1523052
Noses
- Structure
- Sinus
- Mucus formed and filled up
- Mucus formed and filled up
- Olfactory bulb
- Main site of smelling
- Main site of smelling
- Turbinate
- Main site of drug absorption
- Contain lots of folds,
large surface area
- Main site of drug absorption
- Cilia
- Rymthmic beating action
- drain mucus away from the nose
- Defence against infection, toxins and allergens
- on turbinate
- drain mucus away from the nose
- Rymthmic beating action
- Connect the ears and mouth
- infection in nose/lungs may affect ears and mouths
- infection in nose/lungs may affect ears and mouths
- Sinus
- Fuction
- Breathing
- smelling
- Breathing
- Benefits of nasal drug delivery
- Avoid passing BBB
- BBB requires lipophilic drug to pass through
- A special circulatory system
- Allow delivery of hydrophilic drug
- Allow delivery of hydrophilic drug
- BBB requires lipophilic drug to pass through
- Avoid metabolised by the liver
- contains enzyme
that might degraded
drugs
- contains enzyme
that might degraded
drugs
- new forms and drug/ vaccine delivering
- user friendly
- less pain
- user friendly
- Application
- localized
- systematic
- localized
- Dosage form flexibility
- Avoid passing BBB
- Factor affect nasal dosage form
- Nasal metabolism
- Nose has a first metabolic rate
- Nose has a first metabolic rate
- illness
- Extra mucus produce
- Extra mucus produce
- physical barrier
- Mucus
- Mucus
- resistance time/ clearance
- pH
- pKa should be match with nose
- pKa should be match with nose
- particle size
- too big
- Stuck in
outside of
nose
- Stuck in
outside of
nose
- too small
- Go down the
lungs
- Go down the
lungs
- too big
- Nasal metabolism
Want to create your own Mind Maps for free with GoConqr? Learn more.