BLOOD

BLOOD

1 Leukocytes

1.1 Granulocyte

1.1.1 Neutrophil

1.1.1.1 nucleus

1.1.1.1.1 Old: Lobulated/Segmented nucleus

1.1.1.1.2 Young: U shaped Nucleus>Band Cell

1.1.1.1.3 Accessory lobe

1.1.1.1.3.1 Barr Body in female

1.1.1.2 Granules

1.1.1.2.1 Azurophilic (primary)

1.1.1.2.2 Specific (secondary)

1.1.1.2.3 Tertiary

1.1.1.3 Myeloperoxidase (green color)

1.1.1.3.1 pus(หนอง)

1.1.1.3.2 Mucous

1.1.1.3.3 Buffy coat

1.1.1.4 Phagocyte

1.1.2 Eosinophil

1.1.2.1 Bilobed nucleus

1.1.2.2 Eosinophilic granules

1.1.2.2.1 Horse: bright red granules เต็ม cytoplasm

1.1.2.3 Phagocyte

1.1.2.4 Eo+Mast+Basophilic--> allergy&asthma

1.1.2.5 Eosinophilia - pararsitic infestation

1.1.3 Basophil

1.1.3.1 Bilobed or irregular shaped nucleus

1.1.3.2 Basophilic granules

1.1.3.3 dark blue-purple stained

1.1.3.4 Involved in inflammatory, allergic

1.1.3.5 Produce

1.1.3.5.1 Histamine

1.1.3.5.2 Heparin

1.2 Agranulocyte

1.2.1 Lymphocyte

1.2.1.1 Dark stain nucleus (เข้มสุด)

1.2.1.2 Large round nucleus

1.2.1.3 SHAPE

1.2.1.3.1 Small

1.2.1.3.2 Large

1.2.1.3.2.1 Large granular lymphocyte

1.2.1.3.2.1.1 Natural Killer cell

1.2.1.4 DUTY

1.2.1.4.1 T-cell

1.2.1.4.1.1 Helper (CD4)

1.2.1.4.1.2 Cytotoxic (CD8)

1.2.1.4.1.3 Memory

1.2.1.4.1.4 Pegulatory

1.2.1.4.2 B-cell

1.2.1.4.2.1 Plasma (antibody)

1.2.1.4.2.2 Memory

1.2.1.4.3 Natural Killer cell

1.2.2 Monocyte

1.2.2.1 Largest WBC

1.2.2.2 Kidney shaped nucleus

1.2.2.3 Phagocyte

1.2.2.4 Store in spleen 50%

1.2.2.5 Vacuoles

2 Platelets

2.1 No nucleus

2.2 Fragment of Megakaryocyte

2.3 3 steps to stop bleeding

2.3.1 1)adhesion

2.3.2 2)activation

2.3.3 3)aggregation

2.4 concentration

2.4.1 Low: Thromcocytopenia

2.4.2 High: Thrombocytosis

3 Erythrocytes

3.1 Erythropoieses (build)

3.1.1 Bone Marrow

3.2 Eryptosis (destroy)

3.2.1 spleen

3.2.2 liver

3.2.3 lymph node

3.3 Stucture

3.3.1 No nucleus

3.3.2 Biconcaved disk

3.3.3 lifespan: 120 days

3.3.4 Heme = Iron+Bilirubin (yellow)

3.4 Delivering

3.4.1 Hemoglobin + O2 = Oxyhemoglobin (red)

3.4.2 Hemoglobin wuthout O2 = Deoxyhemoglobin (dark red)

3.4.3 Hemoglobin + CO = Carboxyhemoglobin (bright red)

3.5 Effects of osmolarity to RBC

3.6 Rouleaux formation

3.6.1 Cause: high plasma protein

3.6.2 Result: Upper erythrocyte sedimentation rate (ESR)

3.7 Abnormal

3.7.1 Anisocytosis

3.7.1.1 Macrocyte

3.7.1.2 Microcyte

3.7.2 Poikilocytosis

3.7.2.1 Hypochromasia

3.7.2.2 Basophilic stippling

4 Preparing thin film blood smear

4.1 Romanowsky dye: Wright's stain, Giemsa

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	Created by Chutikan Srisang over 5 years ago