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755342
THYROID & ANTITHYROID DRUGS
Description
Mind Map on THYROID & ANTITHYROID DRUGS, created by Zulhilmi Zainal on 14/04/2014.
Mind Map by
Zulhilmi Zainal
, updated more than 1 year ago
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Created by
Zulhilmi Zainal
about 10 years ago
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Resource summary
THYROID & ANTITHYROID DRUGS
HYPOTHYROIDISM
Synthetic T3 and T4
Levothyroxine
Drug of choice
allergy rare
Liothyronine (L-T3)
More potent than levothyroxine
multiple daily doses needed
Greater cardiotoxicity
expensive
EFFECTS
increase sympathetic
Tachycardia, increase cardiac output, hypertension, arrhythmias
HYPERTHYROIDISM
ANTITHYROID AGENTS
THIOAMIDES
Methimazole & Propylthiouracil (PTU).
concentrated in the thyroid
MOA
inhibit thyroid peroxidase
Inhibit oxidation of iodide into iodine
Inhibit formation of MIT & DIT
USES
moderate hyperthyroidism
ADVERSE
Maculopapular skin rashes
fever, hepatitis, lupus-like syndrome
IODIDE SALTS (POTASSIUM IODIDE)
MOA
inhibit the release of thyroid hormones from thyroid gland
reduce size and vascularization of the hyperplastic gland
Oral
Cross placenta
withdrawal may produce severe thyrotoxicosis
USES
Initiation therapy
thyroid storm (thyrotoxicosis)
ADVERSE
sore mouth and throat
Goiter (fetus)
skin rashes (acneiform)
SODIUM IPODATE
Iodinated contrast agents (x-ray film)
MOA
rapidly inhibit the conversion of T4 to T3 in liver, kidney, pituitary gland and brain.
Use
thyroid storm
non-toxic
ANION INHIBITORS
Perchlorate (Clo4-), thiocyanate (SCN-)
MOA
block uptake of iodide by thyroid gland through competitive inhibition
Use
iodide-induced hyperthyroidism
Side Effects
toxic, aplastic anemia (rarely used).
RADIOACTIVE IODINE (RAI) 131 I
Sodium 131I orally
MOA
concentrated in thyroid, beta particle emission → destroys thyroid tissues
cross placenta, excreted in milk
contraindicated in pregnancy or lactation
USES
thyrotoxicosis
THYROTOXICOSIS IN PREGNANCY
Propylthiouracil (PTU) throughout pregnancy
THYROID STORM
life threatening syndrome
propanolol – IV → decrease severe CVS manifestations
Potassium Iodide (10 drops orally) → reduce release of thyroid hormone
PTU- reduces thyroid hormones synthesis. - inhibit peripheral deiodination of T4 toT3.
Steroid (hydrocortisone) protect patients against shock.
Treatment aims
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