ANTIBIOTICS-1

naila.k.ferris
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Mind Map on ANTIBIOTICS-1, created by naila.k.ferris on 03/17/2014.

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naila.k.ferris
Created by naila.k.ferris over 5 years ago
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ANTIBIOTICS-1
1 Inhibition of cell wall synthesis

Annotations:

  • bind to cyto PBP, inh. transpeptidation, inh. cross-linking of bacterial cell wall
1.1 PENICILLINS, CEPHALOSPORINS,
1.1.1 IMIPENEM, MEROPENEM, ASTREONAM VANCOMYCIN

Annotations:

  • vancomycin - Inhibits peptidoglycan synthases bind to D-Alanine
1.1.2 B-lactamase cleavage of drugs B-lactam ring
2 Inhibition of protein synthesis
2.1 Interfere with formation of initiation complex
2.1.1 BACTERICIDAL

Annotations:

  • misread genetic code carried by mRNA resulting in the incorperatino of wrong aa
2.1.1.1 AMINOGLYCOSIDE (30S), LINEZOLID (50S)
2.1.1.1.1 production of conjugatingenzymes that increase drugs clearance
2.2 Interfere with incorporation of next aa
2.2.1 BACTERIOSTATIC

Annotations:

  • inh. insertion of aminoacyl t-RNA into "A" site
2.2.1.1 TETRACYCLINS (30S), DILFOPRISTIN & QUINUPRISTIN (50S)
2.2.1.1.1 production of active transport systems that push drugs out of the cell

Annotations:

  • tetracyclins
2.3 Interfere with formation of peptide bond
2.3.1 BACTERIOSTATIC

Annotations:

  • inh. peptidyltransferase
2.3.1.1 CHLORAMPHENICOL
2.3.1.1.1 formation of acetylating ensymes that inactivate drugs

Annotations:

  • chloramphenicol
2.4 Interfere with translocation
2.4.1 BACTERIOSTATIC

Annotations:

  • Inh. translocation of peptidyl-tRNA from acceptor donor site
2.4.1.1 MACROLIDE (50S), CLINDAMYCIN(50S)
2.4.1.1.1 methylation of base in RNA that alter drugs binding

Annotations:

  • macrolides
3 Inhibiiton of folic acid synthesis
3.1 SULFONAMIDE

Annotations:

  • inh. duhydropteroate synthetase
3.1.1 formation of a PABA, increase resistance to inhibition of dihydropteroate synthetase
3.2 TRIMETHOPRIN & PYRIMETHAMINE

Annotations:

  • inh. dihydrofolate reductase
4 Inhibition of nucleic acid synthesis
4.1 FLUOROQUINOLONES

Annotations:

  • inh. DNA gyrase (topiosomerase 2)
4.1.1 increase transport systems to push drugs out. increase resistance to inh. of topio. 2

Annotations:

  • antibiotic resistance.  R-factor plasmid-mediated transmission. selection of resistance cells 
4.2 RIFAMPIN

Annotations:

  • inh. DNA-dep RNA polymerase

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