Flashcards
Immunology Lec 5
Flashcards do conjunto (16)
- 1What are considered to be the best cells to activate and program NAIVE T cells?Dendritic cells
- 2What are the three main types of dendritic cells?Conventional DC's
Plasmacytoid DC's
Inflammatory DC's - 3Ultimately what is the general role of DC's?To link the innate immune system with the adaptive immune system
- 4What do CD103+ Intestinal DC's induce the generation of?Regulatory T cells
- 5Two ways that DC cells can move?Integrin dependently or integrin independently
- 6What "License's" DC's to maturePRR's
- 7What chemokine receptor do mature DC's express in particularly high levels that immature DC'S do not?CCR7
- 8What chemokine does CCR7 have good affinity for?CCL21
- 9What is the role of CCL21 in relation to DC's?CCL21 is a chemokine which promotes the movement of DC's to the lymph nodes, where the DC's can activate T cells
- 10How do the levels of costimulatory molecules such as CD80 and CD86 differ in mature DC's compared with immature DC's?There is high levels of costimulatory molecules in mature DC's, whereas there are relatively low levels in immature DC's
- 11Inflammatory dendritic cells are derived from the differentiation of what?Monocytes
- 12Harnessing the NAIVE T cell-activating properties of DC's has potential in what areas?Targeting tumours
Vaccine development - 13What causes increased expression of CCR7 in DC's?TLR signalling following recognition of a pathogen
- 14What immune cell is considered to be the best at performing phagocytosis?Macrophages
- 15Which cells specialise in taking up, processing and presenting antigen from intracellular pathogens and soluble antigens?B cells and macrophages
- 16What cells are the only one's that are really able to prime Naive T cells?Dendritic cells
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- FlashCards sobre Immunology Lec 5, criado por Chris Hughes em 23-03-2015.
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- Chris Hughes
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