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E.coli

Description

Mind Map on E.coli, created by sam.hilton on 04/05/2013.

Mind Map by sam.hilton, updated more than 1 year ago

	Created by sam.hilton over 11 years ago

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Resource summary

E.coli

Pathogenic types
1. Enteropathogenic
  1. Destroys microvilli
    1. Loss of tight junctions
  2. Attaching and effacing lesions
    1. Intimin/Tir interaction
      1. TypeIII SS
      2. EspA, B and D
    2. Effect on host signalling
      1. EHEC
        Espfu>N-WASP>Arp2/3
      2. EPEC
        Nck>N-WASP>Arp2/3
2. Enterohaemorrhagic
  1. Verocytotoxin producing
  2. Shigatoxin producing
    1. Stxb
      1. Gb3 mediated entry
    2. Stxa
      1. Cleaves 28S rRNA
3. Enterotoxigenic
  1. Toxins
    1. LT
      1. ADP ribosylation Gsalpha
        CFTR phosphorylated
    2. ST
      1. STa
        Guanylate cyclase C
      2. STb
        Sulphatide
  2. Adherence
    1. CFs and TibA/Tia
4. Enteroinvasive
  1. Endocytic route
    1. Intracellular survival
5. Enteroaggregative
  1. Biofilm
    1. AAF1
  2. Toxins
    1. EAST
6. Diffusely adherent
  1. Finger projections
    1. Dr/DAF

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