Epidermal Growth Factors are 53aa long, with an Mr of 40,000
What happens when you increase ornithine carboxylase and polyamine concentrations?
Cell division increases
Cell division decreases
In general effects ( inc glucose/aa transport and inc Na/K ATPase activity) what hormone are growth factors most like?
Increase Na+/H+ pump activity causes what?
Alkylysation of the cytoplasm
Inc. DNA synthesis/mitosis
Inc protein production
How is tyrosine kinase kept inactive when a ligand is not bound?
The activation lip hides the active site
The active site is phosphorylated and inactive
A pseudosubstrate is bound
What form does inactive tyrosine kinase stay in?
What effect does ligand binding have to tyrosine kinase?
Once the activation lip is phosphorylated, what happens?
Phosphorylation continues of tyrosine kinase
Becomes fully active
Becomes partially active
Proteins bind to phosphorylated areas
Which of the following binds to phosphorylated tyrosine kinase?