355199
Description
γδ-T cells
- Therapeutic use
- cancer immunotherapy
- availability of synthetic drugs such as
zoledronate, pamidronate and
phosphoantigen BrHPP (Bromohydrin
Pyrophosphate) etc that selectively
activate γδ T cells has allowed for γδ T
cells to be used for clinical trials.
- cancer immunotherapy
- Role in humans
- Immunoregulation
- Infectious disease
- HIV
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- IL- 4, IL-5, IL-13 and IL-17 against extracellular pathogens
- TNF and IFN-γ are involved in acting against viruses and intracellular pathogens
- HIV
- Cancer
- IFN-γ, IL-6 and GM-CSF are implicated in tumour-induced inflammation
- Cancer Immunotherapy
- recognise and migrate to tumour sites their and attack
tumours
- recognise and migrate to tumour sites their and attack
tumours
- IFN-γ, IL-6 and GM-CSF are implicated in tumour-induced inflammation
- autoimmune/hypersensitivity
- IL-4 and IL-13 are involved
in asthma and allergy
reactions
- IL-4 and IL-13 are involved
in asthma and allergy
reactions
- Immunoregulation
- Subsets
- Vδ1
- spleen, thymus,dermin, liver and gut epitelia
- predomintate during fetl
and early life in PB,
minotrity in adults
- spleen, thymus,dermin, liver and gut epitelia
- Vγ9Vδ2 most abundant
- peripheral blood
- Tnaive
- TCM Central memmory
- TEM Effector memmory
- TEMRA
- IL-17 producers
- peripheral blood
- Vδ3
- liver and gut epithelia
- liver and gut epithelia
- expression of the V regionn of the gd TCR chians
- Vδ1
- Background
- Gamma/delta T cells form a unique subset of CD3+ T
lymphocytes expressing structurally distinct γδ
heterodimers as their antigen receptors
- under 10 % of the total T cell count in the body
- both innate effector functions and adaptive
immune response
- cause antibody dependant cell
mediated cytotoxicity (ADCC) via
the FC γRIII (CD16) receptors
followed by rapid secretion of
cytokines and chemokines
- respond to
phosphoantigens (of
microbial origin) and are
activated to proliferate and
carry out their immune
effector functions
- Once activated cause
present antigens to
CD4+ and CD8+ cells
- activated by low
molecular non peptide
phosphoantigens
- IPP, HMBPP
- secrete cytolytic factors such as granzymes and
perforins, along with chemokines (eg.
Lymphotactin, RANTES) and immunomodulatory
cytokines such as TNF, IFN-γ, IL-4, IL-5, IL-6,
IL-17, IL-13, IL-22, and GM-CSF
- against invading pathogens or endogenous stress.
- against invading pathogens or endogenous stress.
- IPP, HMBPP
- Once activated cause
present antigens to
CD4+ and CD8+ cells
- γδ T cell arise from DN2 and DN3 stage
- receptors similar to
those found on
NK cells
- involved in tissue repair and
epithelial cell regeneration
- Gamma/delta T cells form a unique subset of CD3+ T
lymphocytes expressing structurally distinct γδ
heterodimers as their antigen receptors
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