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445910
Week 2
Description
Undergraduate Degree BMSC1110 (week summary) Mind Map on Week 2, created by 06watkinse on 17/12/2013.
No tags specified
bmsc1110
undergraduate
week summary
bmsc1110
undergraduate degree
Mind Map by
06watkinse
, updated more than 1 year ago
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Created by
06watkinse
over 10 years ago
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Resource summary
Week 2
Connective Tissues
Pluripotent
Involved in
Packaging and dividing
Providing support
Energy storage
Space filling
Contains
Lipoblasts
Myofibroblasts
Mast cells
Macrophages
Plasma cells
Extra cellular matrix
structural carbohydrates
structural proteins
ground subsance
Glycoaminoglycans
unbranched polysaccharides
4 different groups
hydrophobic
Aggrecan
chondroitin suphate and keratan sulphate
found in cartilage
regulates cellular signals/migration
Syndecan
Heparan sulphate
found on the plasma membrane
facilitates cellular interactions
Fibronectin
dimer
joined by disulphide bonds
adhers cells to components in the ECM
CT Fibres
Elastin
750 amino acid sequence
elastic, allows stretch
secreted as elastin molecules and assembled in the ECM
form cross links between fibres
Collagen
fibrous proteins
long, stiff, unbranched, triple helix
secreted as single chains that wind together in the ECM
Connective Tissue Types
Fibrocollagenous
Dense
Regular
parallel
withstand forces in one direction
Irregular
interwoven collagen and elastin fibres
withstand forces from different directions
Areolar/Loose
abundant in ground substance
many cell types
some collagen and elastin fibres
Reticular
reticulin fibres
form a fine network around epithelial cells
Cartilage
formed from a chondroblast maturing into a chondrocyte
ECM made of aggrecan and fibres
avascular
hyaline
lubricate joints
nose, ribs, ends on bones
fibrocartilage
strong
IVDs and knee joint
elastic
ear and epiglottis
thin and flexible
Bone
osteoprogenitor to osteoblast to osteocyte
ECM is osteoid
25% organic - collagen and GAGs
75% inorganic - hydroxyapatite
Diseases
Rickets
Vitamin D deficiency
bone softening
causes weak bones
treated with vitamin D supplements
Ehlers - Danlos Syndrome
inherited
defect in collagen synthesis
effects the following structures
skin - stretchy, fragile, bruising
joints - hyperflexability, dislocation
bones - osteopenia, osteoarthritis
ligaments - stretchy
blood vessels - fragile, aneurysm, stroke
The Skeleton
Axial
skull
bones
parietal
temporal
frontal
mandible
fetal skull
contains suture lines filled with cartilage
soft spot
overly soft - dehydrated
hard - intercranial pressure
functions
protection
special senses
uscular attachment
upper respiratory/digestive tracts
mastication muscles
massater
temporalis
lateral and medial pterygoid
thoracic cage
formed from 12 ribs and the sternum
protects thoracic viscera
helps with breathing
main muscle is the diaphragm
3 intercostal muscles
innermost
internal
external
each space between the ribs contains a intercoastal vein, artery and nerve.
vertebral column
5 regions
cervical - 7
thoracic - 12
lumbar - 5
sacral - 5 (fused)
coccygeal - 4 (fused)
curvature
kyphosis - thoracic curve
lordosis - lumbar curve
scoliosis - lateral curve
vertebrae
vertebral body
vertebral foramen
superior articular process
transverse process
spinous process
lamina
pedicle
inferior articular process
each section of the column have different morphology
intervertebral disc
annulus fibrosis surrounds the outside of the disc
concentric lamellae, fibrocartilage
nucleus pulposus makes up the centre of the disc
hydrophilic, gelatinous ball
aid movement
shock absorbers
a slipped disc is when the nulcleus pulposus leaks into the vertebral foramen and presses on the spinal cord
Appendicular
upper limb
regions
axilla
arm/brachium
cubital fossa
forearm/antebrachium
pectoral girdle
subscapular fossa
glenoid cavity
coracoid process
clavicle
supraspinous fossa
spine
acromian
infraspinous fossa
musculature
trapezius - shrugging
levator scapulae - shrugging
major and minor rhomboids - abduction
latissimus - shoulder retraction
deltoids - flexion, extension and adduction
pectoralis - protraction
serratus anterior - clamps the scapula to the ribs
movements
flexion/extension
ab/adduction
circumduction
winged scapula
damage to the long thoracic nerve
inhibition of nerve stops stimulation of serratus anterior
rotator cuff muscles
reinfirce joint capsule
hold humorus in cavity
supraspinatus - abduction
infraspinatus - lateral rotation
teres minor - lateral rotation
subscapularis - medial rotation and adduction
discolations
shoulder
excessive extension and lateral rotation
drops inferiorly and medially
elbow
falling on outstretched hand with elbow flexed
posterior and superior
damage to ulnar/radial nerve can paralyse each half of the hand
elbow
hinge joint
humeroulnar
humeroradial
proximal radioulnar
collateral ligaments reinforce the radius and ulnar
annular ligament sits over the radius and hold it in place next to the ulnar to allow supination and pronation
muscles
biceps brachii - supinator flexor
brachiallis - flexor
triceps brachii - exetensor
epicondylitis
golfers elbow - medial
tennis elbow - lateral
inflamation of muscle insertion points
lower limb
Body Cavities
Dorsal Cavity
protects nervous system
cranial cavity - brain
vertebral cavity - spinal cord
Ventral
houses internal organs
thoracic cavity
abdominopelvic
abdominal
stomach, intestines, spleen, liver
trauma
evisceration
laceration can cause organs to protude from the body
closed injuries
blunt trauma
without breaking the skin
compression trauma caused by deceleration forces
organs
hollow
structures that materials pass through
when lacerated contents spill into the peritoneal cavity
contents when spilt cause peritonitis
solid
perform chemical work of the body
high blood content causes severe haemorrhage if lacerated
injury can be overshadowed by shock
liver injury
second most common
difficult to manage surgically
associated with other injuries
spleen injury
common in car accidents
infection it becomes enlarged
pain present in left shoulder - refered pain
pain in lower left ribs
kidney injury
rarely seen
well protected area
forceful blow/penetrating injury
abrasion, contusion, laceration or haematoma in the flank
fractures to lower ribs or lower thoracic/upper lumar vertebrae
pelvic
bladder, reproductive, rectum, anal canal
split in 2
greater pelvis superior to pelvic brim
lesser pelvis between pelvis inlet and outlet
pelvic brim separates
there are many differences
pelvic floor
structure
muscular layer
3 midline orifices
function
supports viscera
resists intra abdominal pressure
female reproductive organs
primary
ovaries
secondary
external
labia major and minor
pubis
clitoris
ducts
uterine tubes
connect ovaries to uterus
infundibulum - funnel shaped, fimbrae on edges
ampulla - site of fertilisation
isthmus - most medial portion
uterus
3 layers - peri, myo and endo metrium
anatomy - fundus, body, isthmus, cervix
disposition
anteflexed
excessive anteflexion
retroverted retroflexion
retroverted anteflexed
fibroids
non-cancerous growths
variable size and location
symptoms - pain and bladder and bowel problems
treatment - myomectomy, uterine artery embolism and hysterectomy
vagina
glands
greater vestibular gland
injury
rarely damaged
exception is during pregnancy
maternal changes
obstruction of vena cava
increasing maternal blood volume
uterus is thick and muscular - distributes trauma uniformly to fetus
male reproductive organs
primary
testes
enclosed in scrotal sac
scrotal sac
ductus deferens
blood vessels
nerves
enclosed in muscular sheath
secondary
external
penis
scrotum
ducts
efferent ductules
vas deferens
ejaculatory duct
urethra
glands
seminal vesicle
prostate
sits under bladder
urethra passes through
4 lobes
transurethral resection of prostate
resectoscope - electric current is run through a loop of wire to heat it
cuts away section of prostate
benign prostatic hyerplasia
bulbourethral
composition of semen
sperm - 3-5% - testes
semen - 65-75% - seminal vesicles
prostatic fluid - 25-30% - prostate
Injury
pelvis
blunt trauma
skeletal damage - pubis fracture
life-threatening haemorrhage
potential organ damage
bladder
rupture - unrine spills into cavirty
sudden deceleration can shear bladder rom urethra in males
peritoneum
serous membrane surrounding the cavity
visceral lines the organs
parietal lines the body wall
peritonal cavity filled with fluid to reduce friction
ascites - build up of fluid in the cavity
quadrants
right upper
left upper
right lower
left lower
regions
right/left hypochondriac
right/left lumbar
right/left iliac
epigastric
umbilical
hypogastric
separated by the diaphragm
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