71599
Description
Flashcards by Jeni Thomas, updated more than 1 year ago
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Created by Jeni Thomas
almost 13 years ago
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| Question | Answer |
| Risk Factors for atherosclerosis? | Age, Smoking, Lack of exercise, High cholestrol diet, |
| Layers of vessel wall? | |
| Where is cholesterol synthesised? | Liver |
| Main reason for atherosclerosis formation is endothelial dysfunction, how does this happen? | smoking hypertension |
| Where does atherosclerosis mainly occur? | Areas where disturbance in blood flow occurs - bifurcation, branches off blood vessel, low lamina flow. |
| What lipoprotein carries cholesterol from the liver to the peripheral tissues? | Low Density Lipoprotein |
| What does the high density lipoprotein do? | Carry excess cholesterol from the 'overflow' situation in periphery back to the liver. |
| When in excess LDL can go into the intima and become oxydised - what is the effect of this? | oxydised LDL is pro-atherogenic |
| What does a macrophage become once it ingests lipid? | Foam cell |
| Function of cholesterol in the body? | precursor for steroidal hormones precursor for Vit D3 waterproofing of epidermis (skin) component of cell membranes |
| When endothelial cell is damaged what does it release? | Van Willerband Factor -act like hooks which connect with platelets (form platelet plug) |
| What causes the inflammation? | Coagulation (platelet plug) LDL's |
| How does the fatty streak formation form? | Continued LDL deposition below the tunica intima |
| What do the macrophages do? | Engulf LDL and become foam cells |
| Symptoms of atherosclerosis? | Depends which vessel -coronoray artery disease (angina with activity) -claudication (pain in peripheral with activity, ischemia) -brain (TIA) |
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