Flashcards
Haemoglobin
Flashcards do conjunto (14)
- 1Describe the structure of haemoglobinHaemoglobin is made up of 4 polypeptide chains, each with a haem group which contains iron
- 2How many oxygen molecules can each haemoglobin carry?Each haemoglobin can carry 4 oxygen molecules
Association
Hb + 4O₂ ⇌ HbO₈
Dissociation - 3What is oxygen affinity?The tendency a molecule has to bind with O₂
- 4What affects oxygen affinity?Partial pressure of oxygen (pO₂)
The greater the concentration of dissolved O₂ in cells, the higher the pO₂. As pO₂ increases, affinity increases. - 5TRUE OR FALSE: Alveoli have a high pO₂TRUE
Alveoli have a high pO₂ so O₂ associates with haemoglobin - 6TRUE OR FALSE: Cells that respire have a high pO₂FALSE
Cells that respire have a LOW pO₂ - 7What is the oxyhaemoglobin dissociation curve?The oxyhaemoglobin dissociation curve is a curve that plots the proportion of haemoglobin in its saturated form on the vertical axis against the partial pressure of oxygen on the horizontal axis
- 8Complete the sentences: When haemoglobin combines with the first O₂, the shape alters, making it _________ for other O₂ to join too. HOWEVER! As haemoglobin starts to become saturated, it gets ____________ for O₂ to join.When haemoglobin combines with the first O₂, the shape alters, making it EASIER for other O₂ to join too. HOWEVER! As haemoglobin starts to become saturated, it gets HARDER for O₂ to join.
- 9How does the dissociation curve of foetal haemoglobin compare to that of adult haemoglobin?By the time the mother's blood reaches the placenta, its oxygen saturation has decreased as some have been used up by the mother's body. The placenta has a low pO₂ so adult haemoglobin will dissociate. For the foetus to get enough oxygen, it must have a higher affinity, so that it can take up O₂ in lower pO₂ than adult haemoglobin.
- 10What does the oxyhaemoglobin dissociation curve look like for foetal haemoglobin and adult haemoglobin?
- 11How does carbon dioxide affect dissociation?Haemoglobin gives O₂ more readily at a higher pCO₂. When cells respire, they raise O₂, increasing the rate of dissociation.
More O₂ is being released - 12What is the Bohr effect?A physiological phenomenon stating that haemoglobin's oxygen binding affinity is inversely related both to acidity and to the concentration of carbon dioxide
- 13Outline the process in which CO₂ binds to a red blood cell
- 14What happens when the blood reaches the lungs?When the blood reaches the lungs, the low pCO₂ causes some of the HCO₃⁻ ions and H⁺ ions to recombine into CO₂ and H₂O. The CO₂ is then diffused into the alveoli and breathed out
Informações
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- O usuário eliminou as informações de disciplina FlashCards sobre Haemoglobin, criado por Usuário eliminado em 05-03-2018.
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- Criado por Yinka F · 1 fev 2018
- Copiado por Yinka F · 5 mar 2018
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