PHOL1001

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Flashcards on PHOL1001, created by Margaret-Estefani Conde Paredes on 25/02/2017.
Margaret-Estefani Conde Paredes
Flashcards by Margaret-Estefani Conde Paredes, updated more than 1 year ago
Margaret-Estefani Conde Paredes
Created by Margaret-Estefani Conde Paredes over 7 years ago
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Question Answer
What are the criteria for a neurotransmitter (NT)? - presence -stored in vesicles -release -effect -termination of effect
What are the characteristics of transmitters in CNS? -always agonists -can produce fast or slow events -can excite or inhibit -determined by receptors -ion channel-fast-neurotransmission - 2nd messengers-slow-neuromodulation
What are the characteristics of receptors? -determine the effects of transmitters and drugs -excitatory or inhibitory - never both -fast (msecs) or slow (sec to min) effects -subtypes- can result in mixed effects
What is the role of pre-synaptic receptors? Pre-synaptic receptors alter NT release (WHERE THEY CONTROL TRANSMITTER RELEASE)
What is the role of post-synaptic receptors? Post-synaptic receptors alter activity (CONTROLLING NEURONAL FIRING)
What are the main types of neurotransmitters and their effects? *glutamate: major excitatory transmitter *GABA: major INHIBITORY transmitter -Acetylcholine: mixed effects -Noradrenaline: mixed effects -5HT: mixed effects -Dopamine: mixed effects > peptides- substance P (excitatory) -opioids (inhibitory) > nitric oxide: excitatory > adenosine: inhibitory
What are the features of glutamate? * major excitatory transmitter in CNS * most neurones respond to glutamate * often found in long pathways * point to point transmission * can cause long term changes
Which four receptors act glutamate on? 1. AMPA postsynaptic receptor (ionotropic) 2. NMDA postsynaptic receptor (ionotropic) 3. fast presynaptic excitatory KAINATE receptor 4. slow METABOTROPIC receptors (G-proteins)
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