Beta2-Agonists

Andrew Street
Flashcards by , created about 3 years ago

Top 100 drugs.

2
0
0
Andrew Street
Created by Andrew Street about 3 years ago
Tis Pity She's a whore- Key quotations
charlottedarling
AQA A2 Biology Unit 5 Chapter 11: Muscle Contraction
Charlotte Lloyd
2.1.3 Software
Lavington ICT
Algebra - Expansion of Brackets
jerick_hartono
Body Systems Revision
D Arora
Adenosine
Andrew Street
Acetylcysteine (N-acetylcysteine)
Andrew Street
FORMOTEROL
Andrea McMann
VENTOLÍN®
mg cicles
AQA GCSE Chemistry Unit 2.3
Matthew T
Question Answer
Give eg's of & indications for beta2-agonists. eg's: salbutamol & terbutaline (short acting). Salmeterol & formoterol (long acting). Long acting β2-agonists may be combined in an inhaler with a steroid, eg Symbicort or Seretide Indications: * Asthma - short-acting β2-agonists are used to relieve breathlessness. Long-acting β2-agonists are used as ‘step 3’ Rx for chronic asthma, but must always be given in combination with inhaled corticosteroids. * COPD - short-acting β2-agonists are used to relieve breathlessness. Long-acting β2-agonists are an option for 2nd line therapy of COPD. * Hyperkalaemia - nebulised salbutamol may be used as an additional Rx (alongside insulin, glucose & calcium gluconate) for the urgent Rx of a high serum potassium concentration.
MOA of B2-agonists. Beta2-receptors are found in smooth muscle of the bronchi. Stimulation of this G protein-coupled receptor activates a signalling cascade that leads to smooth muscle relaxation (Gs → ↑AC → ↑cAMP → ↓Ca2+ & ↑PKA = ↓MLCK). β2-agonists also stimulate Na+/K+-ATPase pumps on cell surface membranes, thereby causing a shift of K+ from the extracellular to intracellular compartment. This makes them a useful adjunct in the Rx of hyperkalaemia. Beta2-agonists are classified as short-acting (salbutamol, terbutaline) or long-acting (salmeterol, formoterol) according to their duration of effect.
SE's of beta2-agonists. • Tachycardia • Palpitations • Anxiety • Tremor • Muscle cramps (long-acting)
CI's, cautions, & important interactions of beta2-agonists. CI's: • None Cautions: • Long-acting β2-agonists should be used in asthma only if an inhaled corticosteroid is also part of therapy. • Cardiovascular disease Important interactions: Beta-blockers may reduce the effectiveness of β2-agonists. Concomitant use of high-dose nebulised β2-agonists with theophylline and corticosteroids can lead to hypokalaemia, so serum potassium concentrations should be monitored.