null
US
Sign In
Sign Up for Free
Sign Up
We have detected that Javascript is not enabled in your browser. The dynamic nature of our site means that Javascript must be enabled to function properly. Please read our
terms and conditions
for more information.
Next up
Copy and Edit
You need to log in to complete this action!
Register for Free
559038
Drug discovery
Description
Advanced Molecular Biology & Biotechnology Mind Map on Drug discovery, created by Abbey Roberts on 18/02/2014.
No tags specified
advanced molecular biology & biotechnology
advanced molecular biology & biotechnology
Mind Map by
Abbey Roberts
, updated more than 1 year ago
More
Less
Created by
Abbey Roberts
over 10 years ago
44
0
0
Resource summary
Drug discovery
drugs can have many definitions
substance used in the diagnosis, treatment, or prevention of a disease or as a component of a medication
any biological or chemical substance (synthetic or non-synthetic)
anything that affects the way an organism works
can be taken to enhance function
there are many key points
target can be a specific cell type, protein or molecule
are administrated to patients (individuals who have the disease)
ways of measuring
can measure the disease
can measure the effect of the drug
cell death/growth
changes in levels
Pharmacogenomics/Pharmacogenetics
impact on drug discovery and development
How do we get drugs to work?
target validation is key
proteins target have many domains/motifs which each has a different function
domains can localise proteins
domains can bind to other proteins
domains can bind to other molecules
most proteins have multiple domains
proteins have many functions
How drugs are discovered?
disease is anything that can affect the proper functioning of a body
infection
genetic disorder
result of environmental conditions (malnourishment, poisoning, stress)
most of the work in our body is done by proteins
contains thousands of types of proteins
construction of each is determined by the DNA in the nucleus of each cell
DNA contains instruction of how to build a specific protein
How drugs are developed?
Non-clinical drug development
stages in drug discovery process
animal testing
Problem of one vs several chemical
Drugs and plants
Differences and similarities of drugs and medicinal plants
there are many plant based medicines and drugs
need for consumer education about herbal supplements and drugs
different boards and committees
FDA
Institutional Review Board
drug discovery is anything but cheap
company mainly wants value whereas Contract Research Organisations mainly want good understanding of chemistry and competitive price
most drugs fail after considerable expense
failure at Phase 3 could loose company 10% of share value
successful drug could cost between £100 million to over £1 billion from discovery phase to market
increases company share value
money comes from customers and drives future drug discovery
Show full summary
Hide full summary
Want to create your own
Mind Maps
for
free
with GoConqr?
Learn more
.
Similar
Recombinant DNA technology
Abbey Roberts
Control of gene expression in Eukaryotes
Abbey Roberts
Drug Design Chapter 2: Drug Discovery, Design, and Development (Part 1)
gibbons530
Biotechnology analysis methods
Abbey Roberts
Control of gene expression in Prokaryotes
Abbey Roberts
DMPK intro
Zena Dodds
Difference between prokaryotic and eukaryotic gene regulation
Abbey Roberts
Recombinant DNA technology
hmayger08
Recombinant DNA technology
EMMANOUIL POLITIS
Pathos in Battle
mouldybiscuit
Mapa Conceptual
Julio Perez
Browse Library