Flashcards
Cell Signalling III
Flashcards do conjunto (15)
- 1Types of receptors (IGE IRNI)Ion channel-linked (ms)
G protein coupled (s-hours)
Enzyme-linked (s-hours)
Intrinsic Enzyme activity
Recruit enzymes from cytoplasm
Nuclear
Ionotropic
^ hours - 2TransportersUniporter - substance 1 direction
Symporter - 2 Δ sub. 1 direction
Antiporter - 2 Δ sub. Δ directions - 3Ion channel-linked RAct as gates
L-binding induces conf Δ, opening the gate - 4Pharma modding of ICLChannel blockers (physical block)
Channel modulators (bind channel, enhance/inhibit opening.) - 5GPCRsMost common
Trimeric G protein + coupled effector molecule
7 transmem helices - 6G protein binding site3rd cytoplasmic loop
Cytoplasmic C-terminal tail, sites available for +Pi - 7G proteinsGuanine nucleotide binders
- 8Forms of G proteinsMonomeric i.e. Ras
Trimeric (alpha,beta,gamma) - 9TrimericOnly alpha SU can bind Guanine
Linked to PCM by lipid chain - 10GPCR binding (4)1. Binding of L induces conf. Δ in R
2. + R binds to Gα SU
3. Binding induces conf. Δ in Gα
4. Bound GDP dissociates + is replaced by GTP.
5. Gα dissociates from Gβ/Gγ
6. L dissociated from R, Gα binds and + Effector.
7. Hydrolysis of GTP->GDP causes Gα to dissociate from Eff, re-associate with Gβ/Gγ.
SWAPS GTP FOR GDP, DOESN'T CONVERT. - 11GPCR signal termination by R desensitisationArrestin binds to +Pi form of GPCR
Competes w/ G proteins for binding
Promotes R interalisation via Clathrin-mediated endocytosis - 12Table of trimeric proteins
- 13Learn glycogen metabolism like day beforeyah
- 14cAMP level regulation using inhibitory hormoneAn example of GPCR signalling
PGE1/Adenosine inhibits adenylyl cyclase
GalphaI binds to adenylyl cyclase and inhibits it - 15Maybe learn AcCh hereendothelial cells in BV to bring about smooth muscle relaxation
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- O usuário eliminou as informações de disciplina FlashCards sobre Cell Signalling III, criado por Usuário eliminado em 31-03-2018.
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- Criado por J yadonknow · 31 mar 2018
- Copiado por J yadonknow · 31 mar 2018
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