E.coli

E.coli

1. Pathogenic types

   • Enteropathogenic
     • Destroys microvilli
       • Loss of tight junctions
     • Attaching and effacing lesions
       • Intimin/Tir interaction
         • TypeIII SS
         • EspA, B and D
       • Effect on host signalling
         • EHEC
           • Espfu>N-WASP>Arp2/3
         • EPEC
           • Nck>N-WASP>Arp2/3
   • Enterohaemorrhagic
     • Verocytotoxin producing
     • Shigatoxin producing
       • Stxb
         • Gb3 mediated entry
       • Stxa
         • Cleaves 28S rRNA
   • Enterotoxigenic
     • Toxins
       • LT
         • ADP ribosylation Gsalpha
           • CFTR phosphorylated
       • ST
         • STa
           • Guanylate cyclase C
         • STb
           • Sulphatide
     • Adherence
       • CFs and TibA/Tia
   • Enteroinvasive
     • Endocytic route
       • Intracellular survival
   • Enteroaggregative
     • Biofilm
       • AAF1
     • Toxins
       • EAST
   • Diffusely adherent
     • Finger projections
       • Dr/DAF