CYSTIC FIBROSIS SHAHIN

shahin kadiri
Mind Map by shahin kadiri, updated more than 1 year ago
shahin kadiri
Created by shahin kadiri almost 5 years ago
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MIND MAPPING

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CYSTIC FIBROSIS SHAHIN
  1. Autosomal Recessive
    1. Mutation In CFTR gene
      1. CFTR protein
        1. Channel Protein
          1. Pumps Cloride (CL)
            1. Production of Sweat , Digestive fluids and mucus
              1. Mutation
                1. ΔF508
                  1. Deletion Of Phenylalanine on the 508/1408 Amino Acid
                    1. CFTR Protein Is misfolded
                      1. No Migration from the ER TO CM , so no Chloride ions out
            2. NEW BORN BABIES
              1. Meconium Ileus
                1. Meconium : First stool
                  1. Stuck In Babies intestine
                    1. Surgical emergency
              2. EARLY CHILDHOOD
                1. Blocked pancreatic ducts
                  1. NO PANCREATIC ENZYME
                    1. NO ABSORBTION OF FATS AND PROTEINS
                      1. steatorrhoea : stool with fat containing
                        1. FIX PANCREATIC ENZYMES
                2. LATER IN CHILDHOOD
                  1. LUNGS PROBLEMS
                    1. Cilia can't get rid of all the mucus
                      1. Bacteria Increase
                        1. COUGH
                          1. FEVER
                            1. ANTIBIOTICS
                              1. RESISTANT
                                1. Biofilm
                                  1. Protects Bacteria
                                    1. IMMUNE SYSTEM
                                      1. ANTIBIOTICS
                                    2. BATCERIA
                                      1. Staphelococcus Auerus
                                        1. +
                                        2. Psedomanus
                                          1. -
                                          2. inflamation
                                            1. CHROIONIC
                                              1. BRONCHIETASIS
                                                1. DIALATION OF BRONCHI
                                                  1. COUGHING BLOOD
                            2. IN MEN
                              1. INFERTILITY
                                1. LACK OF VAS DEFERNS
                                  1. TUBES BETWEEN TESTIS AND URETHRA
                                2. DIGITAL CUBBINGS
                                  1. NAILS
                                  2. NASAL POLYPS
                                    1. TISSUE GROWS IN NOSE
                                  3. DIAGNOSIS
                                    1. NEW BORN SCREENING
                                      1. DETECT P.E IRT
                                        1. RELEASED IN BLOOD WHEN PANCREAS IS DAMAGED
                                      2. SWEAT TEST
                                        1. HIGH CL SKIN TASTY
                                      3. Treatment
                                        1. FAT SOLUBLE VITAMINS ( A, D, E , K )
                                          1. REPLACEMENT OF P.E
                                            1. INHALERS , CHEST PHYSIOTHERAPY
                                              1. LUNG TRANSPLANT
                                                1. LUMACAFTOR & IUCAFTOR
                                                  1. BRINGS BACK ΔF508
                                                2. Medications
                                                  1. N-ACETYLCYSTEINE
                                                    1. CLEARS DISULFADE BONDS
                                                    2. DORMASE ALFA-NUCLEASE
                                                      1. CUTS NUCLEIC ACID IN MUCUS SO IT BECOMES THIN
                                                    3. SYMPTOMS
                                                      1. WHAT IS IT?
                                                        1. RECESSIVE MUTATION IN CFTR GENE THAT ENCODES FOR CFTR PROTEIN
                                                          1. CFTR PROTEIN
                                                            1. A PROTEIN CHANNEL PUMPS CL
                                                              1. MOST COMMON MUTATION IS ΔF508/1408
                                                                1. DELETION OF PHENYLALANINE ON THE 508TH AMINO ACID
                                                                  1. CFTR PROTEIN IS MISFOLDED NO MORE PUMPING CL
                                                          2. LEVEL OF CF
                                                            1. NEWBORN BABY
                                                              1. INTESTINE
                                                                1. STUCK BECAUSE OF THE THICKNESS OF THE FIRST STOOL IN THE INTESTINE
                                                                  1. MECANIUM
                                                                    1. MECAMIUM ILEUS
                                                              2. EARLY CHILDHOOD
                                                                1. PANCREAS
                                                                  1. FATS AND PROTEINS AREN'T ABSORBED
                                                                    1. STEATORRHEA
                                                                      1. FAT CONTAINING STOOL ( ITS NOT ABOSRBED SO GOES OUT AS A STOOL )
                                                                2. LATE CHILDHOOD
                                                                  1. LUNGS
                                                                    1. CILIA FINDS IT DIFFICULT TO KICK MUCUS OUT TO PHARNYX
                                                                      1. A LOT OF MUCUS CAUSES BACTERIA ACCUMILATION
                                                                        1. INFECTIONS
                                                                          1. COUGH AND FEVER
                                                                            1. ANTIBIOTICS
                                                                  2. MEN
                                                                    1. VAS DEFERES
                                                                      1. INFERTILITY LACK OF SPERM TUBES FROM TESTIS TO URETHRA
                                                                      2. DIGITAL CUBBINGS
                                                                        1. NAILS
                                                                        2. NASAL POLYPS
                                                                          1. TISSUE GROWTH IN NOSE
                                                                      3. DIAGNOSIS
                                                                        1. NEWBORN SCREENING
                                                                          1. IRT RELEASED TO BLOOD WHEN PANCREASE IS DAMAGED
                                                                            1. SWEAT TESTING
                                                                          2. TREATMENT
                                                                            1. FAT SOLUBLE VITAMINS
                                                                              1. REPLACEMENT OF PANCREATIC ENZYMES HELPS PATIENT ABSORB NEUTRIENTS
                                                                                1. MEDICATIONS
                                                                                  1. N-ACETYLCYSTEINE
                                                                                    1. DORANSE ALFA NUCLEASE
                                                                                    2. LUMACAFTOR AND IUCAFTOR HELPS ΔF508 TO WORK BACK AGAIN
                                                                                      1. PULMONARY TREATMENT
                                                                                        1. CHEST PHYSIOTHERAPY
                                                                                          1. INHALERS
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