Flashcards
HPA - Metoclopramide
Flashcards do conjunto (12)
- 1Trade namesMaxalon, Metamide, Metoclopramide Injection, Pramin
- 2Pharmaceutical calssDopamine antagonist
- 3IndicationsN + V assoc with chemo, surgery, labour etc
Treatment of GORD
Increases gastric emptying - 4ActionStimulates motility of upper GI tract and increases lower oesophageal sphincter tone and blocks dopamine receptors at chemoreceptor trigger zone.
Decreases reflux into the oesophagus by increasing the resting pressure of the lower esophageal sphincter and improves acid clearance from the esophagus by increasing amplitude of esophageal peristaltic contractions
Accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum - 5Absorption & distributionABSORPTION:GIT
DISTRIBUTION: Distributed to most body tissues and fluids, including the brain. Drug crosses the placental barrier and is distributed in breast milk. - 6Metabolism & excretionMETABOLISM + EXCRETION: Not metabolized extensively; a small amount is metabolized in the liver via conjugation. Excreted in urine and faeces.
- 7half-life5 - 6 hrs
- 8Contraindications/precautionsContraindicated in individuals hypersensitive to drug, in those where GI motility poses risks (eg. those with haemorrhage, obstruction or perforation)
Parkinson’s disease—avoid if possible as symptoms may worsen due to being a dopamine antagonist.
Depression—avoid long-term use as mental state may worsen
Contraindicated in those with phaeochromocytoma or seizure disorders - 9Adverse reactionsCNS: restlessness, drowsiness, dizziness, headache, fatigue, fever
CV: transient hypertension, hypotension
GI: nausea, diarrhoea, bowel disroders
GU: urinary frequency, incontinence
Skin: rash, urticaria - 10InteractionsAnticholinergics, opioid analgesics -antagonised GI motility effects of metoclopramide. Use cautiously together
CNS depressants - avoid use together due to additive CNS effects
Digoxin - dec. absorbtion of digoxin from stomach. Monitor.
Paracetamol, levodopa, tetracyline - accelerated absorption of drugs from small bowel. Monitor. - 11AssessmentsBlood pressure
Alertness
- nausea - 12EducationAdvise person to avoid activities requiring alertness or 2 hours after each dose.
Instruct person to report serious adverse reactions
Use short term only (maximum of 5 days); risk of tardive dyskinesia increases with cumulative dose and length of treatment
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- Criado por Em J · 10 jun 2018
- Copiado por Em J · 10 jun 2018
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