536653
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 10 years ago
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| Question | Answer |
| PAMP's | Pathogen Associated Molecular Patterns |
| Role of PAMP's | Vital to metabolic processes of most antigens and so occur in all of them (with some variation) |
| PRR's | Pattern Recognition Receptors |
| Role of PRR's | Recognise PAMP's - broad specificity due to PAMP variation |
| Antibodies on B- Cells | Either membrane bound or secreted (known as immunoglobulins) |
| Specificty of B-Cells | High- specific for one antigen |
| T Cell Receptors | Membrane bound Ig's specific to T cells (different shape to B-Cell antibodies) |
| Epitopes | Part of antigen recognised by Ab's - can be continuous or discontinuous |
| Domains | Basic units of Ib's |
| L Chain Domains | 2- 1 variable, 1 constant |
| H chain Domains | 1 Variable, 3-4 constant |
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Image:
Antibody_Fab (image/jpg)
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Fab Domain- can rotate & bend to aid Ag binding |
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Image:
Antibody_FaC (image/jpg)
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Fac- can 'wag' to aid binding |
| 3 Hypervariable Regions | Present in the variable domains, which form CDR loops |
| CDR | Complimentarity Determining Regions |
| Role of CDR | Some will bind to specific antigen (though not necessarily all- some are just for recogniton, not binding) |
| Role of Ig's- Opsonisation | Coating of pathogen so phagocytes can recognise Fc's |
| Role of Ig's- Compliment Stabilisation | Allows compliment to Opsonise pathogen & activates further compliment cascade |
| Role of Ig's- Neutralisation | Binds to pathogen preventing invasion & blocking action of the toxin |
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