CLOSTRIDIUM DIFFICILE

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Mind Map on CLOSTRIDIUM DIFFICILE, created by Sandra Jiménez on 24/04/2020.
Sandra  Jiménez
Mind Map by Sandra Jiménez, updated more than 1 year ago
Sandra  Jiménez
Created by Sandra Jiménez over 4 years ago
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Resource summary

CLOSTRIDIUM DIFFICILE
  1. Bacilo Gram-positivo anaerobio esporulado
    1. Mircroflora natural del intestino
      1. Sintetiza 2 tóxinas
        1. Enterotoxina (toxina A)
          1. Quimiotáctica para neutrófilos
            1. liberación de citocinas
              1. Efecto citopático
                1. Incremento permeabilidad pared intestinal
                  1. DIARREA
          2. Citotoxina (toxina B)
            1. Provoca despolimerización actina
              1. Destrucción del citoesqueleto celular
        2. EXPOSICIÓN PROLONGADA A ANTIBIOTICOS
          1. Crecimiento excesivo C.Difficile
          2. PX inmunocomprometido
            1. CLINICA
              1. Diarrea acuosa leve-moderada
                1. Colitis sin formación de pseudomembranas
                  1. Fiebre, diarrea acuosa con o sin sangre, nauseas, dolor abdominal,leucocitosis,
                  2. Colitis pseudomembranosa
                    1. Dolor abdominal, diarrea con sangre, fiebre, hipoalbuminemia
                      1. + GRAVE
                    2. DIAGNOSTICO
                      1. Cliníca
                        1. Cultivo
                          1. Endoscopia
                            1. TAC
                            2. TRATAMIENTO
                              1. Suspender Antibioticos implicados
                                1. Metronidazol o Vancomicina
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