PA treatment | 1. B12 replacement by injection or 2. Oral admin in larger doses 3. fatal if untreated (cardiac failure) |
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